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CCDC107 coiled-coil domain containing 107 [ Homo sapiens (human) ]

Gene ID: 203260, updated on 17-Dec-2019

Summary

Official Symbol
CCDC107provided by HGNC
Official Full Name
coiled-coil domain containing 107provided by HGNC
Primary source
HGNC:HGNC:28465
See related
Ensembl:ENSG00000159884
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSEC0222
Summary
This gene encodes a membrane protein which contains a coiled-coil domain in the central region. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
Expression
Ubiquitous expression in fat (RPKM 29.1), adrenal (RPKM 11.8) and 25 other tissues See more
Orthologs

Genomic context

See CCDC107 in Genome Data Viewer
Location:
9p13.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (35658290..35661511)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (35658279..35661500)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene signaling threshold regulating transmembrane adaptor 1 Neighboring gene Rho guanine nucleotide exchange factor 39 Neighboring gene RNA component of mitochondrial RNA processing endoribonuclease Neighboring gene RNA, 7SL, cytoplasmic 22, pseudogene Neighboring gene carbonic anhydrase 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ97171, MGC31967

Gene Ontology Provided by GOA

Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
coiled-coil domain-containing protein 107

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033120.1 RefSeqGene

    Range
    5003..8222
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001195200.1NP_001182129.1  coiled-coil domain-containing protein 107 isoform B precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (B) lacks an in-frame segment in the 3' coding region, compared to variant A. This results in a shorter protein (isoform B), compared to isoform A.
    Source sequence(s)
    AL357874, BE903559, BM973388, DC410699
    Consensus CDS
    CCDS56573.1
    UniProtKB/Swiss-Prot
    Q8WV48
    Related
    ENSP00000367665.3, ENST00000378409.7
  2. NM_001195201.2NP_001182130.1  coiled-coil domain-containing protein 107 isoform C precursor

    See identical proteins and their annotated locations for NP_001182130.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (C) uses an alternate splice site and lacks an in-frame segment in the 3' region, compared to variant A. The usage of the alternate splice site results in a frameshift, and the encoded isoform (C) has a shorter and distinct C-terminus, compared to isoform A.
    Source sequence(s)
    AL357874, BC051285, BM973388, DC410699
    Consensus CDS
    CCDS56574.1
    UniProtKB/Swiss-Prot
    Q8WV48
    Related
    ENSP00000330327.2, ENST00000327351.6
  3. NM_001195217.2NP_001182146.1  coiled-coil domain-containing protein 107 isoform D precursor

    See identical proteins and their annotated locations for NP_001182146.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (D) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant A. It encodes isoform D, which has a shorter and distinct C-terminus, compared to isoform A.
    Source sequence(s)
    AK075523, AL357874, BM973388, DC410699
    Consensus CDS
    CCDS56575.1
    UniProtKB/Swiss-Prot
    Q8WV48
    Related
    ENSP00000367662.3, ENST00000378407.7
  4. NM_174923.3NP_777583.2  coiled-coil domain-containing protein 107 isoform A precursor

    See identical proteins and their annotated locations for NP_777583.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (A) represents the longest transcript and encodes the longest isoform (A).
    Source sequence(s)
    AL357874, BC018758, BM973388, DC410699
    Consensus CDS
    CCDS6583.1
    UniProtKB/Swiss-Prot
    Q8WV48
    Related
    ENSP00000414964.2, ENST00000426546.7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    35658290..35661511
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005251403.5XP_005251460.1  coiled-coil domain-containing protein 107 isoform X1

    See identical proteins and their annotated locations for XP_005251460.1

    Related
    ENSP00000367661.1, ENST00000378406.5

RNA

  1. XR_929218.3 RNA Sequence

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