U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ADAM32 ADAM metallopeptidase domain 32 [ Homo sapiens (human) ]

Gene ID: 203102, updated on 17-Jun-2024

Summary

Official Symbol
ADAM32provided by HGNC
Official Full Name
ADAM metallopeptidase domain 32provided by HGNC
Primary source
HGNC:HGNC:15479
See related
Ensembl:ENSG00000197140 MIM:618602; AllianceGenome:HGNC:15479
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the disintegrin family of membrane-anchored proteins that play a role in diverse biological processes such as brain development, fertilization, tumor development and inflammation. This gene is predominantly expressed in the testis. The encoded protein undergoes proteolytic processing to generate a mature polypeptide comprised of an metalloprotease, disintegrin and epidermal growth factor-like domains. This gene is located in a cluster of other disintegrin and metallopeptidase family genes on chromosome 8. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Expression
Restricted expression toward testis (RPKM 20.2) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ADAM32 in Genome Data Viewer
Location:
8p11.22
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (39107529..39284917)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (39384664..39562013)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (38965048..39142436)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38853156-38853678 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38853679-38854200 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27274 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27275 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19140 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27277 Neighboring gene TM2 domain containing 2 Neighboring gene Sharpr-MPRA regulatory region 279 Neighboring gene ADAM metallopeptidase domain 9 Neighboring gene small nucleolar RNA, C/D box 38D Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:39038237-39039436 Neighboring gene ribosomal protein L3 pseudogene 10 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:39084432-39085631 Neighboring gene lysine acetyltransferase 2B pseudogene Neighboring gene ADAM metallopeptidase domain 5 (pseudogene)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ26299, FLJ29004

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in binding of sperm to zona pellucida IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in male gonad development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
disintegrin and metalloproteinase domain-containing protein 32
Names
a disintegrin and metalloprotease domain 32
a disintegrin and metalloproteinase domain 32
metalloproteinase 12-like protein
testicular tissue protein Li 13

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313994.1NP_001300923.1  disintegrin and metalloproteinase domain-containing protein 32 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks multiple alternate exons in the coding region and uses an alternate translation start site, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AC105091, AK300148, BC026169, BI559590
    Consensus CDS
    CCDS83286.1
    UniProtKB/TrEMBL
    B4DTC2, E7EPX8
    Related
    ENSP00000405978.2, ENST00000437682.6
    Conserved Domains (5) summary
    cd04269
    Location:194312
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:313376
    Disintegrin; Disintegrin
    pfam01562
    Location:45150
    Pep_M12B_propep; Reprolysin family propeptide
    pfam08516
    Location:380494
    ADAM_CR; ADAM cysteine-rich
    pfam14797
    Location:615687
    SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex
  2. NM_145004.7NP_659441.4  disintegrin and metalloproteinase domain-containing protein 32 isoform 1 preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC105091, AC105185
    Consensus CDS
    CCDS47846.1
    UniProtKB/Swiss-Prot
    Q8TC27, Q8TC42
    UniProtKB/TrEMBL
    A0A140VJD9
    Related
    ENSP00000369238.4, ENST00000379907.9
    Conserved Domains (5) summary
    pfam00200
    Location:400474
    Disintegrin; Disintegrin
    pfam01421
    Location:187383
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:27144
    Pep_M12B_propep; Reprolysin family propeptide
    pfam08516
    Location:479593
    ADAM_CR; ADAM cysteine-rich
    pfam14797
    Location:714786
    SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    39107529..39284917
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544433.3XP_011542735.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X2

    UniProtKB/TrEMBL
    A0A140VJD9
    Conserved Domains (6) summary
    cd04269
    Location:187381
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:400475
    Disintegrin; Disintegrin
    pfam01421
    Location:187383
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:40143
    Pep_M12B_propep; Reprolysin family propeptide
    pfam08516
    Location:479593
    ADAM_CR; ADAM cysteine-rich
    pfam14797
    Location:714773
    SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex
  2. XM_006716298.4XP_006716361.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X1

    UniProtKB/TrEMBL
    A0A140VJD9
    Conserved Domains (5) summary
    cd04269
    Location:187381
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:400475
    Disintegrin; Disintegrin
    pfam01421
    Location:187383
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:40143
    Pep_M12B_propep; Reprolysin family propeptide
    pfam08516
    Location:479593
    ADAM_CR; ADAM cysteine-rich
  3. XM_017013184.3XP_016868673.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X4

    UniProtKB/TrEMBL
    A0A140VJD9
  4. XM_006716299.3XP_006716362.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X7

    UniProtKB/TrEMBL
    E7ER82
    Related
    ENSP00000429422.1, ENST00000519315.5
    Conserved Domains (5) summary
    cd04269
    Location:187305
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:306369
    Disintegrin; Disintegrin
    pfam01562
    Location:40143
    Pep_M12B_propep; Reprolysin family propeptide
    pfam08516
    Location:373487
    ADAM_CR; ADAM cysteine-rich
    pfam14797
    Location:608680
    SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex
  5. XM_011544434.3XP_011542736.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X6

    UniProtKB/TrEMBL
    E7ER82
    Conserved Domains (6) summary
    cd04269
    Location:187308
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:327402
    Disintegrin; Disintegrin
    pfam01421
    Location:187310
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:40143
    Pep_M12B_propep; Reprolysin family propeptide
    pfam08516
    Location:406520
    ADAM_CR; ADAM cysteine-rich
    pfam14797
    Location:641713
    SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex
  6. XM_017013183.3XP_016868672.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X3

    UniProtKB/TrEMBL
    A0A140VJD9
  7. XM_047421494.1XP_047277450.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X9

    UniProtKB/TrEMBL
    E7ER82
  8. XM_017013186.3XP_016868675.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X8

  9. XM_017013185.3XP_016868674.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X5

    UniProtKB/TrEMBL
    A0A140VJD9
  10. XM_017013188.2XP_016868677.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X11

  11. XM_017013187.2XP_016868676.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X10

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187577.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    13212..190632
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328846.1XP_054184821.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X2

    UniProtKB/TrEMBL
    A0A140VJD9
  2. XM_054328845.1XP_054184820.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X1

    UniProtKB/TrEMBL
    A0A140VJD9
  3. XM_054328848.1XP_054184823.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X4

    UniProtKB/TrEMBL
    A0A140VJD9
  4. XM_054328851.1XP_054184826.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X7

    UniProtKB/TrEMBL
    A0A0G2JPC8
  5. XM_054328852.1XP_054184827.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X12

    UniProtKB/TrEMBL
    A0A0G2JPC8
  6. XM_054328850.1XP_054184825.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X6

    UniProtKB/TrEMBL
    A0A0G2JPC8
  7. XM_054328847.1XP_054184822.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X3

    UniProtKB/TrEMBL
    A0A140VJD9
  8. XM_054328854.1XP_054184829.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X9

    UniProtKB/TrEMBL
    A0A0G2JPC8
  9. XM_054328853.1XP_054184828.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X8

  10. XM_054328849.1XP_054184824.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X5

    UniProtKB/TrEMBL
    A0A140VJD9
  11. XM_054328857.1XP_054184832.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X11

  12. XM_054328855.1XP_054184830.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X10

  13. XM_054328856.1XP_054184831.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X13

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    39384664..39562013
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054360000.1XP_054215975.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X2

    UniProtKB/TrEMBL
    A0A140VJD9
  2. XM_054359999.1XP_054215974.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X1

    UniProtKB/TrEMBL
    A0A140VJD9
  3. XM_054360002.1XP_054215977.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X4

    UniProtKB/TrEMBL
    A0A140VJD9
  4. XM_054360005.1XP_054215980.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X7

    UniProtKB/TrEMBL
    A0A0G2JPC8
  5. XM_054360006.1XP_054215981.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X14

    UniProtKB/TrEMBL
    A0A0G2JPC8
  6. XM_054360004.1XP_054215979.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X6

    UniProtKB/TrEMBL
    A0A0G2JPC8
  7. XM_054360001.1XP_054215976.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X3

    UniProtKB/TrEMBL
    A0A140VJD9
  8. XM_054360008.1XP_054215983.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X9

    UniProtKB/TrEMBL
    A0A0G2JPC8
  9. XM_054360007.1XP_054215982.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X8

  10. XM_054360003.1XP_054215978.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X5

    UniProtKB/TrEMBL
    A0A140VJD9
  11. XM_054360010.1XP_054215985.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X11

  12. XM_054360009.1XP_054215984.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X10