U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

C8orf74 chromosome 8 open reading frame 74 [ Homo sapiens (human) ]

Gene ID: 203076, updated on 9-Jun-2025
Official Symbol
C8orf74provided by HGNC
Official Full Name
chromosome 8 open reading frame 74provided by HGNC
Primary source
HGNC:HGNC:32296
See related
Ensembl:ENSG00000171060 AllianceGenome:HGNC:32296
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Restricted expression toward testis (RPKM 4.0) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table
See C8orf74 in Genome Data Viewer
Location:
8p23.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (10672628..10700590)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (9038498..9066367, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (10530138..10558100)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:10469845-10470570 Neighboring gene MPRA-validated peak6901 silencer Neighboring gene RP1 like 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26993 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:10489151-10489860 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:10493333-10494238 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:10494239-10495144 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:10503027-10503883 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:10535715-10536216 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:10536217-10536716 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:10536733-10537272 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:10537273-10537810 Neighboring gene microRNA 4286 Neighboring gene RNA, 5S ribosomal pseudogene 252 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:10567701-10568468 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:10568469-10569236 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18914 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18915 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:10589078-10589902 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:10591664-10592306 Neighboring gene CRE3 CAGE-defined tissue-specific enhancer Neighboring gene SOX7 antisense RNA 1 Neighboring gene SRY-box transcription factor 7 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:10616720-10616853 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:10632670-10632869 Neighboring gene PIN2 (TERF1) interacting telomerase inhibitor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:10647506-10648006 Neighboring gene microRNA 1322

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Preferred Names
uncharacterized protein C8orf74

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040032.2NP_001035121.2  uncharacterized protein C8orf74

    Status: VALIDATED

    Source sequence(s)
    AC105001
    Consensus CDS
    CCDS47800.1
    UniProtKB/Swiss-Prot
    A2RUD6, Q6P047
    UniProtKB/TrEMBL
    A0AAG2TK55
    Related
    ENSP00000307129.5, ENST00000304519.10
    Conserved Domains (1) summary
    pfam14769
    Location:102129
    CLAMP; Flagellar C1a complex subunit C1a-32

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    10672628..10700590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421493.1XP_047277449.1  uncharacterized protein C8orf74 isoform X1

    UniProtKB/TrEMBL
    A0AAG2TK55

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654717.1 Reference GRCh38.p14 PATCHES

    Range
    2646603..2674481 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332240.1XP_054188215.1  uncharacterized protein C8orf74 isoform X2

    UniProtKB/TrEMBL
    A0AAG2TK55

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    9038498..9066367 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054359996.1XP_054215971.1  uncharacterized protein C8orf74 isoform X3

    UniProtKB/TrEMBL
    A0AAG2TK55