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Sec23a SEC23 homolog A, COPII coat complex component [ Mus musculus (house mouse) ]

Gene ID: 20334, updated on 5-Mar-2024

Summary

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Official Symbol
Sec23aprovided by MGI
Official Full Name
SEC23 homolog A, COPII coat complex componentprovided by MGI
Primary source
MGI:MGI:1349635
See related
Ensembl:ENSMUSG00000020986 AllianceGenome:MGI:1349635
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Msec23; Sec23r
Summary
Predicted to enable GTPase activator activity and zinc ion binding activity. Involved in protein localization to plasma membrane. Located in COPII-coated ER to Golgi transport vesicle; Golgi membrane; and perinuclear region of cytoplasm. Is expressed in central nervous system; craniocervical region bone; retina; and thoracic segment skeleton. Human ortholog(s) of this gene implicated in craniolenticulosutural dysplasia. Orthologous to human SEC23A (SEC23 homolog A, COPII coat complex component). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 26.3), limb E14.5 (RPKM 22.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Sec23a in Genome Data Viewer
Location:
12 C1; 12 25.97 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (59005170..59058803, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (58958384..59012017, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 pseudogene Neighboring gene STARR-seq mESC enhancer starr_32238 Neighboring gene STARR-seq mESC enhancer starr_32241 Neighboring gene STARR-positive B cell enhancer mm9_chr12:60021773-60022074 Neighboring gene STARR-seq mESC enhancer starr_32242 Neighboring gene PRELI domain containing 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_32243 Neighboring gene STARR-seq mESC enhancer starr_32244 Neighboring gene STARR-positive B cell enhancer ABC_E1154 Neighboring gene STARR-positive B cell enhancer ABC_E10751 Neighboring gene STARR-positive B cell enhancer mm9_chr12:60138923-60139223 Neighboring gene STARR-positive B cell enhancer mm9_chr12:60139247-60139547 Neighboring gene gem nuclear organelle associated protein 2 Neighboring gene predicted gene, 22973

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Activation of cytokine genes in T cells during primary and secondary murine influenza pneumonia. Carding SR, et al. J Exp Med, 1993 Feb 1. PMID 8426116, Free PMC Article
  2. Identification and differential expression of yeast SEC23-related gene (Msec23) in mouse tissues. Wadhwa R, et al. FEBS Lett, 1993 Jan 4. PMID 8417978
  3. Sterols block binding of COPII proteins to SCAP, thereby controlling SCAP sorting in ER. Espenshade PJ, et al. Proc Natl Acad Sci U S A, 2002 Sep 3. PMID 12193656, Free PMC Article
  4. p125 is a novel mammalian Sec23p-interacting protein with structural similarity to phospholipid-modifying proteins. Tani K, et al. J Biol Chem, 1999 Jul 16. PMID 10400679
  5. SEC23A Inhibit Melanoma Metastatic through Secretory PF4 Cooperation with SPARC to Inhibit MAPK Signaling Pathway. Zeng B, et al. Int J Biol Sci, 2021. PMID 34421345, Free PMC Article

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SEC23A Inhibit Melanoma Metastatic through Secretory PF4 Cooperation with SPARC to Inhibit MAPK Signaling Pathway.
    Title: SEC23A Inhibit Melanoma Metastatic through Secretory PF4 Cooperation with SPARC to Inhibit MAPK Signaling Pathway.
  2. these data demonstrate an equivalent function for SEC23A/B, with evolutionary shifts in the transcription program likely accounting for the distinct phenotypes of SEC23A/B deficiency within and across species, a paradigm potentially applicable to other sets of paralogous genes.
    Title: Functions of the COPII gene paralogs SEC23A and SEC23B are interchangeable in vivo.
  3. This study also validated the interaction between HAP1 and Sec23A using co-immunoprecipitation experiments with endogenous proteins. This manuscript also reports on the high confidence interacting partners of HAP1 identified by the non-biased approach used in this study, which interestingly, consists of predominantly trafficking-related proteins
    Title: Huntingtin-associated protein-1 (HAP1) regulates endocytosis and interacts with multiple trafficking-related proteins.
  4. results suggest that mammalian SEC23A and SEC23B transport overlapping yet distinct spectra of cargo in vivo
    Title: Neural tube opening and abnormal extraembryonic membrane development in SEC23A deficient mice.
  5. Sec23a contains consensus TFII-I binding sites in the proximal promoters; the chromatin immunoprecipitation analysis showed that TFII-I transcription factors are recruited to these sites in vivo in Williams-Beuren syndrome.
    Title: Molecular basis of Williams-Beuren syndrome: TFII-I regulated targets involved in craniofacial development.
  6. Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis.
    Title: Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in COPII-coated vesicle budding IEA
Inferred from Electronic Annotation
more info
  
involved_in COPII-coated vesicle cargo loading IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in COPII-coated vesicle cargo loading ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within intracellular protein transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of COPII vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COPII vesicle coat ISO
Inferred from Sequence Orthology
more info
  
located_in COPII-coated ER to Golgi transport vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ER to Golgi transport vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum exit site ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein transport protein Sec23A
Names
SEC23-related protein A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361956.1 → NP_001348885.1  protein transport protein Sec23A

    Status: VALIDATED

    Source sequence(s)
    AC153654, AY082671, BY760439, BY778724, BY789138
    Consensus CDS
    CCDS25931.1
    UniProtKB/Swiss-Prot
    Q01405, Q8JZL4
    UniProtKB/TrEMBL
    Q8C1E4
    Conserved Domains (1) summary
    PLN00162
    Location:12 → 763
    PLN00162; transport protein sec23; Provisional

  2. NM_009147.2 → NP_033173.2  protein transport protein Sec23A

    See identical proteins and their annotated locations for NP_033173.2

    Status: VALIDATED

    Source sequence(s)
    AK028152, BC034610, BY760439
    Consensus CDS
    CCDS25931.1
    UniProtKB/Swiss-Prot
    Q01405, Q8JZL4
    UniProtKB/TrEMBL
    Q8C1E4
    Related
    ENSMUSP00000021375.6, ENSMUST00000021375.12
    Conserved Domains (1) summary
    PLN00162
    Location:12 → 763
    PLN00162; transport protein sec23; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    59005170..59058803 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q01405.2 GenPept UniProtKB/Swiss-Prot:Q01405

Gene LinkOut

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