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TSNARE1 t-SNARE domain containing 1 [ Homo sapiens (human) ]

Gene ID: 203062, updated on 22-Sep-2022

Summary

Official Symbol
TSNARE1provided by HGNC
Official Full Name
t-SNARE domain containing 1provided by HGNC
Primary source
HGNC:HGNC:26437
See related
Ensembl:ENSG00000171045 AllianceGenome:HGNC:26437
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in intracellular protein transport; vesicle docking; and vesicle fusion. Predicted to be located in membrane. Predicted to be part of SNARE complex. Predicted to be active in endomembrane system. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in skin (RPKM 3.2), ovary (RPKM 2.2) and 25 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See TSNARE1 in Genome Data Viewer
Location:
8q24.3
Exon count:
23
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (142212080..142407029, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (143351850..143544601, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (143293441..143484543, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375792 Neighboring gene Sharpr-MPRA regulatory region 1162 Neighboring gene long intergenic non-protein coding RNA 51 Neighboring gene RNA, 7SL, cytoplasmic 260, pseudogene Neighboring gene uncharacterized LOC124902075 Neighboring gene adhesion G protein-coupled receptor B1 Neighboring gene maestro heat like repeat family member 4, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31164, MGC142116

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
t-SNARE domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291931.2NP_001278860.1  t-SNARE domain-containing protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two consecutive in-frame exons in the 5' coding region, uses an alternate in-frame splice site in the central coding region, and also lacks two 3' exons but contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC103758, AI203371, BC065226, BF529741, BX115133, HY009343, HY264564
    Consensus CDS
    CCDS78369.1
    UniProtKB/TrEMBL
    E5RHT3, Q6P186
    Related
    ENSP00000429679.1, ENST00000519651.5
    Conserved Domains (2) summary
    pfam14523
    Location:46146
    Syntaxin_2; Syntaxin-like protein
    cl22856
    Location:197260
    SNARE; SNARE motif
  2. NM_001363740.2NP_001350669.1  t-SNARE domain-containing protein 1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC103758, AC134682, AK055726, BC126343
    Consensus CDS
    CCDS87630.1
    UniProtKB/TrEMBL
    E5RG83
    Related
    ENSP00000303437.4, ENST00000307180.4
    Conserved Domains (3) summary
    cd15877
    Location:417480
    SNARE_TSNARE1; SNARE motif of TSNARE1
    pfam13873
    Location:124201
    Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain
    pfam14523
    Location:265366
    Syntaxin_2; Syntaxin-like protein
  3. NM_001366901.1NP_001353830.1  t-SNARE domain-containing protein 1 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC103758, AC134682, BC143684
    Conserved Domains (3) summary
    cd15877
    Location:415478
    SNARE_TSNARE1; SNARE motif of TSNARE1
    pfam13873
    Location:124201
    Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain
    pfam14523
    Location:265365
    Syntaxin_2; Syntaxin-like protein
  4. NM_001366902.1NP_001353831.1  t-SNARE domain-containing protein 1 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC103758, AC129918, AC134682
    Conserved Domains (2) summary
    pfam13873
    Location:124201
    Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain
    pfam14523
    Location:265366
    Syntaxin_2; Syntaxin-like protein
  5. NM_001366903.1NP_001353832.1  t-SNARE domain-containing protein 1 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC103758, AC129918, AC134682
    Conserved Domains (2) summary
    pfam13873
    Location:124201
    Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain
    pfam14523
    Location:265365
    Syntaxin_2; Syntaxin-like protein
  6. NM_001366904.1NP_001353833.1  t-SNARE domain-containing protein 1 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC103758, AC129918, AC134682, KC877361
    Conserved Domains (3) summary
    cd15877
    Location:416479
    SNARE_TSNARE1; SNARE motif of TSNARE1
    pfam13873
    Location:124201
    Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain
    pfam14523
    Location:265366
    Syntaxin_2; Syntaxin-like protein
  7. NM_145003.5NP_659440.2  t-SNARE domain-containing protein 1 isoform a

    See identical proteins and their annotated locations for NP_659440.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (a).
    Source sequence(s)
    AC103758, AK055726, BC113556, HY009343
    Consensus CDS
    CCDS6384.1
    UniProtKB/Swiss-Prot
    Q14D03, Q96NA8
    Related
    ENSP00000428763.2, ENST00000524325.6
    Conserved Domains (3) summary
    cd15877
    Location:416479
    SNARE_TSNARE1; SNARE motif of TSNARE1
    pfam13873
    Location:124201
    Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain
    pfam14523
    Location:265366
    Syntaxin_2; Syntaxin-like protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    142212080..142407029 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421491.1XP_047277447.1  t-SNARE domain-containing protein 1 isoform X37

  2. XM_047421483.1XP_047277439.1  t-SNARE domain-containing protein 1 isoform X28

  3. XM_047421488.1XP_047277444.1  t-SNARE domain-containing protein 1 isoform X35

  4. XM_047421487.1XP_047277443.1  t-SNARE domain-containing protein 1 isoform X34

  5. XM_047421484.1XP_047277440.1  t-SNARE domain-containing protein 1 isoform X29

  6. XM_047421486.1XP_047277442.1  t-SNARE domain-containing protein 1 isoform X33

  7. XM_047421485.1XP_047277441.1  t-SNARE domain-containing protein 1 isoform X32

  8. XM_011516912.3XP_011515214.1  t-SNARE domain-containing protein 1 isoform X5

    Conserved Domains (3) summary
    pfam13873
    Location:124198
    Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain
    pfam14523
    Location:265366
    Syntaxin_2; Syntaxin-like protein
    cl22856
    Location:416456
    SNARE; SNARE motif
  9. XM_047421473.1XP_047277429.1  t-SNARE domain-containing protein 1 isoform X18

  10. XM_017013179.2XP_016868668.1  t-SNARE domain-containing protein 1 isoform X31

  11. XM_047421480.1XP_047277436.1  t-SNARE domain-containing protein 1 isoform X25

  12. XM_047421475.1XP_047277431.1  t-SNARE domain-containing protein 1 isoform X20

  13. XM_047421476.1XP_047277432.1  t-SNARE domain-containing protein 1 isoform X21

  14. XM_047421481.1XP_047277437.1  t-SNARE domain-containing protein 1 isoform X26

  15. XM_011516921.2XP_011515223.1  t-SNARE domain-containing protein 1 isoform X30

    Conserved Domains (3) summary
    cd15877
    Location:416479
    SNARE_TSNARE1; SNARE motif of TSNARE1
    pfam13873
    Location:124198
    Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain
    pfam14523
    Location:265365
    Syntaxin_2; Syntaxin-like protein
  16. XM_047421482.1XP_047277438.1  t-SNARE domain-containing protein 1 isoform X27

  17. XM_047421459.1XP_047277415.1  t-SNARE domain-containing protein 1 isoform X3

  18. XM_047421472.1XP_047277428.1  t-SNARE domain-containing protein 1 isoform X17

  19. XM_047421466.1XP_047277422.1  t-SNARE domain-containing protein 1 isoform X11

  20. XM_047421474.1XP_047277430.1  t-SNARE domain-containing protein 1 isoform X19

    Related
    ENSP00000499343.1, ENST00000662555.1
  21. XM_047421461.1XP_047277417.1  t-SNARE domain-containing protein 1 isoform X6

  22. XM_047421471.1XP_047277427.1  t-SNARE domain-containing protein 1 isoform X16

  23. XM_047421462.1XP_047277418.1  t-SNARE domain-containing protein 1 isoform X7

  24. XM_047421479.1XP_047277435.1  t-SNARE domain-containing protein 1 isoform X24

  25. XM_047421478.1XP_047277434.1  t-SNARE domain-containing protein 1 isoform X23

  26. XM_047421477.1XP_047277433.1  t-SNARE domain-containing protein 1 isoform X22

  27. XM_047421470.1XP_047277426.1  t-SNARE domain-containing protein 1 isoform X15

  28. XM_047421469.1XP_047277425.1  t-SNARE domain-containing protein 1 isoform X14

  29. XM_047421468.1XP_047277424.1  t-SNARE domain-containing protein 1 isoform X13

  30. XM_047421460.1XP_047277416.1  t-SNARE domain-containing protein 1 isoform X4

  31. XM_047421465.1XP_047277421.1  t-SNARE domain-containing protein 1 isoform X10

  32. XM_047421464.1XP_047277420.1  t-SNARE domain-containing protein 1 isoform X9

  33. XM_047421457.1XP_047277413.1  t-SNARE domain-containing protein 1 isoform X1

  34. XM_047421463.1XP_047277419.1  t-SNARE domain-containing protein 1 isoform X8

  35. XM_047421458.1XP_047277414.1  t-SNARE domain-containing protein 1 isoform X2

  36. XM_047421467.1XP_047277423.1  t-SNARE domain-containing protein 1 isoform X12

  37. XM_047421490.1XP_047277446.1  t-SNARE domain-containing protein 1 isoform X36

  38. XM_047421489.1XP_047277445.1  t-SNARE domain-containing protein 1 isoform X36

  39. XM_011516924.2XP_011515226.1  t-SNARE domain-containing protein 1 isoform X38

    Conserved Domains (2) summary
    pfam13873
    Location:124198
    Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain
    pfam14523
    Location:265298
    Syntaxin_2; Syntaxin-like protein

RNA

  1. XR_007060718.1 RNA Sequence

  2. XR_007060717.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    143351850..143544601 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)