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Atxn2 ataxin 2 [ Mus musculus (house mouse) ]

Gene ID: 20239, updated on 6-Jun-2024

Summary

Official Symbol
Atxn2provided by MGI
Official Full Name
ataxin 2provided by MGI
Primary source
MGI:MGI:1277223
See related
Ensembl:ENSMUSG00000042605 AllianceGenome:MGI:1277223
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ATX2; Sca2; 9630045M23Rik
Summary
Predicted to enable RNA binding activity; epidermal growth factor receptor binding activity; and protein C-terminus binding activity. Acts upstream of or within several processes, including homeostasis of number of cells; neuromuscular process; and neuron differentiation. Located in perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; liver; sensory organ; and spleen. Used to study spinocerebellar ataxia type 2. Human ortholog(s) of this gene implicated in late onset Parkinson's disease and spinocerebellar ataxia type 2. Orthologous to human ATXN2 (ataxin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 15.1), testis adult (RPKM 13.0) and 28 other tissues See more
Orthologs
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Genomic context

See Atxn2 in Genome Data Viewer
Location:
5 F; 5 61.93 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (121849794..121954372)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (121711609..121814950)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14261 Neighboring gene acyl-Coenzyme A dehydrogenase family, member 12 Neighboring gene acyl-Coenzyme A dehydrogenase family, member 10 Neighboring gene BRCA1 associated protein Neighboring gene STARR-seq mESC enhancer starr_14264 Neighboring gene microRNA 7031 Neighboring gene SH2B adaptor protein 3 Neighboring gene predicted gene, 32422

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (6)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables DNA binding domain binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables epidermal growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ataxin-2
Names
spinocerebellar ataxia 2 (olivopontocerebellar ataxia 2, autosomal dominant, ataxin 2)
spinocerebellar ataxia 2 homolog
spinocerebellar ataxia type 2 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359153.2NP_001346082.1  ataxin-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113302, AC116104
    UniProtKB/TrEMBL
    Q3UX07
    Conserved Domains (5) summary
    pfam06741
    Location:141202
    LsmAD; LsmAD domain
    pfam14438
    Location:174
    SM-ATX; Ataxin 2 SM domain
    cl26386
    Location:267436
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    cl26464
    Location:593911
    Atrophin-1; Atrophin-1 family
    cl28087
    Location:524654
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
  2. NM_009125.3NP_033151.3  ataxin-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC113302, AC116104
    Consensus CDS
    CCDS39250.1
    UniProtKB/TrEMBL
    E9QM77
    Related
    ENSMUSP00000056715.8, ENSMUST00000051950.14

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    121849794..121954372
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254244.2XP_030110104.1  ataxin-2 isoform X12

    UniProtKB/TrEMBL
    E9QM77
    Conserved Domains (6) summary
    PHA03247
    Location:680998
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK07003
    Location:354523
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam07145
    Location:661676
    PAM2; Ataxin-2 C-terminal region
    pfam06741
    Location:228289
    LsmAD; LsmAD domain
    pfam14438
    Location:85161
    SM-ATX; Ataxin 2 SM domain
  2. XM_030254262.1XP_030110122.1  ataxin-2 isoform X31

    UniProtKB/TrEMBL
    E9QM77
    Conserved Domains (6) summary
    PHA03247
    Location:680998
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK07003
    Location:354523
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam07145
    Location:661676
    PAM2; Ataxin-2 C-terminal region
    pfam06741
    Location:228289
    LsmAD; LsmAD domain
    pfam14438
    Location:85161
    SM-ATX; Ataxin 2 SM domain
  3. XM_030254265.2XP_030110125.1  ataxin-2 isoform X34

    UniProtKB/TrEMBL
    F6U2C2
    Conserved Domains (6) summary
    PHA03247
    Location:680998
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK07003
    Location:354523
    PRK07003; DNA polymerase III subunit gamma/tau
    PRK10263
    Location:611741
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:228289
    LsmAD; LsmAD domain
    pfam14438
    Location:85161
    SM-ATX; Ataxin 2 SM domain
  4. XM_030254263.2XP_030110123.1  ataxin-2 isoform X32

    UniProtKB/TrEMBL
    E9QM77
    Conserved Domains (6) summary
    PHA03247
    Location:386992
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam03154
    Location:7431116
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:228289
    LsmAD; LsmAD domain
    pfam09770
    Location:751923
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:85161
    SM-ATX; Ataxin 2 SM domain
  5. XM_030254234.2XP_030110094.1  ataxin-2 isoform X1

    UniProtKB/TrEMBL
    E9QM77
    Conserved Domains (6) summary
    PHA03247
    Location:7621080
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK12323
    Location:399606
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam07145
    Location:743758
    PAM2; Ataxin-2 C-terminal region
    pfam06741
    Location:228289
    LsmAD; LsmAD domain
    pfam14438
    Location:85161
    SM-ATX; Ataxin 2 SM domain
  6. XM_030254251.2XP_030110111.1  ataxin-2 isoform X18

    UniProtKB/TrEMBL
    F6U2C2
    Conserved Domains (6) summary
    PHA03247
    Location:7621080
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:693823
    PRK10263; DNA translocase FtsK; Provisional
    PRK12323
    Location:399606
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam06741
    Location:228289
    LsmAD; LsmAD domain
    pfam14438
    Location:85161
    SM-ATX; Ataxin 2 SM domain
  7. XM_030254235.2XP_030110095.1  ataxin-2 isoform X2

    UniProtKB/TrEMBL
    E9QM77
    Conserved Domains (6) summary
    COG5180
    Location:174318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK12323
    Location:399606
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam07145
    Location:743758
    PAM2; Ataxin-2 C-terminal region
    pfam03154
    Location:7551142
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:228289
    LsmAD; LsmAD domain
    pfam14438
    Location:85161
    SM-ATX; Ataxin 2 SM domain
  8. XM_030254240.2XP_030110100.1  ataxin-2 isoform X8

    UniProtKB/TrEMBL
    E9QM77
    Conserved Domains (6) summary
    PHA03247
    Location:7011019
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam07145
    Location:682697
    PAM2; Ataxin-2 C-terminal region
    pfam06741
    Location:228289
    LsmAD; LsmAD domain
    pfam11489
    Location:452761
    Aim21; Altered inheritance of mitochondria protein 21
    pfam14438
    Location:85161
    SM-ATX; Ataxin 2 SM domain
  9. XM_030254242.2XP_030110102.1  ataxin-2 isoform X10

    UniProtKB/TrEMBL
    E9QM77
    Conserved Domains (5) summary
    PHA03247
    Location:6891007
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam07145
    Location:670685
    PAM2; Ataxin-2 C-terminal region
    pfam06741
    Location:228289
    LsmAD; LsmAD domain
    pfam14438
    Location:85161
    SM-ATX; Ataxin 2 SM domain
  10. XM_030254243.1XP_030110103.1  ataxin-2 isoform X11

    UniProtKB/TrEMBL
    E9QM77
    Conserved Domains (5) summary
    COG5180
    Location:174318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK12323
    Location:399606
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam06741
    Location:228289
    LsmAD; LsmAD domain
    pfam09770
    Location:7401009
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:85161
    SM-ATX; Ataxin 2 SM domain
  11. XM_030254258.2XP_030110118.1  ataxin-2 isoform X27

    UniProtKB/TrEMBL
    F6U2C2
    Conserved Domains (5) summary
    PHA03247
    Location:4831062
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam06741
    Location:228289
    LsmAD; LsmAD domain
    pfam09770
    Location:7401009
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:85161
    SM-ATX; Ataxin 2 SM domain
  12. XM_030254241.2XP_030110101.1  ataxin-2 isoform X9

    UniProtKB/TrEMBL
    E9QM77
    Conserved Domains (6) summary
    COG5180
    Location:174318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK12323
    Location:399606
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam07145
    Location:743758
    PAM2; Ataxin-2 C-terminal region
    pfam03154
    Location:7551138
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:228289
    LsmAD; LsmAD domain
    pfam14438
    Location:85161
    SM-ATX; Ataxin 2 SM domain
  13. XM_030254252.2XP_030110112.1  ataxin-2 isoform X20

    UniProtKB/TrEMBL
    F6U2C2
    Conserved Domains (6) summary
    COG5180
    Location:174318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK12323
    Location:399606
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam03154
    Location:6911067
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:228289
    LsmAD; LsmAD domain
    pfam09770
    Location:763935
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:85161
    SM-ATX; Ataxin 2 SM domain
  14. XM_030254245.1XP_030110105.1  ataxin-2 isoform X13

    UniProtKB/TrEMBL
    E9QM77
    Conserved Domains (6) summary
    COG5180
    Location:174318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK12323
    Location:399606
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam07145
    Location:743758
    PAM2; Ataxin-2 C-terminal region
    pfam03154
    Location:7551120
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:228289
    LsmAD; LsmAD domain
    pfam14438
    Location:85161
    SM-ATX; Ataxin 2 SM domain
  15. XM_030254259.1XP_030110119.1  ataxin-2 isoform X28

    UniProtKB/TrEMBL
    F6U2C2
    Conserved Domains (6) summary
    PHA03247
    Location:485940
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:8991066
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:228289
    LsmAD; LsmAD domain
    pfam09770
    Location:763951
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:85161
    SM-ATX; Ataxin 2 SM domain
  16. XM_017320749.2XP_017176238.1  ataxin-2 isoform X19

    UniProtKB/TrEMBL
    E9QM77
    Conserved Domains (5) summary
    PHA03247
    Location:386928
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam03154
    Location:7431098
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:228289
    LsmAD; LsmAD domain
    pfam14438
    Location:85161
    SM-ATX; Ataxin 2 SM domain
  17. XM_030254261.1XP_030110121.1  ataxin-2 isoform X30

    UniProtKB/TrEMBL
    F6U2C2
    Conserved Domains (6) summary
    PHA03247
    Location:473928
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:8871054
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:228289
    LsmAD; LsmAD domain
    pfam09770
    Location:751939
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:85161
    SM-ATX; Ataxin 2 SM domain
  18. XM_030254236.1XP_030110096.1  ataxin-2 isoform X4

    UniProtKB/TrEMBL
    E9QM77
    Conserved Domains (6) summary
    COG5180
    Location:174318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK12323
    Location:399606
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam07145
    Location:743758
    PAM2; Ataxin-2 C-terminal region
    pfam03154
    Location:7551126
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:228289
    LsmAD; LsmAD domain
    pfam14438
    Location:85161
    SM-ATX; Ataxin 2 SM domain
  19. XM_030254237.1XP_030110097.1  ataxin-2 isoform X5

    UniProtKB/TrEMBL
    E9QM77
    Conserved Domains (6) summary
    COG5180
    Location:174318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK12323
    Location:399606
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam07145
    Location:743758
    PAM2; Ataxin-2 C-terminal region
    pfam03154
    Location:7551124
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:228289
    LsmAD; LsmAD domain
    pfam14438
    Location:85161
    SM-ATX; Ataxin 2 SM domain
  20. XM_030254239.1XP_030110099.1  ataxin-2 isoform X7

    UniProtKB/TrEMBL
    E9QM77
    Conserved Domains (5) summary
    PHA03247
    Location:386928
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam03154
    Location:7431112
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:228289
    LsmAD; LsmAD domain
    pfam14438
    Location:85161
    SM-ATX; Ataxin 2 SM domain
  21. XM_030254249.1XP_030110109.1  ataxin-2 isoform X16

    UniProtKB/TrEMBL
    E9QM77
    Conserved Domains (5) summary
    PHA03247
    Location:439869
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam03154
    Location:6821053
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:228289
    LsmAD; LsmAD domain
    pfam14438
    Location:85161
    SM-ATX; Ataxin 2 SM domain
  22. XM_017320748.3XP_017176237.1  ataxin-2 isoform X3

    UniProtKB/TrEMBL
    E9QM77
    Conserved Domains (5) summary
    PHA03247
    Location:386992
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam03154
    Location:7431130
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:228289
    LsmAD; LsmAD domain
    pfam14438
    Location:85161
    SM-ATX; Ataxin 2 SM domain
  23. XM_030254246.2XP_030110106.1  ataxin-2 isoform X14

    UniProtKB/TrEMBL
    E9QM77
    Conserved Domains (6) summary
    COG5180
    Location:174318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK07003
    Location:354523
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam07145
    Location:661676
    PAM2; Ataxin-2 C-terminal region
    pfam03154
    Location:6731060
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:228289
    LsmAD; LsmAD domain
    pfam14438
    Location:85161
    SM-ATX; Ataxin 2 SM domain
  24. XM_036164934.1XP_036020827.1  ataxin-2 isoform X25

    UniProtKB/TrEMBL
    F6U2C2
    Conserved Domains (6) summary
    PHA03247
    Location:7501068
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:681811
    PRK10263; DNA translocase FtsK; Provisional
    PRK12323
    Location:387569
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam06741
    Location:228289
    LsmAD; LsmAD domain
    pfam14438
    Location:88161
    SM-ATX; Ataxin 2 SM domain
  25. XM_030254250.2XP_030110110.1  ataxin-2 isoform X17

    UniProtKB/TrEMBL
    E9QM77
    Conserved Domains (5) summary
    PHA03247
    Location:3861022
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam06741
    Location:228289
    LsmAD; LsmAD domain
    pfam09770
    Location:728997
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:85161
    SM-ATX; Ataxin 2 SM domain
  26. XM_030254260.2XP_030110120.1  ataxin-2 isoform X29

    UniProtKB/TrEMBL
    F6U2C2
    Related
    ENSMUSP00000124070.2, ENSMUST00000161064.8
    Conserved Domains (5) summary
    PHA03247
    Location:473930
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam06741
    Location:228289
    LsmAD; LsmAD domain
    pfam09770
    Location:728997
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:85161
    SM-ATX; Ataxin 2 SM domain
  27. XM_017320750.3XP_017176239.1  ataxin-2 isoform X26

    UniProtKB/TrEMBL
    F6U2C2
    Conserved Domains (5) summary
    PHA03247
    Location:386992
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam06741
    Location:228289
    LsmAD; LsmAD domain
    pfam09770
    Location:751923
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:85161
    SM-ATX; Ataxin 2 SM domain
  28. XM_030254266.2XP_030110126.1  ataxin-2 isoform X35

    UniProtKB/TrEMBL
    F6U2C2
    Conserved Domains (6) summary
    COG5180
    Location:174318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK07003
    Location:354523
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam03154
    Location:609985
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:228289
    LsmAD; LsmAD domain
    pfam09770
    Location:681853
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:85161
    SM-ATX; Ataxin 2 SM domain
  29. XM_030254238.2XP_030110098.1  ataxin-2 isoform X6

    UniProtKB/TrEMBL
    E9QM77
    Conserved Domains (5) summary
    PHA03247
    Location:3861022
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam06741
    Location:228289
    LsmAD; LsmAD domain
    pfam09770
    Location:728997
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:85161
    SM-ATX; Ataxin 2 SM domain
  30. XM_030254255.2XP_030110115.1  ataxin-2 isoform X22

    UniProtKB/TrEMBL
    E9QM77
    Conserved Domains (6) summary
    COG5180
    Location:174318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK07003
    Location:354523
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam07145
    Location:661676
    PAM2; Ataxin-2 C-terminal region
    pfam03154
    Location:6731044
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:228289
    LsmAD; LsmAD domain
    pfam14438
    Location:85161
    SM-ATX; Ataxin 2 SM domain
  31. XM_030254257.2XP_030110117.1  ataxin-2 isoform X24

    UniProtKB/TrEMBL
    E9QM77
    Conserved Domains (6) summary
    COG5180
    Location:174318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK07003
    Location:354523
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam07145
    Location:661676
    PAM2; Ataxin-2 C-terminal region
    pfam03154
    Location:6731042
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:228289
    LsmAD; LsmAD domain
    pfam14438
    Location:85161
    SM-ATX; Ataxin 2 SM domain
  32. XM_030254247.2XP_030110107.1  ataxin-2 isoform X15

    UniProtKB/TrEMBL
    Q3UX07
    Conserved Domains (6) summary
    PHA03247
    Location:675993
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:87231
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK12323
    Location:312519
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam07145
    Location:656671
    PAM2; Ataxin-2 C-terminal region
    pfam06741
    Location:141202
    LsmAD; LsmAD domain
    pfam14438
    Location:174
    SM-ATX; Ataxin 2 SM domain
  33. XM_030254253.2XP_030110113.1  ataxin-2 isoform X21

    UniProtKB/TrEMBL
    Q3UX07
    Conserved Domains (6) summary
    PHA03247
    Location:663981
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:87231
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK12323
    Location:300482
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam06741
    Location:141202
    LsmAD; LsmAD domain
    pfam07145
    Location:645659
    PAM2; Ataxin-2 C-terminal region
    pfam14438
    Location:174
    SM-ATX; Ataxin 2 SM domain
  34. XM_030254256.2XP_030110116.1  ataxin-2 isoform X23

    UniProtKB/TrEMBL
    Q3UX07
    Conserved Domains (5) summary
    PHA03247
    Location:299905
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:87231
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam03154
    Location:6561043
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:141202
    LsmAD; LsmAD domain
    pfam14438
    Location:174
    SM-ATX; Ataxin 2 SM domain
  35. XM_030254264.2XP_030110124.1  ataxin-2 isoform X33

    UniProtKB/TrEMBL
    Q3UX07
    Conserved Domains (6) summary
    PHA03247
    Location:593911
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:87231
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK07003
    Location:267436
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam07145
    Location:574589
    PAM2; Ataxin-2 C-terminal region
    pfam06741
    Location:141202
    LsmAD; LsmAD domain
    pfam14438
    Location:174
    SM-ATX; Ataxin 2 SM domain
  36. XM_036164933.1XP_036020826.1  ataxin-2 isoform X21

    UniProtKB/TrEMBL
    Q3UX07
    Conserved Domains (6) summary
    PHA03247
    Location:663981
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:87231
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK12323
    Location:300482
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam06741
    Location:141202
    LsmAD; LsmAD domain
    pfam07145
    Location:645659
    PAM2; Ataxin-2 C-terminal region
    pfam14438
    Location:174
    SM-ATX; Ataxin 2 SM domain
  37. XM_006530228.4XP_006530291.1  ataxin-2 isoform X15

    UniProtKB/TrEMBL
    Q3UX07
    Conserved Domains (6) summary
    PHA03247
    Location:675993
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:87231
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK12323
    Location:312519
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam07145
    Location:656671
    PAM2; Ataxin-2 C-terminal region
    pfam06741
    Location:141202
    LsmAD; LsmAD domain
    pfam14438
    Location:174
    SM-ATX; Ataxin 2 SM domain
  38. XM_030254248.2XP_030110108.1  ataxin-2 isoform X15

    UniProtKB/TrEMBL
    Q3UX07
    Conserved Domains (6) summary
    PHA03247
    Location:675993
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:87231
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK12323
    Location:312519
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam07145
    Location:656671
    PAM2; Ataxin-2 C-terminal region
    pfam06741
    Location:141202
    LsmAD; LsmAD domain
    pfam14438
    Location:174
    SM-ATX; Ataxin 2 SM domain
  39. XM_030254254.2XP_030110114.1  ataxin-2 isoform X21

    UniProtKB/TrEMBL
    Q3UX07
    Conserved Domains (6) summary
    PHA03247
    Location:663981
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:87231
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK12323
    Location:300482
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam06741
    Location:141202
    LsmAD; LsmAD domain
    pfam07145
    Location:645659
    PAM2; Ataxin-2 C-terminal region
    pfam14438
    Location:174
    SM-ATX; Ataxin 2 SM domain

RNA

  1. XR_003955602.2 RNA Sequence