U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Septin8 septin 8 [ Mus musculus (house mouse) ]

Gene ID: 20362, updated on 12-May-2024

Summary

Official Symbol
Septin8provided by MGI
Official Full Name
septin 8provided by MGI
Primary source
MGI:MGI:894310
See related
Ensembl:ENSMUSG00000018398 AllianceGenome:MGI:894310
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sepl; Sept8
Summary
Predicted to enable GTPase activity; SNARE binding activity; and molecular adaptor activity. Predicted to be involved in several processes, including regulation of SNARE complex assembly; regulation of intracellular protein transport; and regulation of protein stability. Located in myelin sheath. Part of septin complex. Is expressed in dermis; spinal cord ventricular layer; turbinate bone primordium; and ventral grey horn. Orthologous to human SEPTIN8 (septin 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 43.1), cerebellum adult (RPKM 41.9) and 26 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Septin8 in Genome Data Viewer
Location:
11 B1.3; 11 31.96 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (53410224..53440432)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (53519397..53549605)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 9945 Neighboring gene predicted gene, 19835 Neighboring gene ribosomal protein L9, pseudogene 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:53330337-53330520 Neighboring gene STARR-seq mESC enhancer starr_29486 Neighboring gene RIKEN cDNA A430108G06 gene Neighboring gene cyclin-like Neighboring gene kinesin family member 3A Neighboring gene STARR-seq mESC enhancer starr_29488 Neighboring gene interleukin 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (5)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0202

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables SNARE binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cytoskeleton-dependent cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of SNARE complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of intracellular protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cell division site IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in myelin sheath HDA PubMed 
located_in myelin sheath ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
 
part_of septin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of septin complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in septin ring IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252332.2NP_001239261.1  septin-8 isoform 2

    See identical proteins and their annotated locations for NP_001239261.1

    Status: VALIDATED

    Source sequence(s)
    AL596095
    Consensus CDS
    CCDS56768.1
    UniProtKB/Swiss-Prot
    B1AQY7, Q80YC7, Q8CHH9, Q9ESF7
    Related
    ENSMUSP00000104615.2, ENSMUST00000108987.8
    Conserved Domains (1) summary
    cd01850
    Location:41309
    CDC_Septin; CDC/Septin GTPase family
  2. NM_001252333.2NP_001239262.1  septin-8 isoform 3

    See identical proteins and their annotated locations for NP_001239262.1

    Status: VALIDATED

    Source sequence(s)
    AL596095
    UniProtKB/Swiss-Prot
    Q8CHH9
    Conserved Domains (1) summary
    cd01850
    Location:41307
    CDC_Septin; CDC/Septin GTPase family
  3. NM_001347496.2NP_001334425.1  septin-8 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL596095
    Consensus CDS
    CCDS83805.1
    UniProtKB/TrEMBL
    B1AQZ0
    Related
    ENSMUSP00000113038.2, ENSMUST00000121334.8
  4. NM_001361968.2NP_001348897.1  septin-8 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL596095
    Conserved Domains (1) summary
    cd01850
    Location:41307
    CDC_Septin; CDC/Septin GTPase family
  5. NM_001361969.2NP_001348898.1  septin-8 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL596095
    Conserved Domains (1) summary
    cd01850
    Location:1247
    CDC_Septin; CDC/Septin GTPase family
  6. NM_033144.3NP_149156.1  septin-8 isoform 1

    See identical proteins and their annotated locations for NP_149156.1

    Status: VALIDATED

    Source sequence(s)
    AL596095
    Consensus CDS
    CCDS48794.1
    UniProtKB/Swiss-Prot
    Q8CHH9
    Related
    ENSMUSP00000112920.2, ENSMUST00000117061.8
    Conserved Domains (1) summary
    cd01850
    Location:41309
    CDC_Septin; CDC/Septin GTPase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    53410224..53440432
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532633.4XP_006532696.1  septin-8 isoform X1

    Conserved Domains (1) summary
    cd01850
    Location:41309
    CDC_Septin; CDC/Septin GTPase family
  2. XM_006532635.5XP_006532698.1  septin-8 isoform X3

    UniProtKB/TrEMBL
    B1AQY9
    Related
    ENSMUSP00000120427.2, ENSMUST00000147912.2
    Conserved Domains (1) summary
    cd01850
    Location:41309
    CDC_Septin; CDC/Septin GTPase family
  3. XM_017314392.3XP_017169881.1  septin-8 isoform X2

    Conserved Domains (1) summary
    cd01850
    Location:41307
    CDC_Septin; CDC/Septin GTPase family
  4. XM_030245721.2XP_030101581.1  septin-8 isoform X5

    Conserved Domains (1) summary
    cd01850
    Location:41307
    CDC_Septin; CDC/Septin GTPase family
  5. XM_011248834.4XP_011247136.1  septin-8 isoform X4

    UniProtKB/TrEMBL
    B7ZC46
    Related
    ENSMUSP00000113775.3, ENSMUST00000120878.9
    Conserved Domains (1) summary
    cd01850
    Location:41307
    CDC_Septin; CDC/Septin GTPase family
  6. XM_030245722.2XP_030101582.1  septin-8 isoform X6

    Conserved Domains (1) summary
    cd01850
    Location:1249
    CDC_Septin; CDC/Septin GTPase family