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TUBB tubulin beta class I [ Homo sapiens (human) ]

Gene ID: 203068, updated on 5-Sep-2021

Summary

Official Symbol
TUBBprovided by HGNC
Official Full Name
tubulin beta class Iprovided by HGNC
Primary source
HGNC:HGNC:20778
See related
Ensembl:ENSG00000196230 MIM:191130
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
M40; TUBB1; TUBB5; CDCBM6; CSCSC1; OK/SW-cl.56
Summary
This gene encodes a beta tubulin protein. This protein forms a dimer with alpha tubulin and acts as a structural component of microtubules. Mutations in this gene cause cortical dysplasia, complex, with other brain malformations 6. Alternative splicing results in multiple splice variants. There are multiple pseudogenes for this gene on chromosomes 1, 6, 7, 8, 9, and 13. [provided by RefSeq, Jun 2014]
Annotation information
Note: TUBB1 (Gene ID: 81027) and TUBB (Gene ID: 203068) share the TUBB1 symbol/alias in common. TUBB (GeneID: 203068) also shares the TUBB symbol/alias in common with TUBB2A (Gene ID: 7280). [07 Feb 2019]
Expression
Ubiquitous expression in ovary (RPKM 250.9), bone marrow (RPKM 212.6) and 25 other tissues See more
Orthologs
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Genomic context

See TUBB in Genome Data Viewer
Location:
6p21.33
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (30720352..30725422)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30688129..30693199)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7 pseudogene 4 Neighboring gene mediator of DNA damage checkpoint 1 Neighboring gene MDC1 antisense RNA 1 Neighboring gene flotillin 1 Neighboring gene IER3 antisense RNA 1 Neighboring gene immediate early response 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Treatment of cells with actin-depolymerizing agents or tubulin polymerization inhibitors largely reduces the percentage of cells with capped HIV-1 Gag and Env, indicating an intact actin and tubulin cytoskeleton is required for efficient assembly of HIV-1 PubMed
Pr55(Gag) gag Treatment of cells with actin-depolymerizing agents or tubulin polymerization inhibitors largely reduces the percentage of cells with capped HIV-1 Gag and Env, indicating an intact actin and tubulin cytoskeleton is required for efficient assembly of HIV-1 PubMed
Rev rev HIV-1 Rev interacting protein, tubulin beta class I, is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
Tat tat HIV-1 Tat K29A, K50R, and K51R lysine mutations downregulate the proportion of soluble tubulin in cells, while the majority of other lysine mutations upregulate the percentage of soluble tubulin compared with the wild-type PubMed
tat In Jurkat cells expressing HIV-1 Tat, decreased expression levels are found for basic cytoskeletal proteins such as actin, beta-tubulin, annexin, cofilin, gelsolin, and Rac/Rho-GDI complex PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC16435, MGC117247

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activating protein binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables MHC class I protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables structural molecule activity TAS
Traceable Author Statement
more info
 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell division TAS
Traceable Author Statement
more info
 
involved_in cellular process IDA
Inferred from Direct Assay
more info
 
involved_in cytoskeleton-dependent intracellular transport TAS
Traceable Author Statement
more info
 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in microtubule-based process TAS
Traceable Author Statement
more info
 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in natural killer cell mediated cytotoxicity NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of synapse organization IEA
Inferred from Electronic Annotation
more info
 
involved_in spindle assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in azurophil granule lumen TAS
Traceable Author Statement
more info
 
located_in cell body IDA
Inferred from Direct Assay
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in microtubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule TAS
Traceable Author Statement
more info
 
located_in nuclear envelope lumen IDA
Inferred from Direct Assay
more info
 
located_in nucleus HDA PubMed 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tubulin beta chain
Names
beta Ib tubulin
epididymis secretory sperm binding protein
tubulin beta-1 chain
tubulin beta-5 chain
tubulin, beta polypeptide

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034142.1 RefSeqGene

    Range
    5152..10222
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001293212.2NP_001280141.1  tubulin beta chain isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK302314, BC013374, DC353572
    UniProtKB/Swiss-Prot
    P07437
    UniProtKB/TrEMBL
    B4DY90
    Related
    ENSP00000379672.1, ENST00000396389.5
    Conserved Domains (2) summary
    PLN00220
    Location:39449
    PLN00220; tubulin beta chain; Provisional
    cd02187
    Location:39446
    beta_tubulin; The beta-tubulin family
  2. NM_001293213.2NP_001280142.1  tubulin beta chain isoform c

    See identical proteins and their annotated locations for NP_001280142.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences, compared to variant 1. It initiates translation at an alternate start codon and lacks an in-frame portion of the 3' coding region. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AK297489, BC013374, DC366174
    UniProtKB/Swiss-Prot
    P07437
    UniProtKB/TrEMBL
    B4DMJ5
    Conserved Domains (1) summary
    PTZ00010
    Location:1227
    PTZ00010; tubulin beta chain; Provisional
  3. NM_001293214.2NP_001280143.1  tubulin beta chain isoform d

    See identical proteins and their annotated locations for NP_001280143.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (d) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    BC013374, DC366174, DC389555
    UniProtKB/Swiss-Prot
    P07437
    Conserved Domains (1) summary
    PLN00220
    Location:1385
    PLN00220; tubulin beta chain; Provisional
  4. NM_001293215.2NP_001280144.1  tubulin beta chain isoform e

    See identical proteins and their annotated locations for NP_001280144.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks a portion of the 5' coding region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (e) has a shorter N-terminus than isoform a. Variants 5 and 6 encode the same isoform (e).
    Source sequence(s)
    AK298889, BC013374, DC353572
    Consensus CDS
    CCDS78124.1
    UniProtKB/Swiss-Prot
    P07437
    UniProtKB/TrEMBL
    B4DQN9, Q5ST81
    Related
    ENSP00000365578.2, ENST00000330914.7
    Conserved Domains (1) summary
    PLN00220
    Location:1357
    PLN00220; tubulin beta chain; Provisional
  5. NM_001293216.2NP_001280145.1  tubulin beta chain isoform e

    See identical proteins and their annotated locations for NP_001280145.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks a portion of the 5' coding region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (e) has a shorter N-terminus than isoform a. Variants 5 and 6 encode the same isoform (e).
    Source sequence(s)
    AL662797, BC013374, DC405540
    Consensus CDS
    CCDS78124.1
    UniProtKB/Swiss-Prot
    P07437
    UniProtKB/TrEMBL
    Q5ST81
    Related
    ENSP00000506665.1, ENST00000681435.1
    Conserved Domains (1) summary
    PLN00220
    Location:1357
    PLN00220; tubulin beta chain; Provisional
  6. NM_178014.4NP_821133.1  tubulin beta chain isoform b

    See identical proteins and their annotated locations for NP_821133.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    BC013374, DC366174
    Consensus CDS
    CCDS4687.1
    UniProtKB/Swiss-Prot
    P07437
    UniProtKB/TrEMBL
    Q5SU16
    Related
    ENSP00000339001.7, ENST00000327892.13
    Conserved Domains (1) summary
    PLN00220
    Location:1429
    PLN00220; tubulin beta chain; Provisional

RNA

  1. NR_120608.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has multiple differences at the 5' and 3' ends, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    BC013374, BE245819, DC366174

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    30720352..30725422
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    2049855..2054925
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    2200091..2205161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p13 ALT_REF_LOCI_3

    Range
    1976202..1981272
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p13 ALT_REF_LOCI_4

    Range
    2030603..2035673
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p13 ALT_REF_LOCI_5

    Range
    2064427..2069497
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p13 ALT_REF_LOCI_6

    Range
    1975464..1980535
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p13 ALT_REF_LOCI_7

    Range
    2021138..2026208
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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