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Sema4b sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B [ Mus musculus (house mouse) ]

Gene ID: 20352, updated on 28-Dec-2022

Summary

Official Symbol
Sema4bprovided by MGI
Official Full Name
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Bprovided by MGI
Primary source
MGI:MGI:107559
See related
Ensembl:ENSMUSG00000030539 AllianceGenome:MGI:107559
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SemC; Semac; sema C; mKIAA1745
Summary
Predicted to enable chemorepellent activity and semaphorin receptor binding activity. Predicted to be involved in several processes, including generation of neurons; neural crest cell migration; and semaphorin-plexin signaling pathway. Predicted to act upstream of or within cell differentiation and nervous system development. Located in plasma membrane and synapse. Is expressed in several structures, including back musculature; central nervous system; peripheral nervous system ganglion; and retina. Orthologous to human SEMA4B (semaphorin 4B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 31.2), duodenum adult (RPKM 28.9) and 27 other tissues See more
Orthologs
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Genomic context

See Sema4b in Genome Data Viewer
Location:
7; 7 D2
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (79836618..79876394)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (80186870..80226646)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene isocitrate dehydrogenase 2 (NADP+), mitochondrial Neighboring gene predicted gene, 53380 Neighboring gene predicted gene 45202 Neighboring gene calcium and integrin binding 1 (calmyrin) Neighboring gene GDP-D-glucose phosphorylase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (4) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1745

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chemorepellent activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables semaphorin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of axon extension involved in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in neural crest cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in semaphorin-plexin signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse IPI
Inferred from Physical Interaction
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in postsynaptic density membrane IPI
Inferred from Physical Interaction
more info
PubMed 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
semaphorin-4B
Names
semaphorin-C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360135.2NP_001347064.1  semaphorin-4B precursor

    Status: VALIDATED

    Source sequence(s)
    AC109232
    Consensus CDS
    CCDS21391.1
    UniProtKB/Swiss-Prot
    Q69ZB7
    Related
    ENSMUSP00000145622.2, ENSMUST00000205822.2
    Conserved Domains (3) summary
    pfam01437
    Location:512558
    PSI; Plexin repeat
    cd05872
    Location:579663
    Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
    cl15693
    Location:48511
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
  2. NM_013659.5NP_038687.2  semaphorin-4B precursor

    See identical proteins and their annotated locations for NP_038687.2

    Status: VALIDATED

    Source sequence(s)
    AC109232
    Consensus CDS
    CCDS21391.1
    UniProtKB/Swiss-Prot
    Q62179, Q69ZB7
    Related
    ENSMUSP00000032754.8, ENSMUST00000032754.9
    Conserved Domains (3) summary
    pfam01437
    Location:512558
    PSI; Plexin repeat
    cd05872
    Location:579663
    Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
    cl15693
    Location:48511
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    79836618..79876394
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152820.1XP_036008713.1  semaphorin-4B isoform X1

    UniProtKB/Swiss-Prot
    Q69ZB7
    Conserved Domains (3) summary
    pfam01437
    Location:512558
    PSI; Plexin repeat
    cd05872
    Location:579663
    Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
    cl15693
    Location:48511
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
  2. XM_030242259.2XP_030098119.2  semaphorin-4B isoform X1

    UniProtKB/Swiss-Prot
    Q69ZB7
    Conserved Domains (3) summary
    pfam01437
    Location:512558
    PSI; Plexin repeat
    cd05872
    Location:579663
    Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
    cl15693
    Location:48511
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins