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Serpinf1 serine (or cysteine) peptidase inhibitor, clade F, member 1 [ Mus musculus (house mouse) ]

Gene ID: 20317, updated on 21-Apr-2024

Summary

Official Symbol
Serpinf1provided by MGI
Official Full Name
serine (or cysteine) peptidase inhibitor, clade F, member 1provided by MGI
Primary source
MGI:MGI:108080
See related
Ensembl:ENSMUSG00000000753 AllianceGenome:MGI:108080
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pedf; Sdf3; EPC-1; Pedfl
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Involved in negative regulation of angiogenesis. Acts upstream of or within negative regulation of epithelial cell proliferation involved in prostate gland development. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Used to study osteogenesis imperfecta type 6. Human ortholog(s) of this gene implicated in several diseases, including brain edema; eye disease (multiple); leukostasis; non-alcoholic steatohepatitis; and osteogenesis imperfecta type 6. Orthologous to human SERPINF1 (serpin family F member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 193.9), mammary gland adult (RPKM 118.2) and 10 other tissues See more
Orthologs
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Genomic context

Location:
11 B5; 11 45.87 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (75300855..75313449, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (75410029..75422623, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene reticulon 4 receptor-like 1 Neighboring gene predicted gene, 35117 Neighboring gene replication protein A1 Neighboring gene STARR-positive B cell enhancer ABC_E9826 Neighboring gene STARR-positive B cell enhancer ABC_E3972 Neighboring gene STARR-seq mESC enhancer starr_29990 Neighboring gene STARR-seq mESC enhancer starr_29991 Neighboring gene SET and MYND domain containing 4 Neighboring gene predicted gene, 35337 Neighboring gene predicted gene 12337

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in axon hillock ISO
Inferred from Sequence Orthology
more info
 
located_in basement membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
pigment epithelium-derived factor
Names
SDF-3
alpha-2 antiplasmin
caspin
serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
serine (or cysteine) proteinase inhibitor, clade F), member 1
serine (or cysteine) proteinase inhibitor, clade F, member 1
serpin F1
stromal cell-derived factor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011340.3NP_035470.3  pigment epithelium-derived factor precursor

    See identical proteins and their annotated locations for NP_035470.3

    Status: VALIDATED

    Source sequence(s)
    AA111321, AF017057, AL591496, D50460
    Consensus CDS
    CCDS25045.1
    UniProtKB/Swiss-Prot
    O70629, O88691, P97298
    Related
    ENSMUSP00000000769.8, ENSMUST00000000769.14
    Conserved Domains (1) summary
    cd02052
    Location:39414
    PEDF; Pigment epithelium-derived factor (PEDF)_like. PEDF is non-inhibitory member of the Serpin superfamily. It exhibits neurotrophic, neuroprotective and antiangiogenic properties and is widely expressed in the developing and adult nervous systems. This ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    75300855..75313449 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)