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ZNF449 zinc finger protein 449 [ Homo sapiens (human) ]

Gene ID: 203523, updated on 10-Dec-2019

Summary

Official Symbol
ZNF449provided by HGNC
Official Full Name
zinc finger protein 449provided by HGNC
Primary source
HGNC:HGNC:21039
See related
Ensembl:ENSG00000173275 MIM:300627
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZSCAN19
Summary
This gene encodes a nuclear protein that likely functions as a transcription factor. The protein includes an N-terminal SCAN domain, and seven C2H2-type zinc finger motifs. [provided by RefSeq, May 2010]
Expression
Ubiquitous expression in adrenal (RPKM 2.8), thyroid (RPKM 2.3) and 25 other tissues See more
Orthologs

Genomic context

See ZNF449 in Genome Data Viewer
Location:
Xq26.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (135344770..135363413)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (134478696..134497338)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 75D Neighboring gene uncharacterized LOC105373342 Neighboring gene embryonic testis differentiation homolog C Neighboring gene uncharacterized LOC100506790 Neighboring gene small integral membrane protein 10 like 2A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23614

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
spermatogonial cell division IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 449
Names
zinc finger and SCAN domain-containing protein 19

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021220.1 RefSeqGene

    Range
    5026..23643
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_152695.6NP_689908.3  zinc finger protein 449

    See identical proteins and their annotated locations for NP_689908.3

    Status: REVIEWED

    Source sequence(s)
    AY280801, BC060768, BX537604, DA319333
    Consensus CDS
    CCDS14649.1
    UniProtKB/Swiss-Prot
    Q6P9G9
    UniProtKB/TrEMBL
    Q7Z3P1
    Related
    ENSP00000339585.4, ENST00000339249.5
    Conserved Domains (5) summary
    COG5048
    Location:321483
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:235402
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:325345
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:477502
    zf-H2C2_2; Zinc-finger double domain
    cl02605
    Location:27134
    SCAN; SCAN oligomerization domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    135344770..135363413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531314.3XP_011529616.1  zinc finger protein 449 isoform X3

    Conserved Domains (5) summary
    cd11674
    Location:173226
    lambda-1; inner capsid protein lambda-1 or VP3
    COG5048
    Location:201354
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:205225
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:203225
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:301326
    zf-H2C2_2; Zinc-finger double domain
  2. XM_011531312.2XP_011529614.1  zinc finger protein 449 isoform X1

    See identical proteins and their annotated locations for XP_011529614.1

    UniProtKB/Swiss-Prot
    Q6P9G9
    Conserved Domains (5) summary
    COG5048
    Location:321483
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:235402
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:325345
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:477502
    zf-H2C2_2; Zinc-finger double domain
    cl02605
    Location:27134
    SCAN; SCAN oligomerization domain
  3. XM_017029350.1XP_016884839.1  zinc finger protein 449 isoform X2

    Conserved Domains (5) summary
    cd11674
    Location:178231
    lambda-1; inner capsid protein lambda-1 or VP3
    COG5048
    Location:206359
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:210230
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:208230
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:306331
    zf-H2C2_2; Zinc-finger double domain
  4. XM_017029351.1XP_016884840.1  zinc finger protein 449 isoform X2

    Conserved Domains (5) summary
    cd11674
    Location:178231
    lambda-1; inner capsid protein lambda-1 or VP3
    COG5048
    Location:206359
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:210230
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:208230
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:306331
    zf-H2C2_2; Zinc-finger double domain
  5. XM_011531313.3XP_011529615.1  zinc finger protein 449 isoform X2

    Conserved Domains (5) summary
    cd11674
    Location:178231
    lambda-1; inner capsid protein lambda-1 or VP3
    COG5048
    Location:206359
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:210230
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:208230
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:306331
    zf-H2C2_2; Zinc-finger double domain
  6. XM_017029352.1XP_016884841.1  zinc finger protein 449 isoform X4

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