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Foxp3 forkhead box P3 [ Mus musculus (house mouse) ]

Gene ID: 20371, updated on 27-Feb-2024

Summary

Official Symbol
Foxp3provided by MGI
Official Full Name
forkhead box P3provided by MGI
Primary source
MGI:MGI:1891436
See related
Ensembl:ENSMUSG00000039521 AllianceGenome:MGI:1891436
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
sf; JM2; scurfin
Summary
The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene result in the scurfy phenotype (sf). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in spleen adult (RPKM 3.0), thymus adult (RPKM 2.4) and 28 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See Foxp3 in Genome Data Viewer
Location:
X A1.1; X 3.41 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (7445915..7461482)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (7579676..7595243)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 23082 Neighboring gene protein phosphatase 1, regulatory subunit 3F Neighboring gene STARR-positive B cell enhancer mm9_chrX:7151387-7151688 Neighboring gene Foxp3 regulating long intergenic noncoding RNA Neighboring gene coiled-coil domain containing 22 Neighboring gene calcium channel, voltage-dependent, alpha 1F subunit Neighboring gene STARR-positive B cell enhancer ABC_E1215 Neighboring gene synaptophysin Neighboring gene predicted gene 14703

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables NFAT protein binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone acetyltransferase binding ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within B cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of CD4-positive, alpha-beta T cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of CD4-positive, alpha-beta T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in T cell activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of T cell anergy IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within T cell mediated immunity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of T cell tolerance induction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of alpha-beta T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chromatin remodeling IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cytokine production IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of immature T cell proliferation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of interleukin-10 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of interleukin-2 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of interleukin-4 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of interleukin-4 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of interleukin-5 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of interleukin-5 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of isotype switching to IgE isotypes IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of lymphocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within myeloid cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of CD4-positive, alpha-beta T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of CREB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T cell cytokine production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T-helper 17 cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of alpha-beta T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of chronic inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of chronic inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of defense response to virus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of interleukin-10 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-17 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-17 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of interleukin-2 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of interleukin-2 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of interleukin-2 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of interleukin-4 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of interleukin-4 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-4 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of interleukin-5 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of interleukin-5 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of isotype switching to IgE isotypes IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of lymphocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of type II interferon production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of type II interferon production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of type II interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of type II interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within positive regulation of CD4-positive, alpha-beta T cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of T cell anergy IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of T cell tolerance induction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of immature T cell proliferation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of interleukin-4 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of peripheral T cell tolerance induction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of regulatory T cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of regulatory T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of regulatory T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transforming growth factor beta1 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of T cell anergy IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of immunoglobulin production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of isotype switching to IgG isotypes IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of regulatory T cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulatory T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within tolerance induction IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within tolerance induction to self antigen IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of transforming growth factor beta1 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of type II interferon production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of type II interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
forkhead box protein P3
Names
scurfy

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199347.1NP_001186276.1  forkhead box protein P3

    See identical proteins and their annotated locations for NP_001186276.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AF277992, AL672231, AL731793
    Consensus CDS
    CCDS29965.1
    UniProtKB/Swiss-Prot
    Q99JB6
    UniProtKB/TrEMBL
    Q53Z59, V5LWQ0
    Related
    ENSMUSP00000111405.2, ENSMUST00000115740.9
    Conserved Domains (2) summary
    pfam00250
    Location:337410
    Forkhead; Forkhead domain
    pfam16159
    Location:192259
    FOXP-CC; FOXP coiled-coil domain
  2. NM_001199348.1NP_001186277.1  forkhead box protein P3

    See identical proteins and their annotated locations for NP_001186277.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AF277991, AL672231
    Consensus CDS
    CCDS29965.1
    UniProtKB/Swiss-Prot
    Q99JB6
    UniProtKB/TrEMBL
    Q53Z59, V5LWQ0
    Related
    ENSMUSP00000111403.2, ENSMUST00000115738.8
    Conserved Domains (2) summary
    pfam00250
    Location:337410
    Forkhead; Forkhead domain
    pfam16159
    Location:192259
    FOXP-CC; FOXP coiled-coil domain
  3. NM_054039.2NP_473380.1  forkhead box protein P3

    See identical proteins and their annotated locations for NP_473380.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AF277992, AL672231, AL731793
    Consensus CDS
    CCDS29965.1
    UniProtKB/Swiss-Prot
    Q99JB6
    UniProtKB/TrEMBL
    Q53Z59, V5LWQ0
    Related
    ENSMUSP00000111404.2, ENSMUST00000115739.9
    Conserved Domains (2) summary
    pfam00250
    Location:337410
    Forkhead; Forkhead domain
    pfam16159
    Location:192259
    FOXP-CC; FOXP coiled-coil domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    7445915..7461482
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)