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ENO2 enolase 2 [ Homo sapiens (human) ]

Gene ID: 2026, updated on 11-Jun-2021

Summary

Official Symbol
ENO2provided by HGNC
Official Full Name
enolase 2provided by HGNC
Primary source
HGNC:HGNC:3353
See related
Ensembl:ENSG00000111674 MIM:131360
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NSE; HEL-S-279
Summary
This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 167.6), adrenal (RPKM 26.3) and 9 other tissues See more
Orthologs
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Genomic context

See ENO2 in Genome Data Viewer
Location:
12p13.31
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (6914580..6923697)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (7023744..7032860)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369632 Neighboring gene DSTN pseudogene 2 Neighboring gene leucine rich repeat containing 23 Neighboring gene atrophin 1 Neighboring gene atrophin 1 repeat instability region Neighboring gene chromosome 12 open reading frame 57 Neighboring gene RNA, U7 small nuclear 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphopyruvate hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphopyruvate hydratase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in canonical glycolysis TAS
Traceable Author Statement
more info
 
involved_in gluconeogenesis TAS
Traceable Author Statement
more info
 
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glycolytic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in regulation of vacuole fusion, non-autophagic IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in extracellular space HDA PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 
part_of phosphopyruvate hydratase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in photoreceptor inner segment IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
gamma-enolase
Names
2-phospho-D-glycerate hydro-lyase
2-phospho-D-glycerate hydrolyase
enolase 2 (gamma, neuronal)
epididymis secretory protein Li 279
neural enolase
neuron specific gamma enolase
neuron-specific enolase
neuronal enriched enolase
neurone-specific enolase
NP_001966.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001975.3NP_001966.1  gamma-enolase

    See identical proteins and their annotated locations for NP_001966.1

    Status: REVIEWED

    Source sequence(s)
    U47924
    Consensus CDS
    CCDS8570.1
    UniProtKB/Swiss-Prot
    P09104
    UniProtKB/TrEMBL
    Q6FHV6
    Related
    ENSP00000229277.1, ENST00000229277.6
    Conserved Domains (1) summary
    PLN00191
    Location:2432
    PLN00191; enolase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    6914580..6923697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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