U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

FAM219A family with sequence similarity 219 member A [ Homo sapiens (human) ]

Gene ID: 203259, updated on 9-Jun-2025
Official Symbol
FAM219Aprovided by HGNC
Official Full Name
family with sequence similarity 219 member Aprovided by HGNC
Primary source
HGNC:HGNC:19920
See related
Ensembl:ENSG00000164970 AllianceGenome:HGNC:19920
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C9orf25
Summary
The protein encoded by this gene has homologs that have been identified in mouse, macaque, etc organisms. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Dec 2010]
Expression
Broad expression in brain (RPKM 9.8), fat (RPKM 2.5) and 21 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table
See FAM219A in Genome Data Viewer
Location:
9p13.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (34398184..34458570, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (34416674..34477091, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (34398182..34458568, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34371826-34372326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34372327-34372827 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34375663-34376244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34376245-34376825 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34380811-34381416 Neighboring gene uncharacterized LOC124902144 Neighboring gene myogenesis regulating glycosidase Neighboring gene sperm microtubule inner protein 6 Neighboring gene uncharacterized LOC124902145 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19845 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34456734-34457234 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr9:34458366-34458906 Neighboring gene dynein axonemal intermediate chain 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34482439-34482941 Neighboring gene RN7SK pseudogene 24 Neighboring gene Sharpr-MPRA regulatory regions 5304 and 15183 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:34512715-34513467 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34521732-34522284 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19847 Neighboring gene energy homeostasis associated

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • FLJ39031

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Preferred Names
protein FAM219A
Names
uncharacterized protein C9orf25

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027971.1 RefSeqGene

    Range
    5001..65387
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184940.2NP_001171869.1  protein FAM219A isoform 1

    See identical proteins and their annotated locations for NP_001171869.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
    Source sequence(s)
    AK096350, AK299882, AL356494, BC025348
    Consensus CDS
    CCDS55304.1
    UniProtKB/Swiss-Prot
    A2A364, B4DFE1, B4DSR8, Q5T590, Q5T591, Q5T592, Q5T594, Q5T595, Q8IW50, Q8TAZ8
    UniProtKB/TrEMBL
    A0A0A0MRW3
    Related
    ENSP00000499069.1, ENST00000651358.1
    Conserved Domains (1) summary
    pfam15260
    Location:54182
    FAM219A; Protein family FAM219A
  2. NM_001184941.2NP_001171870.1  protein FAM219A isoform 2

    See identical proteins and their annotated locations for NP_001171870.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the coding region, compared to variant 1. The resulting protein (isoform 2) lacks an internal aa when it is compared to isoform 1.
    Source sequence(s)
    AK096350, AK299882, AL356494, BC025348
    UniProtKB/TrEMBL
    A0A0A0MRW3
    Related
    ENSP00000368382.1, ENST00000379089.5
    Conserved Domains (1) summary
    pfam15260
    Location:54181
    FAM219A; Protein family FAM219A
  3. NM_001184942.2NP_001171871.1  protein FAM219A isoform 3

    See identical proteins and their annotated locations for NP_001171871.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two different splice sites in the coding region, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK294054, AL356494, BC025348
    UniProtKB/TrEMBL
    A0A0A0MRW0
    Related
    ENSP00000368371.1, ENST00000379080.5
    Conserved Domains (1) summary
    pfam15260
    Location:43170
    FAM219A; Protein family FAM219A
  4. NM_001184943.2NP_001171872.1  protein FAM219A isoform 5

    See identical proteins and their annotated locations for NP_001171872.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses two different splice sites in the coding region, compared to variant 1. The resulting protein (isoform 5) lacks a segment in the N-terminal region and an internal aa when it is compared to isoform 1.
    Source sequence(s)
    AK096350, AL356494, BC025348, DA110626
    UniProtKB/TrEMBL
    A0A0A0MRW2
    Related
    ENSP00000368380.1, ENST00000379087.5
    Conserved Domains (1) summary
    pfam15260
    Location:37164
    FAM219A; Protein family FAM219A
  5. NM_001184945.2NP_001171874.1  protein FAM219A isoform 7

    See identical proteins and their annotated locations for NP_001171874.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses three different splice sites in the coding region, compared to variant 1. The resulting protein (isoform 7) lacks two segments and an internal aa when it is compared to isoform 1.
    Source sequence(s)
    AK294054, AL356494, BC025348, BC041009
    UniProtKB/TrEMBL
    A0A0A0MRW1
    Related
    ENSP00000368372.1, ENST00000379081.5
    Conserved Domains (1) summary
    pfam15260
    Location:26153
    FAM219A; Protein family FAM219A
  6. NM_147202.2NP_671735.1  protein FAM219A isoform 4

    See identical proteins and their annotated locations for NP_671735.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses a different splice site in the coding region, compared to variant 1. The resulting protein (isoform 4) lacks an internal segment when it is compared to isoform 1.
    Source sequence(s)
    AK096350, AL356494, BC025348
    Consensus CDS
    CCDS6556.1
    UniProtKB/TrEMBL
    A0A0A0MRW2
    Related
    ENSP00000297620.4, ENST00000297620.8
    Conserved Domains (1) summary
    pfam15260
    Location:37165
    FAM219A; Protein family FAM219A

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    34398184..34458570 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    34416674..34477091 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001184944.1: Suppressed sequence

    Description
    NM_001184944.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.