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Sema5a sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A [ Mus musculus (house mouse) ]

Gene ID: 20356, updated on 5-Jan-2022

Summary

Official Symbol
Sema5aprovided by MGI
Official Full Name
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5Aprovided by MGI
Primary source
MGI:MGI:107556
See related
Ensembl:ENSMUSG00000022231
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
semF; Semaf; AI464145; 5930434A13; 9130201M22Rik
Summary
Enables axon guidance receptor activity and semaphorin receptor binding activity. Involved in several processes, including blood vessel endothelial cell proliferation involved in sprouting angiogenesis; negative regulation of endothelial cell apoptotic process; and regulation of signal transduction. Acts upstream of or within axonogenesis; branching involved in blood vessel morphogenesis; and detection of light stimulus involved in visual perception. Is integral component of membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human SEMA5A (semaphorin 5A). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in ovary adult (RPKM 13.8), limb E14.5 (RPKM 11.9) and 21 other tissues See more
Orthologs
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Genomic context

See Sema5a in Genome Data Viewer
Location:
15 B3.1; 15 13.02 cM
Exon count:
27
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (32244959..32696487)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (32244813..32696341)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (32174568..32626096)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32499 Neighboring gene taste receptor, type 2, member 119 Neighboring gene small nucleolar RNA, C/D box 123 Neighboring gene small nucleolar RNA host gene 18 Neighboring gene predicted gene, 53870 Neighboring gene predicted gene, 41289 Neighboring gene predicted gene, 32618

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables axon guidance receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables chemorepellent activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chondroitin sulfate proteoglycan binding ISO
Inferred from Sequence Orthology
more info
 
enables heparan sulfate proteoglycan binding ISO
Inferred from Sequence Orthology
more info
 
enables semaphorin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables semaphorin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables syndecan binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in axon extension IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within axon extension IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axonal fasciculation ISO
Inferred from Sequence Orthology
more info
 
involved_in blood vessel endothelial cell proliferation involved in sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within branching involved in blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within branching morphogenesis of an epithelial tube IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within detection of light stimulus involved in visual perception IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in diencephalon development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of axon extension involved in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of axon extension involved in axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of endothelial cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in neural crest cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within neuron projection extension IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within neuron projection extension IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuron projection guidance IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of actin filament depolymerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of axon extension involved in axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of endothelial cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of extracellular matrix disassembly NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of protein kinase B signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in semaphorin-plexin signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in semaphorin-plexin signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal clustering IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal clustering ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
semaphorin-5A
Names
M-Sema D
sema F
semaphorin F

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009154.2NP_033180.2  semaphorin-5A precursor

    See identical proteins and their annotated locations for NP_033180.2

    Status: VALIDATED

    Source sequence(s)
    AC110236, AK141612, BB643469
    Consensus CDS
    CCDS37055.1
    UniProtKB/TrEMBL
    Q3UPZ0
    Related
    ENSMUSP00000069024.7, ENSMUST00000067458.7
    Conserved Domains (3) summary
    cd11263
    Location:50485
    Sema_5A; The Sema domain, a protein interacting module, of semaphorin 5A (Sema5A)
    smart00209
    Location:598651
    TSP1; Thrombospondin type 1 repeats
    pfam01437
    Location:486533
    PSI; Plexin repeat

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    32244959..32696487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159282.1XP_036015175.1  semaphorin-5A isoform X1

    Conserved Domains (3) summary
    cd11263
    Location:50485
    Sema_5A; The Sema domain, a protein interacting module, of semaphorin 5A (Sema5A)
    smart00209
    Location:598651
    TSP1; Thrombospondin type 1 repeats
    pfam01437
    Location:486533
    PSI; Plexin repeat
  2. XM_030248431.2XP_030104291.1  semaphorin-5A isoform X1

    Conserved Domains (3) summary
    cd11263
    Location:50485
    Sema_5A; The Sema domain, a protein interacting module, of semaphorin 5A (Sema5A)
    smart00209
    Location:598651
    TSP1; Thrombospondin type 1 repeats
    pfam01437
    Location:486533
    PSI; Plexin repeat
  3. XM_030248430.2XP_030104290.1  semaphorin-5A isoform X1

    Conserved Domains (3) summary
    cd11263
    Location:50485
    Sema_5A; The Sema domain, a protein interacting module, of semaphorin 5A (Sema5A)
    smart00209
    Location:598651
    TSP1; Thrombospondin type 1 repeats
    pfam01437
    Location:486533
    PSI; Plexin repeat
  4. XM_036159281.1XP_036015174.1  semaphorin-5A isoform X1

    Conserved Domains (3) summary
    cd11263
    Location:50485
    Sema_5A; The Sema domain, a protein interacting module, of semaphorin 5A (Sema5A)
    smart00209
    Location:598651
    TSP1; Thrombospondin type 1 repeats
    pfam01437
    Location:486533
    PSI; Plexin repeat
  5. XM_036159283.1XP_036015176.1  semaphorin-5A isoform X2

    Conserved Domains (3) summary
    smart00209
    Location:441494
    TSP1; Thrombospondin type 1 repeats
    pfam01437
    Location:329376
    PSI; Plexin repeat
    cl15693
    Location:1328
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
  6. XM_011245340.2XP_011243642.1  semaphorin-5A isoform X1

    See identical proteins and their annotated locations for XP_011243642.1

    UniProtKB/TrEMBL
    Q3UPZ0
    Conserved Domains (3) summary
    cd11263
    Location:50485
    Sema_5A; The Sema domain, a protein interacting module, of semaphorin 5A (Sema5A)
    smart00209
    Location:598651
    TSP1; Thrombospondin type 1 repeats
    pfam01437
    Location:486533
    PSI; Plexin repeat
  7. XM_036159280.1XP_036015173.1  semaphorin-5A isoform X1

    Conserved Domains (3) summary
    cd11263
    Location:50485
    Sema_5A; The Sema domain, a protein interacting module, of semaphorin 5A (Sema5A)
    smart00209
    Location:598651
    TSP1; Thrombospondin type 1 repeats
    pfam01437
    Location:486533
    PSI; Plexin repeat
  8. XM_006520043.5XP_006520106.1  semaphorin-5A isoform X1

    See identical proteins and their annotated locations for XP_006520106.1

    UniProtKB/TrEMBL
    Q3UPZ0
    Conserved Domains (3) summary
    cd11263
    Location:50485
    Sema_5A; The Sema domain, a protein interacting module, of semaphorin 5A (Sema5A)
    smart00209
    Location:598651
    TSP1; Thrombospondin type 1 repeats
    pfam01437
    Location:486533
    PSI; Plexin repeat
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