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TSNARE1 t-SNARE domain containing 1 [ Homo sapiens (human) ]

Gene ID: 203062, updated on 5-Jan-2022

Summary

Official Symbol
TSNARE1provided by HGNC
Official Full Name
t-SNARE domain containing 1provided by HGNC
Primary source
HGNC:HGNC:26437
See related
Ensembl:ENSG00000171045
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in intracellular protein transport; vesicle docking; and vesicle fusion. Predicted to be located in membrane. Predicted to be part of SNARE complex. Predicted to be active in endomembrane system. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in skin (RPKM 3.2), ovary (RPKM 2.2) and 25 other tissues See more
Orthologs
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Genomic context

See TSNARE1 in Genome Data Viewer
Location:
8q24.3
Exon count:
24
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (142212080..142403291, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (143293441..143484543, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375792 Neighboring gene Sharpr-MPRA regulatory region 1162 Neighboring gene long intergenic non-protein coding RNA 51 Neighboring gene uncharacterized LOC107986983 Neighboring gene RNA, 7SL, cytoplasmic 260, pseudogene Neighboring gene adhesion G protein-coupled receptor B1 Neighboring gene maestro heat like repeat family member 4, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Biological insights from 108 schizophrenia-associated genetic loci.
GeneReviews: Not available
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31164, MGC142116

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
t-SNARE domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291931.2NP_001278860.1  t-SNARE domain-containing protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two consecutive in-frame exons in the 5' coding region, uses an alternate in-frame splice site in the central coding region, and also lacks two 3' exons but contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC103758, AI203371, BC065226, BF529741, BX115133, HY009343, HY264564
    Consensus CDS
    CCDS78369.1
    UniProtKB/TrEMBL
    E5RHT3, Q6P186
    Related
    ENSP00000429679.1, ENST00000519651.5
    Conserved Domains (2) summary
    pfam14523
    Location:46146
    Syntaxin_2; Syntaxin-like protein
    cl22856
    Location:197260
    SNARE; SNARE motif
  2. NM_001363740.2NP_001350669.1  t-SNARE domain-containing protein 1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC103758, AC134682, AK055726, BC126343
    Consensus CDS
    CCDS87630.1
    Related
    ENSP00000303437.4, ENST00000307180.4
    Conserved Domains (3) summary
    cd15877
    Location:417480
    SNARE_TSNARE1; SNARE motif of TSNARE1
    pfam13873
    Location:124201
    Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain
    pfam14523
    Location:265366
    Syntaxin_2; Syntaxin-like protein
  3. NM_001366901.1NP_001353830.1  t-SNARE domain-containing protein 1 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC103758, AC134682, BC143684
    Conserved Domains (3) summary
    cd15877
    Location:415478
    SNARE_TSNARE1; SNARE motif of TSNARE1
    pfam13873
    Location:124201
    Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain
    pfam14523
    Location:265365
    Syntaxin_2; Syntaxin-like protein
  4. NM_001366902.1NP_001353831.1  t-SNARE domain-containing protein 1 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC103758, AC129918, AC134682
    Conserved Domains (2) summary
    pfam13873
    Location:124201
    Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain
    pfam14523
    Location:265366
    Syntaxin_2; Syntaxin-like protein
  5. NM_001366903.1NP_001353832.1  t-SNARE domain-containing protein 1 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC103758, AC129918, AC134682
    Conserved Domains (2) summary
    pfam13873
    Location:124201
    Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain
    pfam14523
    Location:265365
    Syntaxin_2; Syntaxin-like protein
  6. NM_001366904.1NP_001353833.1  t-SNARE domain-containing protein 1 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC103758, AC129918, AC134682, KC877361
    Conserved Domains (3) summary
    cd15877
    Location:416479
    SNARE_TSNARE1; SNARE motif of TSNARE1
    pfam13873
    Location:124201
    Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain
    pfam14523
    Location:265366
    Syntaxin_2; Syntaxin-like protein
  7. NM_145003.5NP_659440.2  t-SNARE domain-containing protein 1 isoform a

    See identical proteins and their annotated locations for NP_659440.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (a).
    Source sequence(s)
    AC103758, AK055726, BC113556, HY009343
    Consensus CDS
    CCDS6384.1
    UniProtKB/Swiss-Prot
    Q96NA8
    Related
    ENSP00000428763.2, ENST00000524325.6
    Conserved Domains (3) summary
    cd15877
    Location:416479
    SNARE_TSNARE1; SNARE motif of TSNARE1
    pfam13873
    Location:124201
    Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain
    pfam14523
    Location:265366
    Syntaxin_2; Syntaxin-like protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    142212080..142403291 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013176.1XP_016868665.1  t-SNARE domain-containing protein 1 isoform X8

  2. XM_011516913.2XP_011515215.1  t-SNARE domain-containing protein 1 isoform X5

    Conserved Domains (3) summary
    pfam13873
    Location:124198
    Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain
    pfam14523
    Location:265365
    Syntaxin_2; Syntaxin-like protein
    cl22856
    Location:416456
    SNARE; SNARE motif
  3. XM_011516912.2XP_011515214.1  t-SNARE domain-containing protein 1 isoform X4

    Conserved Domains (3) summary
    pfam13873
    Location:124198
    Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain
    pfam14523
    Location:265366
    Syntaxin_2; Syntaxin-like protein
    cl22856
    Location:416456
    SNARE; SNARE motif
  4. XM_011516916.1XP_011515218.1  t-SNARE domain-containing protein 1 isoform X3

    See identical proteins and their annotated locations for XP_011515218.1

    Conserved Domains (3) summary
    pfam13873
    Location:124198
    Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain
    pfam14523
    Location:265366
    Syntaxin_2; Syntaxin-like protein
    cl22856
    Location:417457
    SNARE; SNARE motif
  5. XM_011516915.2XP_011515217.1  t-SNARE domain-containing protein 1 isoform X2

    Conserved Domains (3) summary
    pfam13873
    Location:140214
    Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain
    pfam14523
    Location:281382
    Syntaxin_2; Syntaxin-like protein
    cl22856
    Location:433473
    SNARE; SNARE motif
  6. XM_011516914.1XP_011515216.1  t-SNARE domain-containing protein 1 isoform X1

    Conserved Domains (3) summary
    pfam13873
    Location:151225
    Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain
    pfam14523
    Location:292393
    Syntaxin_2; Syntaxin-like protein
    cl22856
    Location:444484
    SNARE; SNARE motif
  7. XM_011516917.2XP_011515219.1  t-SNARE domain-containing protein 1 isoform X3

    See identical proteins and their annotated locations for XP_011515219.1

    Conserved Domains (3) summary
    pfam13873
    Location:124198
    Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain
    pfam14523
    Location:265366
    Syntaxin_2; Syntaxin-like protein
    cl22856
    Location:417457
    SNARE; SNARE motif
  8. XM_011516920.1XP_011515222.1  t-SNARE domain-containing protein 1 isoform X10

    Conserved Domains (3) summary
    pfam13873
    Location:280352
    Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain
    pfam14523
    Location:46147
    Syntaxin_2; Syntaxin-like protein
    cl22856
    Location:198238
    SNARE; SNARE motif
  9. XM_011516918.1XP_011515220.1  t-SNARE domain-containing protein 1 isoform X6

    Conserved Domains (3) summary
    pfam13873
    Location:74148
    Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain
    pfam14523
    Location:215316
    Syntaxin_2; Syntaxin-like protein
    cl22856
    Location:367407
    SNARE; SNARE motif
  10. XM_011516923.2XP_011515225.1  t-SNARE domain-containing protein 1 isoform X17

    Conserved Domains (3) summary
    pfam13873
    Location:181253
    Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain
    pfam14523
    Location:548
    Syntaxin_2; Syntaxin-like protein
    cl22856
    Location:99139
    SNARE; SNARE motif
  11. XM_017013179.1XP_016868668.1  t-SNARE domain-containing protein 1 isoform X13

  12. XM_011516921.1XP_011515223.1  t-SNARE domain-containing protein 1 isoform X15

    Conserved Domains (3) summary
    cd15877
    Location:416479
    SNARE_TSNARE1; SNARE motif of TSNARE1
    pfam13873
    Location:124198
    Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain
    pfam14523
    Location:265365
    Syntaxin_2; Syntaxin-like protein
  13. XM_011516919.1XP_011515221.1  t-SNARE domain-containing protein 1 isoform X9

    Related
    ENSP00000499343.1, ENST00000662555.1
    Conserved Domains (3) summary
    pfam13873
    Location:124198
    Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain
    pfam14523
    Location:265366
    Syntaxin_2; Syntaxin-like protein
    cl22856
    Location:417457
    SNARE; SNARE motif
  14. XM_017013175.1XP_016868664.1  t-SNARE domain-containing protein 1 isoform X7

  15. XM_011516922.1XP_011515224.1  t-SNARE domain-containing protein 1 isoform X16

    Conserved Domains (2) summary
    cl22856
    Location:417455
    SNARE; SNARE motif
    cl29093
    Location:258365
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
  16. XM_017013181.2XP_016868670.1  t-SNARE domain-containing protein 1 isoform X18

  17. XM_011516924.1XP_011515226.1  t-SNARE domain-containing protein 1 isoform X19

    Conserved Domains (2) summary
    pfam13873
    Location:124198
    Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain
    pfam14523
    Location:265298
    Syntaxin_2; Syntaxin-like protein

RNA

  1. XR_928309.1 RNA Sequence

  2. XR_928308.1 RNA Sequence

  3. XR_928307.2 RNA Sequence

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