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LGI3 leucine rich repeat LGI family member 3 [ Homo sapiens (human) ]

Gene ID: 203190, updated on 22-Aug-2020

Summary

Official Symbol
LGI3provided by HGNC
Official Full Name
leucine rich repeat LGI family member 3provided by HGNC
Primary source
HGNC:HGNC:18711
See related
Ensembl:ENSG00000168481 MIM:608302
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LGIL4
Expression
Biased expression in brain (RPKM 29.1), lung (RPKM 12.3) and 4 other tissues See more
Orthologs

Genomic context

See LGI3 in Genome Data Viewer
Location:
8p21.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (22146830..22156806, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (22004343..22014344, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene HR lysine demethylase and nuclear receptor corepressor Neighboring gene receptor accessory protein 4 Neighboring gene surfactant protein C Neighboring gene bone morphogenetic protein 1 Neighboring gene Sharpr-MPRA regulatory region 2962

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
GeneReviews: Not available

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
exocytosis IEA
Inferred from Electronic Annotation
more info
 
regulation of exocytosis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
neuron projection IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leucine-rich repeat LGI family member 3
Names
LGI1-like protein 4
leucine-rich glioma-inactivated protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139278.4NP_644807.1  leucine-rich repeat LGI family member 3 precursor

    See identical proteins and their annotated locations for NP_644807.1

    Status: VALIDATED

    Source sequence(s)
    AC105206
    Consensus CDS
    CCDS6025.1
    UniProtKB/Swiss-Prot
    Q8N145
    Related
    ENSP00000302297.2, ENST00000306317.7
    Conserved Domains (6) summary
    smart00370
    Location:135158
    LRR; Leucine-rich repeats, outliers
    smart00082
    Location:170218
    LRRCT; Leucine rich repeat C-terminal domain
    sd00031
    Location:6889
    LRR_1; leucine-rich repeat [structural motif]
    pfam03736
    Location:222263
    EPTP; EPTP domain
    pfam12799
    Location:113152
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:112172
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    22146830..22156806 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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