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ADCK5 aarF domain containing kinase 5 [ Homo sapiens (human) ]

Gene ID: 203054, updated on 22-Sep-2022

Summary

Official Symbol
ADCK5provided by HGNC
Official Full Name
aarF domain containing kinase 5provided by HGNC
Primary source
HGNC:HGNC:21738
See related
Ensembl:ENSG00000173137 AllianceGenome:HGNC:21738
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum (RPKM 5.3), small intestine (RPKM 4.4) and 25 other tissues See more
Orthologs
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Genomic context

See ADCK5 in Genome Data Viewer
Location:
8q24.3
Exon count:
19
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (144373088..144393242)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (145542698..145562879)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145597736..145618457)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 52 member 2 Neighboring gene uncharacterized LOC101928902 Neighboring gene cleavage and polyadenylation specific factor 1 Neighboring gene microRNA 939 Neighboring gene microRNA 1234

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35454, MGC126708

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
uncharacterized aarF domain-containing protein kinase 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174922.5NP_777582.4  uncharacterized aarF domain-containing protein kinase 5

    See identical proteins and their annotated locations for NP_777582.4

    Status: VALIDATED

    Source sequence(s)
    BC064345, BC101659, HY037845
    Consensus CDS
    CCDS34965.2
    UniProtKB/Swiss-Prot
    Q3MIX3, Q8N5V3
    Related
    ENSP00000310547.6, ENST00000308860.11
    Conserved Domains (1) summary
    cd13969
    Location:169409
    ADCK1-like; aarF domain containing kinase 1 and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    144373088..144393242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013174.2XP_016868663.1  uncharacterized aarF domain-containing protein kinase 5 isoform X2

    Conserved Domains (2) summary
    COG0661
    Location:61341
    AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
    cd13969
    Location:102342
    ADCK1-like; aarF domain containing kinase 1 and similar proteins
  2. XM_011516907.4XP_011515209.1  uncharacterized aarF domain-containing protein kinase 5 isoform X1

    Conserved Domains (2) summary
    COG0661
    Location:202482
    AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
    cd13969
    Location:243483
    ADCK1-like; aarF domain containing kinase 1 and similar proteins
  3. XM_047421456.1XP_047277412.1  uncharacterized aarF domain-containing protein kinase 5 isoform X3

  4. XM_011516909.2XP_011515211.1  uncharacterized aarF domain-containing protein kinase 5 isoform X2

    See identical proteins and their annotated locations for XP_011515211.1

    Conserved Domains (2) summary
    COG0661
    Location:61341
    AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
    cd13969
    Location:102342
    ADCK1-like; aarF domain containing kinase 1 and similar proteins
  5. XM_011516910.2XP_011515212.1  uncharacterized aarF domain-containing protein kinase 5 isoform X4

    See identical proteins and their annotated locations for XP_011515212.1

    Conserved Domains (2) summary
    COG0661
    Location:6301
    AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
    cd13969
    Location:62302
    ADCK1-like; aarF domain containing kinase 1 and similar proteins
  6. XM_006716527.3XP_006716590.1  uncharacterized aarF domain-containing protein kinase 5 isoform X4

    See identical proteins and their annotated locations for XP_006716590.1

    Conserved Domains (2) summary
    COG0661
    Location:6301
    AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
    cd13969
    Location:62302
    ADCK1-like; aarF domain containing kinase 1 and similar proteins

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654716.1 Reference GRCh38.p14 PATCHES

    Range
    104650..123845
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    145542698..145562879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)