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EPB41L2 erythrocyte membrane protein band 4.1 like 2 [ Homo sapiens (human) ]

Gene ID: 2037, updated on 17-Jun-2019

Summary

Official Symbol
EPB41L2provided by HGNC
Official Full Name
erythrocyte membrane protein band 4.1 like 2provided by HGNC
Primary source
HGNC:HGNC:3379
See related
Ensembl:ENSG00000079819 MIM:603237
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
4.1G; 4.1-G
Expression
Ubiquitous expression in fat (RPKM 33.9), ovary (RPKM 23.5) and 23 other tissues See more
Orthologs

Genomic context

See EPB41L2 in Genome Data Viewer
Location:
6q23.1-q23.2
Exon count:
31
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (130827955..131063322, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (131160487..131384462, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378002 Neighboring gene uncharacterized LOC105378003 Neighboring gene small leucine rich protein 1 Neighboring gene uncharacterized LOC105378004 Neighboring gene uncharacterized LOC102723445 Neighboring gene A-kinase anchoring protein 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial.
NHGRI GWA Catalog
Genome-wide association identifies genetic variants associated with lentiform nucleus volume in N = 1345 young and elderly subjects.
NHGRI GWA Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
NHGRI GWA Catalog
No evidence of gene-calcium interactions from genome-wide analysis of colorectal cancer risk.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Cellular biotinylated erythrocyte membrane protein band 4.1-like 2 (EPB41L2) protein is incorporated into HIV-1 Gag virus-like particles PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Interactions of neurexins and neuroligins at synapses, organism-specific biosystem (from REACTOME)
    Interactions of neurexins and neuroligins at synapses, organism-specific biosystemNeurexins (NRXNs) and neuroligins (NLGNs) are best characterized synaptic cell-adhesion molecules. They are part of excitatory glutamatergic and inhibitory GABAergic synapses in mammalian brain, medi...
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Protein-protein interactions at synapses, organism-specific biosystem (from REACTOME)
    Protein-protein interactions at synapses, organism-specific biosystemSynapses constitute highly specialized sites of asymmetric cell-cell adhesion and intercellular communication. Its formation involves the recruitment of presynaptic and postsynaptic molecules at newl...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp781D1972, DKFZp781H1755

Gene Ontology Provided by GOA

Function Evidence Code Pubs
PH domain binding IEA
Inferred from Electronic Annotation
more info
 
actin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
spectrin binding IEA
Inferred from Electronic Annotation
more info
 
structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cortical actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein localization to cell cortex IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with COP9 signalosome IDA
Inferred from Direct Assay
more info
PubMed 
cell cortex region IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
focal adhesion HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
spectrin TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
band 4.1-like protein 2
Names
erythrocyte membrane protein band 4.1 like-protein 2
generally expressed protein 4.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135554.1NP_001129026.1  band 4.1-like protein 2 isoform b

    See identical proteins and their annotated locations for NP_001129026.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks multiple consecutive in-frame exons in the CDS, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a. Variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AB209522, BC034718, DA108957
    Consensus CDS
    CCDS47474.1
    UniProtKB/Swiss-Prot
    O43491
    UniProtKB/TrEMBL
    I6L9B1, Q59FD8
    Related
    ENSP00000376222.3, ENST00000392427.7
    Conserved Domains (6) summary
    smart00295
    Location:220409
    B41; Band 4.1 homologues
    cd13184
    Location:404497
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:302409
    FERM_M; FERM central domain
    pfam05902
    Location:611666
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:507549
    FA; FERM adjacent (FA)
    pfam09379
    Location:222285
    FERM_N; FERM N-terminal domain
  2. NM_001135555.3NP_001129027.1  band 4.1-like protein 2 isoform b

    See identical proteins and their annotated locations for NP_001129027.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR and lacks five consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. Variants 2 and 3 encode the same isoform (b), which is shorter than isoform a.
    Source sequence(s)
    AK295124, BC034718, DA108957
    Consensus CDS
    CCDS47474.1
    UniProtKB/Swiss-Prot
    O43491
    UniProtKB/TrEMBL
    I6L9B1
    Related
    ENSP00000432803.1, ENST00000525271.5
    Conserved Domains (6) summary
    smart00295
    Location:220409
    B41; Band 4.1 homologues
    cd13184
    Location:404497
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:302409
    FERM_M; FERM central domain
    pfam05902
    Location:611666
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:507549
    FA; FERM adjacent (FA)
    pfam09379
    Location:222285
    FERM_N; FERM N-terminal domain
  3. NM_001199388.2NP_001186317.1  band 4.1-like protein 2 isoform c

    See identical proteins and their annotated locations for NP_001186317.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, uses an alternate splice site in the coding region and lacks two consecutive coding exons, but maintains the reading frame, compared to variant 1. The encoded isoform (c) is shorter than isoform a. Variants 4 and 15-17 all encode the same isoform (c).
    Source sequence(s)
    AK295958, BC034718, DA108957
    Consensus CDS
    CCDS56450.1
    UniProtKB/TrEMBL
    B4DJ76, I6L9B1
    Related
    ENSP00000434576.1, ENST00000530481.5
    Conserved Domains (5) summary
    smart00295
    Location:220409
    B41; Band 4.1 homologues
    cd13184
    Location:404497
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam05902
    Location:740845
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:507549
    FA; FERM adjacent (FA)
    cl26511
    Location:9222
    Neuromodulin_N; Gap junction protein N-terminal region
  4. NM_001252660.1NP_001239589.1  band 4.1-like protein 2 isoform d

    See identical proteins and their annotated locations for NP_001239589.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and lacks three consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (d) is shorter than isoform a. Variants 6 and 18-20 all encode the same isoform (d).
    Source sequence(s)
    BC034718, CR749262, CR936793
    Consensus CDS
    CCDS59037.1
    UniProtKB/Swiss-Prot
    O43491
    UniProtKB/TrEMBL
    I6L9B1
    Related
    ENSP00000434308.1, ENST00000528282.5
    Conserved Domains (5) summary
    smart00295
    Location:220409
    B41; Band 4.1 homologues
    cd13184
    Location:404497
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam05902
    Location:635740
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:507549
    FA; FERM adjacent (FA)
    cl26511
    Location:9222
    Neuromodulin_N; Gap junction protein N-terminal region
  5. NM_001350299.1NP_001337228.1  band 4.1-like protein 2 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) represents the longest transcript and encodes the longest isoform (e).
    Source sequence(s)
    AL355360, AL358943
    Conserved Domains (6) summary
    smart00295
    Location:220409
    B41; Band 4.1 homologues
    cd13184
    Location:404497
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:630673
    SAB; SAB domain
    pfam05902
    Location:9451050
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:507549
    FA; FERM adjacent (FA)
    cl26511
    Location:9222
    Neuromodulin_N; Gap junction protein N-terminal region
  6. NM_001350301.1NP_001337230.1  band 4.1-like protein 2 isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) encodes isoform f.
    Source sequence(s)
    AL355360, AL357496, AL358943
    Conserved Domains (6) summary
    smart00295
    Location:220409
    B41; Band 4.1 homologues
    cd13184
    Location:404497
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:630673
    SAB; SAB domain
    pfam05902
    Location:9451017
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:507549
    FA; FERM adjacent (FA)
    cl26511
    Location:9222
    Neuromodulin_N; Gap junction protein N-terminal region
  7. NM_001350302.1NP_001337231.1  band 4.1-like protein 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variant 1, encodes isoform a.
    Source sequence(s)
    AL355360, AL358943
    Consensus CDS
    CCDS5141.1
    Conserved Domains (6) summary
    smart00295
    Location:220409
    B41; Band 4.1 homologues
    cd13184
    Location:404497
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:630673
    SAB; SAB domain
    pfam05902
    Location:893998
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:507549
    FA; FERM adjacent (FA)
    cl26511
    Location:9222
    Neuromodulin_N; Gap junction protein N-terminal region
  8. NM_001350303.1NP_001337232.1  band 4.1-like protein 2 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) encodes isoform g.
    Source sequence(s)
    AL355360, AL357496, AL358943
    Conserved Domains (5) summary
    smart00295
    Location:220409
    B41; Band 4.1 homologues
    cd13184
    Location:404497
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam05902
    Location:844949
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:507549
    FA; FERM adjacent (FA)
    cl26511
    Location:9222
    Neuromodulin_N; Gap junction protein N-terminal region
  9. NM_001350304.1NP_001337233.1  band 4.1-like protein 2 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variants 12 and 13, encodes isoform h.
    Source sequence(s)
    AL355360, AL357496, AL358943
    Consensus CDS
    CCDS87440.1
    Related
    ENSP00000486691.1, ENST00000628542.2
    Conserved Domains (5) summary
    smart00295
    Location:220409
    B41; Band 4.1 homologues
    cd13184
    Location:404497
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam05902
    Location:823928
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:507549
    FA; FERM adjacent (FA)
    cl26511
    Location:9222
    Neuromodulin_N; Gap junction protein N-terminal region
  10. NM_001350305.1NP_001337234.1  band 4.1-like protein 2 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12), as well as variants 11 and 13, encodes isoform h.
    Source sequence(s)
    AL355360, AL357496, AL358943
    Consensus CDS
    CCDS87440.1
    Related
    ENSP00000436348.1, ENST00000527411.5
    Conserved Domains (5) summary
    smart00295
    Location:220409
    B41; Band 4.1 homologues
    cd13184
    Location:404497
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam05902
    Location:823928
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:507549
    FA; FERM adjacent (FA)
    cl26511
    Location:9222
    Neuromodulin_N; Gap junction protein N-terminal region
  11. NM_001350306.1NP_001337235.1  band 4.1-like protein 2 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13), as well as variants 11 and 12, encodes isoform h.
    Source sequence(s)
    AL355360, AL358943
    Consensus CDS
    CCDS87440.1
    Related
    ENSP00000436641.1, ENST00000529208.5
    Conserved Domains (5) summary
    smart00295
    Location:220409
    B41; Band 4.1 homologues
    cd13184
    Location:404497
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam05902
    Location:823928
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:507549
    FA; FERM adjacent (FA)
    cl26511
    Location:9222
    Neuromodulin_N; Gap junction protein N-terminal region
  12. NM_001350307.1NP_001337236.1  band 4.1-like protein 2 isoform i

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14) encodes isoform i.
    Source sequence(s)
    AL355360, AL357496, AL358943
    Conserved Domains (5) summary
    smart00295
    Location:220409
    B41; Band 4.1 homologues
    cd13184
    Location:404497
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam05902
    Location:758863
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:507549
    FA; FERM adjacent (FA)
    cl26511
    Location:9222
    Neuromodulin_N; Gap junction protein N-terminal region
  13. NM_001350308.1NP_001337237.1  band 4.1-like protein 2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15), as well as variants 4, 16, and 17, encodes isoform c.
    Source sequence(s)
    AL355360, AL357496, AL358943
    Consensus CDS
    CCDS56450.1
    Conserved Domains (5) summary
    smart00295
    Location:220409
    B41; Band 4.1 homologues
    cd13184
    Location:404497
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam05902
    Location:740845
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:507549
    FA; FERM adjacent (FA)
    cl26511
    Location:9222
    Neuromodulin_N; Gap junction protein N-terminal region
  14. NM_001350309.1NP_001337238.1  band 4.1-like protein 2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16), as well as variants 4, 15, and 17, encodes isoform c.
    Source sequence(s)
    AL355360, AL357496, AL358943
    Consensus CDS
    CCDS56450.1
    Related
    ENSP00000431647.1, ENST00000527659.5
    Conserved Domains (5) summary
    smart00295
    Location:220409
    B41; Band 4.1 homologues
    cd13184
    Location:404497
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam05902
    Location:740845
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:507549
    FA; FERM adjacent (FA)
    cl26511
    Location:9222
    Neuromodulin_N; Gap junction protein N-terminal region
  15. NM_001350310.1NP_001337239.1  band 4.1-like protein 2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17), as well as variants 4, 15, and 16, encodes isoform c.
    Source sequence(s)
    AL355360, AL358943
    Consensus CDS
    CCDS56450.1
    Conserved Domains (5) summary
    smart00295
    Location:220409
    B41; Band 4.1 homologues
    cd13184
    Location:404497
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam05902
    Location:740845
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:507549
    FA; FERM adjacent (FA)
    cl26511
    Location:9222
    Neuromodulin_N; Gap junction protein N-terminal region
  16. NM_001350311.1NP_001337240.1  band 4.1-like protein 2 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18), as well as variants 6, 19, and 20, encodes isoform d.
    Source sequence(s)
    AL355360, AL357496, AL358943
    Consensus CDS
    CCDS59037.1
    Conserved Domains (5) summary
    smart00295
    Location:220409
    B41; Band 4.1 homologues
    cd13184
    Location:404497
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam05902
    Location:635740
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:507549
    FA; FERM adjacent (FA)
    cl26511
    Location:9222
    Neuromodulin_N; Gap junction protein N-terminal region
  17. NM_001350312.1NP_001337241.1  band 4.1-like protein 2 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19), as well as variants 6, 18, and 20, encodes isoform d.
    Source sequence(s)
    AL355360, AL357496, AL358943
    Consensus CDS
    CCDS59037.1
    Related
    ENSP00000402041.2, ENST00000445890.6
    Conserved Domains (5) summary
    smart00295
    Location:220409
    B41; Band 4.1 homologues
    cd13184
    Location:404497
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam05902
    Location:635740
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:507549
    FA; FERM adjacent (FA)
    cl26511
    Location:9222
    Neuromodulin_N; Gap junction protein N-terminal region
  18. NM_001350313.1NP_001337242.1  band 4.1-like protein 2 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (20), as well as variants 6, 18, and 19, encodes isoform d.
    Source sequence(s)
    AL355360, AL358943
    Consensus CDS
    CCDS59037.1
    Conserved Domains (5) summary
    smart00295
    Location:220409
    B41; Band 4.1 homologues
    cd13184
    Location:404497
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam05902
    Location:635740
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:507549
    FA; FERM adjacent (FA)
    cl26511
    Location:9222
    Neuromodulin_N; Gap junction protein N-terminal region
  19. NM_001350314.1NP_001337243.1  band 4.1-like protein 2 isoform j

    Status: VALIDATED

    Description
    Transcript Variant: This variant (21), as well as variant 22, encodes isoform j.
    Source sequence(s)
    AL355360, AL357496, AL358943
    Consensus CDS
    CCDS87439.1
    Related
    ENSP00000431988.1, ENST00000525193.5
    Conserved Domains (5) summary
    smart00295
    Location:220409
    B41; Band 4.1 homologues
    cd13184
    Location:404497
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam05902
    Location:611699
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:507549
    FA; FERM adjacent (FA)
    cl26511
    Location:9222
    Neuromodulin_N; Gap junction protein N-terminal region
  20. NM_001350315.1NP_001337244.1  band 4.1-like protein 2 isoform j

    Status: VALIDATED

    Description
    Transcript Variant: This variant (22), as well as variant 21, encodes isoform j.
    Source sequence(s)
    AL355360, AL357496, AL358943
    Consensus CDS
    CCDS87439.1
    Conserved Domains (5) summary
    smart00295
    Location:220409
    B41; Band 4.1 homologues
    cd13184
    Location:404497
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam05902
    Location:611699
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:507549
    FA; FERM adjacent (FA)
    cl26511
    Location:9222
    Neuromodulin_N; Gap junction protein N-terminal region
  21. NM_001350320.1NP_001337249.1  band 4.1-like protein 2 isoform k

    Status: VALIDATED

    Description
    Transcript Variant: This variant (23) encodes isoform k.
    Source sequence(s)
    AL355360, AL357496, AL358943
    Conserved Domains (3) summary
    cd13184
    Location:295
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam05902
    Location:421526
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:105147
    FA; FERM adjacent (FA)
  22. NM_001431.4NP_001422.1  band 4.1-like protein 2 isoform a

    See identical proteins and their annotated locations for NP_001422.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1), as well as variant 9, encodes isoform a.
    Source sequence(s)
    AF027299, BC034718, DA108957
    Consensus CDS
    CCDS5141.1
    UniProtKB/Swiss-Prot
    O43491
    UniProtKB/TrEMBL
    I6L9B1
    Related
    ENSP00000338481.3, ENST00000337057.8
    Conserved Domains (6) summary
    smart00295
    Location:220409
    B41; Band 4.1 homologues
    cd13184
    Location:404497
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:630673
    SAB; SAB domain
    pfam05902
    Location:893998
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:507549
    FA; FERM adjacent (FA)
    cl26511
    Location:9222
    Neuromodulin_N; Gap junction protein N-terminal region

RNA

  1. NR_146620.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL355360, AL357496, AL358943

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    130827955..131063322 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010353.2XP_016865842.1  band 4.1-like protein 2 isoform X1

    Conserved Domains (6) summary
    smart00295
    Location:220409
    B41; Band 4.1 homologues
    cd13184
    Location:404497
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:630673
    SAB; SAB domain
    pfam05902
    Location:9451050
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:507549
    FA; FERM adjacent (FA)
    cl26511
    Location:9222
    Neuromodulin_N; Gap junction protein N-terminal region
  2. XM_011535528.2XP_011533830.1  band 4.1-like protein 2 isoform X5

    Conserved Domains (6) summary
    smart00295
    Location:220409
    B41; Band 4.1 homologues
    cd13184
    Location:404497
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:302409
    FERM_M; FERM central domain
    pfam05902
    Location:841946
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:507549
    FA; FERM adjacent (FA)
    pfam09379
    Location:222285
    FERM_N; FERM N-terminal domain
  3. XM_011535527.2XP_011533829.1  band 4.1-like protein 2 isoform X3

    Conserved Domains (7) summary
    smart00295
    Location:220409
    B41; Band 4.1 homologues
    cd13184
    Location:404497
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:302409
    FERM_M; FERM central domain
    pfam04382
    Location:630673
    SAB; SAB domain
    pfam05902
    Location:9111016
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:507549
    FA; FERM adjacent (FA)
    pfam09379
    Location:222285
    FERM_N; FERM N-terminal domain
  4. XM_011535525.2XP_011533827.1  band 4.1-like protein 2 isoform X2

    Conserved Domains (7) summary
    smart00295
    Location:220409
    B41; Band 4.1 homologues
    cd13184
    Location:404497
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:302409
    FERM_M; FERM central domain
    pfam04382
    Location:630673
    SAB; SAB domain
    pfam05902
    Location:9271032
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:507549
    FA; FERM adjacent (FA)
    pfam09379
    Location:222285
    FERM_N; FERM N-terminal domain
  5. XM_017010356.2XP_016865845.1  band 4.1-like protein 2 isoform X4

  6. XM_011535524.2XP_011533826.1  band 4.1-like protein 2 isoform X1

    Conserved Domains (6) summary
    smart00295
    Location:220409
    B41; Band 4.1 homologues
    cd13184
    Location:404497
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:630673
    SAB; SAB domain
    pfam05902
    Location:9451050
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:507549
    FA; FERM adjacent (FA)
    cl26511
    Location:9222
    Neuromodulin_N; Gap junction protein N-terminal region
  7. XM_017010350.2XP_016865839.1  band 4.1-like protein 2 isoform X1

    Conserved Domains (6) summary
    smart00295
    Location:220409
    B41; Band 4.1 homologues
    cd13184
    Location:404497
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:630673
    SAB; SAB domain
    pfam05902
    Location:9451050
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:507549
    FA; FERM adjacent (FA)
    cl26511
    Location:9222
    Neuromodulin_N; Gap junction protein N-terminal region
  8. XM_024446349.1XP_024302117.1  band 4.1-like protein 2 isoform X7

    Conserved Domains (6) summary
    smart00295
    Location:220409
    B41; Band 4.1 homologues
    cd13184
    Location:404497
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:630673
    SAB; SAB domain
    pfam05902
    Location:9671072
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:507549
    FA; FERM adjacent (FA)
    cl26511
    Location:9222
    Neuromodulin_N; Gap junction protein N-terminal region
  9. XM_017010352.1XP_016865841.1  band 4.1-like protein 2 isoform X1

    Conserved Domains (6) summary
    smart00295
    Location:220409
    B41; Band 4.1 homologues
    cd13184
    Location:404497
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:630673
    SAB; SAB domain
    pfam05902
    Location:9451050
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:507549
    FA; FERM adjacent (FA)
    cl26511
    Location:9222
    Neuromodulin_N; Gap junction protein N-terminal region
  10. XM_017010351.1XP_016865840.1  band 4.1-like protein 2 isoform X1

    Conserved Domains (6) summary
    smart00295
    Location:220409
    B41; Band 4.1 homologues
    cd13184
    Location:404497
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:630673
    SAB; SAB domain
    pfam05902
    Location:9451050
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:507549
    FA; FERM adjacent (FA)
    cl26511
    Location:9222
    Neuromodulin_N; Gap junction protein N-terminal region
  11. XM_017010364.1XP_016865853.1  band 4.1-like protein 2 isoform X6

RNA

  1. XR_001743213.2 RNA Sequence

  2. XR_001743217.2 RNA Sequence

  3. XR_001743216.2 RNA Sequence

  4. XR_001743215.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001199389.1: Suppressed sequence

    Description
    NM_001199389.1: This RefSeq was permanently suppressed because currently there is insufficient support for the exon combination of the transcript.
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