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Selenow selenoprotein W [ Mus musculus (house mouse) ]

Gene ID: 20364, updated on 19-Sep-2024

Summary

Official Symbol
Selenowprovided by MGI
Official Full Name
selenoprotein Wprovided by MGI
Primary source
MGI:MGI:1100878
See related
Ensembl:ENSMUSG00000041571 AllianceGenome:MGI:1100878
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
selW; Sepw1
Summary
This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is highly expressed in skeletal muscle and brain. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, and has been shown to function as a glutathione-dependent antioxidant in vivo. Studies in mouse suggest that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. [provided by RefSeq, Apr 2017]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 402.4), cortex adult (RPKM 391.8) and 28 other tissues See more
Orthologs
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Genomic context

See Selenow in Genome Data Viewer
Location:
7 8.62 cM; 7 A2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (15651133..15656296, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (15917208..15922371, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18114 Neighboring gene cone-rod homeobox, opposite strand Neighboring gene STARR-seq mESC enhancer starr_18115 Neighboring gene argininosuccinate synthetase pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E2813 Neighboring gene small nucleolar RNA, C/D box 23 Neighboring gene STARR-positive B cell enhancer ABC_E2814 Neighboring gene NOP53 ribosome biogenesis factor Neighboring gene predicted gene, 24576 Neighboring gene EH-domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General protein information

Preferred Names
selenoprotein W
Names
selenoprotein W, muscle 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009156.2NP_033182.1  selenoprotein W

    See identical proteins and their annotated locations for NP_033182.1

    Status: REVIEWED

    Source sequence(s)
    AF015284, BU604713
    Consensus CDS
    CCDS39778.1
    UniProtKB/Swiss-Prot
    O35965, P49904, P63300, Q9JIC2
    Related
    ENSMUSP00000038943.9, ENSMUST00000044355.11
    Conserved Domains (1) summary
    TIGR02174
    Location:577
    CXXU_selWTH; selT/selW/selH selenoprotein domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    15651133..15656296 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)