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Sema3e sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E [ Mus musculus (house mouse) ]

Gene ID: 20349, updated on 9-Jun-2019

Summary

Official Symbol
Sema3eprovided by MGI
Official Full Name
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Eprovided by MGI
Primary source
MGI:MGI:1340034
See related
Ensembl:ENSMUSG00000063531
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Semah; AA408817; mKIAA0331; 6430702L12
Expression
Biased expression in lung adult (RPKM 7.6), placenta adult (RPKM 3.8) and 10 other tissues See more
Orthologs

Genomic context

See Sema3e in Genome Data Viewer
Location:
5; 5 A1
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (14025276..14256689)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (14025276..14256689)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 35702 Neighboring gene DND microRNA-mediated repression inhibitor 1, pseudogene Neighboring gene piccolo (presynaptic cytomatrix protein) Neighboring gene arginine/serine-rich coiled-coil 2 pseudogene Neighboring gene predicted gene 9758

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
chemorepellent activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuropilin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
semaphorin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
semaphorin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
branching involved in blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of axon extension involved in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
neural crest cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of actin cytoskeleton reorganization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
semaphorin-plexin signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
semaphorin-plexin signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
synapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
extracellular space HDA PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
semaphorin-3E
Names
sema H
semaphorin-H

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011348.2NP_035478.2  semaphorin-3E precursor

    See identical proteins and their annotated locations for NP_035478.2

    Status: VALIDATED

    Source sequence(s)
    AC120420, AF034744, AK141295, AK142340, BE947109
    Consensus CDS
    CCDS19093.1
    UniProtKB/Swiss-Prot
    P70275
    Related
    ENSMUSP00000073612.6, ENSMUST00000073957.7
    Conserved Domains (3) summary
    cd05871
    Location:585675
    Ig_Semaphorin_classIII; Immunoglobulin (Ig)-like domain of class III semaphorin
    cd11253
    Location:49519
    Sema_3E; The Sema domain, a protein interacting module, of semaphorin 3E (Sema3E)
    smart00423
    Location:518566
    PSI; domain found in Plexins, Semaphorins and Integrins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

    Range
    14025276..14256689
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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