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NRK Nik related kinase [ Homo sapiens (human) ]

Gene ID: 203447, updated on 24-Nov-2020

Summary

Official Symbol
NRKprovided by HGNC
Official Full Name
Nik related kinaseprovided by HGNC
Primary source
HGNC:HGNC:25391
See related
Ensembl:ENSG00000123572 MIM:300791
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NESK
Summary
The mouse ortholog of this gene encodes a protein kinase required for JNK activation. The encoded protein may be involved in the induction of actin polymerization in late embryogenesis.[provided by RefSeq, Jun 2010]
Expression
Biased expression in ovary (RPKM 15.5), placenta (RPKM 15.0) and 8 other tissues See more
Orthologs

Genomic context

See NRK in Genome Data Viewer
Location:
Xq22.3
Exon count:
30
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (105821942..105958610)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (105066536..105202602)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene interleukin 1 receptor accessory protein like 2 Neighboring gene uncharacterized LOC107985680 Neighboring gene uncharacterized LOC105373303 Neighboring gene RNA, U6 small nuclear 207, pseudogene Neighboring gene uncharacterized LOC105373304 Neighboring gene HNF1 motif-containing MPRA enhancer 3 Neighboring gene uncharacterized LOC105373305 Neighboring gene serpin family A member 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16788, MGC131849, DKFZp686A17109

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin cytoskeleton reorganization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of JNKK activity IEA
Inferred from Electronic Annotation
more info
 
activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
parturition IEA
Inferred from Electronic Annotation
more info
 
regulation of spongiotrophoblast cell proliferation IEA
Inferred from Electronic Annotation
more info
 
signal transduction by protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
stress-activated protein kinase signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
nik-related protein kinase
NP_940867.2
XP_006724695.1
XP_006724696.1
XP_006724697.1
XP_011529189.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021425.2 RefSeqGene

    Range
    4997..141068
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_198465.4NP_940867.2  nik-related protein kinase

    See identical proteins and their annotated locations for NP_940867.2

    Status: REVIEWED

    Source sequence(s)
    BX538345, KF459287, Z68339, Z69734, Z70274, Z83850
    Consensus CDS
    CCDS65305.1
    UniProtKB/Swiss-Prot
    Q7Z2Y5
    Related
    ENSP00000434830.1, ENST00000243300.14
    Conserved Domains (3) summary
    smart00220
    Location:25313
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02434
    Location:12131549
    CNH; CNH domain
    cl21453
    Location:18313
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    105821942..105958610
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530887.3XP_011529189.1  nik-related protein kinase isoform X3

    Conserved Domains (3) summary
    smart00220
    Location:29258
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02434
    Location:11581494
    CNH; CNH domain
    cl21453
    Location:29258
    PKc_like; Protein Kinases, catalytic domain
  2. XM_006724632.3XP_006724695.1  nik-related protein kinase isoform X1

    Conserved Domains (3) summary
    smart00220
    Location:25313
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02434
    Location:12131541
    CNH; CNH domain
    cl21453
    Location:18313
    PKc_like; Protein Kinases, catalytic domain
  3. XM_006724633.3XP_006724696.1  nik-related protein kinase isoform X2

    Conserved Domains (3) summary
    smart00220
    Location:25313
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02434
    Location:12131501
    CNH; CNH domain
    cl21453
    Location:18313
    PKc_like; Protein Kinases, catalytic domain
  4. XM_006724634.4XP_006724697.1  nik-related protein kinase isoform X4

    Conserved Domains (3) summary
    smart00220
    Location:25313
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02434
    Location:12131493
    CNH; CNH domain
    cl21453
    Location:18313
    PKc_like; Protein Kinases, catalytic domain
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