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HTRA4 HtrA serine peptidase 4 [ Homo sapiens (human) ]

Gene ID: 203100, updated on 8-Aug-2021

Summary

Official Symbol
HTRA4provided by HGNC
Official Full Name
HtrA serine peptidase 4provided by HGNC
Primary source
HGNC:HGNC:26909
See related
Ensembl:ENSG00000169495 MIM:610700
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the HtrA family of proteases. The encoded protein contains a putative signal peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies on other related family members, this enzyme may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, apoptosis, and aging. [provided by RefSeq, Oct 2008]
Expression
Biased expression in placenta (RPKM 16.9) and bone marrow (RPKM 1.2) See more
Orthologs
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Genomic context

See HTRA4 in Genome Data Viewer
Location:
8p11.22
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (38974149..38988663)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (38831747..38846182)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene transforming acidic coiled-coil containing protein 1 Neighboring gene Sharpr-MPRA regulatory region 13542 Neighboring gene pleckstrin homology domain containing A2 Neighboring gene TM2 domain containing 2 Neighboring gene ADAM metallopeptidase domain 9 Neighboring gene small nucleolar RNA, C/D box 38D

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ90724

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables insulin-like growth factor binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine protease HTRA4
Names
high-temperature requirement factor A4
probable serine protease HTRA4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153692.4NP_710159.1  serine protease HTRA4 precursor

    See identical proteins and their annotated locations for NP_710159.1

    Status: REVIEWED

    Source sequence(s)
    AC108863, AK075205, AY188774
    Consensus CDS
    CCDS6110.1
    UniProtKB/Swiss-Prot
    P83105
    Related
    ENSP00000305919.4, ENST00000302495.5
    Conserved Domains (5) summary
    COG0265
    Location:156470
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00987
    Location:380470
    PDZ_serine_protease; PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind ...
    pfam00219
    Location:4094
    IGFBP; Insulin-like growth factor binding protein
    pfam07648
    Location:108152
    Kazal_2; Kazal-type serine protease inhibitor domain
    pfam13365
    Location:202340
    Trypsin_2; Trypsin-like peptidase domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    38974149..38988663
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544431.2XP_011542733.1  serine protease HTRA4 isoform X1

    Conserved Domains (3) summary
    pfam00219
    Location:4094
    IGFBP; Insulin-like growth factor binding protein
    pfam07648
    Location:108152
    Kazal_2; Kazal-type serine protease inhibitor domain
    pfam13365
    Location:202340
    Trypsin_2; Trypsin-like peptidase domain
  2. XM_011544432.1XP_011542734.1  serine protease HTRA4 isoform X2

    Conserved Domains (3) summary
    pfam00219
    Location:4094
    IGFBP; Insulin-like growth factor binding protein
    pfam07648
    Location:108152
    Kazal_2; Kazal-type serine protease inhibitor domain
    pfam13365
    Location:202332
    Trypsin_2; Trypsin-like peptidase domain
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