U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sel1l sel-1 suppressor of lin-12-like (C. elegans) [ Mus musculus (house mouse) ]

Gene ID: 20338, updated on 17-Jun-2024

Summary

Official Symbol
Sel1lprovided by MGI
Official Full Name
sel-1 suppressor of lin-12-like (C. elegans)provided by MGI
Primary source
MGI:MGI:1329016
See related
Ensembl:ENSMUSG00000020964 AllianceGenome:MGI:1329016
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sel1h; mKIAA4137
Summary
Predicted to contribute to ubiquitin-protein transferase activity. Involved in ERAD pathway; protein secretion; and triglyceride metabolic process. Acts upstream of or within response to endoplasmic reticulum stress. Predicted to be located in endoplasmic reticulum. Predicted to be part of Derlin-1 retrotranslocation complex and Hrd1p ubiquitin ligase ERAD-L complex. Is expressed in several structures, including genitourinary system; liver; neural tube; pancreas; and spleen. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human SEL1L (SEL1L adaptor subunit of ERAD E3 ubiquitin ligase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 18.7), cortex adult (RPKM 16.8) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Sel1l in Genome Data Viewer
Location:
12 D3; 12 45.02 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (91772817..91815931, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (91806043..91849157, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene stonin 2 Neighboring gene VISTA enhancer mm815 Neighboring gene predicted gene, 16876 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:92984674-92984783 Neighboring gene STARR-positive B cell enhancer ABC_E8496 Neighboring gene predicted gene, 34718 Neighboring gene STARR-positive B cell enhancer ABC_E5346 Neighboring gene STARR-positive B cell enhancer ABC_E308 Neighboring gene signal recognition particle receptor ('docking protein') pseudogene Neighboring gene motile sperm domain containing 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA4137

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ERAD pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in protein secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in retrograde protein transport, ER to cytosol ISO
Inferred from Sequence Orthology
more info
 
involved_in triglyceride metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of Derlin-1 retrotranslocation complex ISO
Inferred from Sequence Orthology
more info
 
part_of Hrd1p ubiquitin ligase ERAD-L complex ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein sel-1 homolog 1
Names
Sel1 (suppressor of lin-12) 1 homolog
sel-1L
suppressor of lin-12-like protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039089.1NP_001034178.1  protein sel-1 homolog 1 isoform a precursor

    See identical proteins and their annotated locations for NP_001034178.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC157658, AK220502
    Consensus CDS
    CCDS26091.1
    UniProtKB/Swiss-Prot
    Q9DBD8, Q9Z2G6
    UniProtKB/TrEMBL
    Q5DTL8
    Related
    ENSMUSP00000021347.6, ENSMUST00000021347.12
    Conserved Domains (4) summary
    smart00059
    Location:116164
    FN2; Fibronectin type 2 domain
    smart00671
    Location:479514
    SEL1; Sel1-like repeats
    COG0790
    Location:183449
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:389418
    SLR; SLR repeat [structural motif]
  2. NM_011344.2NP_035474.1  protein sel-1 homolog 1 isoform b precursor

    See identical proteins and their annotated locations for NP_035474.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.
    Source sequence(s)
    AC157658, AK160936, AK220502
    Consensus CDS
    CCDS49137.1
    UniProtKB/TrEMBL
    Q5DTL8, Q6GTY4
    Related
    ENSMUSP00000129384.2, ENSMUST00000167466.2
    Conserved Domains (3) summary
    smart00671
    Location:429464
    SEL1; Sel1-like repeats
    COG0790
    Location:133464
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:339368
    SLR; SLR repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    91772817..91815931 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)