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CDY2B chromodomain Y-linked 2B [ Homo sapiens (human) ]

Gene ID: 203611, updated on 23-Nov-2021

Summary

Official Symbol
CDY2Bprovided by HGNC
Official Full Name
chromodomain Y-linked 2Bprovided by HGNC
Primary source
HGNC:HGNC:23921
See related
Ensembl:ENSG00000129873
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDY
Summary
This intronless gene encodes a protein containing a chromodomain and a histone acetyltransferase catalytic domain. Chromodomain proteins are components of heterochromatin-like complexes and can act as gene repressors. This protein is localized to the nucleus of late spermatids where histone hyperacetylation takes place. Histone hyperacetylation is thought to facilitate the transition in which protamines replace histones as the major DNA-packaging protein. Two nearly identical copies of this gene are found in a palindromic region on chromosome Y; this record represents the centromeric copy. Chromosome Y also contains a pair of closely related genes in another more telomeric palindrome as well as several related pseudogenes. [provided by RefSeq, Jul 2008]
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Genomic context

See CDY2B in Genome Data Viewer
Location:
Yq11.222
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) Y NC_000024.10 (17878260..17880220, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (19990140..19992100, complement)

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene OFD1 pseudogene 1 Y-linked Neighboring gene elongin C pseudogene 6 Neighboring gene chromodomain Y-linked 6 pseudogene Neighboring gene USP9Y pseudogene 7

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC163298, MGC163300

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in histone acetylation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatogenesis TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
testis-specific chromodomain protein Y 2
Names
Y chromosome chromodomain protein 2B
chromodomain protein, Y chromosome, 2 related
chromodomain protein, Y-linked, 2B
testis-specific chromodomain protein Y protein 2 related
NP_001001722.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_004636.1 

    Range
    362165..364124 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001001722.2NP_001001722.1  testis-specific chromodomain protein Y 2

    See identical proteins and their annotated locations for NP_001001722.1

    Status: REVIEWED

    Source sequence(s)
    AC009976, BC069087
    Consensus CDS
    CCDS35473.1
    UniProtKB/Swiss-Prot
    Q9Y6F7
    Related
    ENSP00000372319.3, ENST00000382867.4
    Conserved Domains (2) summary
    cd06558
    Location:287483
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
    smart00298
    Location:558
    CHROMO; Chromatin organization modifier domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p13 Primary Assembly

    Range
    17878260..17880220 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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