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Atxn2 ataxin 2 [ Mus musculus (house mouse) ]

Gene ID: 20239, updated on 9-Mar-2023

Summary

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Official Symbol
Atxn2provided by MGI
Official Full Name
ataxin 2provided by MGI
Primary source
MGI:MGI:1277223
See related
Ensembl:ENSMUSG00000042605 AllianceGenome:MGI:1277223
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ATX2; Sca2; 9630045M23Rik
Summary
Predicted to enable RNA binding activity; epidermal growth factor receptor binding activity; and protein C-terminus binding activity. Acts upstream of or within several processes, including homeostasis of number of cells; neuromuscular process; and neuron differentiation. Located in perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; liver; sensory organ; and spleen. Used to study spinocerebellar ataxia type 2. Human ortholog(s) of this gene implicated in late onset Parkinson's disease and spinocerebellar ataxia type 2. Orthologous to human ATXN2 (ataxin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 15.1), testis adult (RPKM 13.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Atxn2 in Genome Data Viewer
Location:
5; 5 F
Exon count:
26
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (121849672..121954372)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (121711609..121814950)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene acyl-Coenzyme A dehydrogenase family, member 12 Neighboring gene acyl-Coenzyme A dehydrogenase family, member 10 Neighboring gene BRCA1 associated protein Neighboring gene microRNA 7031 Neighboring gene SH2B adaptor protein 3 Neighboring gene predicted gene, 32422

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Intracellular dynamics of Ataxin-2 in the human brains with normal and frontotemporal lobar degeneration with TDP-43 inclusions.
    Title: Intracellular dynamics of Ataxin-2 in the human brains with normal and frontotemporal lobar degeneration with TDP-43 inclusions.
  2. ALS-associated genes in SCA2 mouse spinal cord transcriptomes.
    Title: ALS-associated genes in SCA2 mouse spinal cord transcriptomes.
  3. Mouse Ataxin-2 Expansion Downregulates CamKII and Other Calcium Signaling Factors, Impairing Granule-Purkinje Neuron Synaptic Strength.
    Title: Mouse Ataxin-2 Expansion Downregulates CamKII and Other Calcium Signaling Factors, Impairing Granule-Purkinje Neuron Synaptic Strength.
  4. The RNA-Binding Protein ATXN2 is Expressed during Megakaryopoiesis and May Control Timing of Gene Expression.
    Title: The RNA-Binding Protein ATXN2 is Expressed during Megakaryopoiesis and May Control Timing of Gene Expression.
  5. An Atxn2-CAG100-knock-in mouse model of SCA2 was generated with intact ATXN2 expression regulation.
    Title: Generation of an Atxn2-CAG100 knock-in mouse reveals N-acetylaspartate production deficit due to early Nat8l dysregulation.
  6. Ataxin-2 knockout mice exhibit progressive obesity, dyslipidemia, and insulin resistance.
    Title: In Human and Mouse Spino-Cerebellar Tissue, Ataxin-2 Expansion Affects Ceramide-Sphingomyelin Metabolism.
  7. Atxn2(-/-) mice showed an unstable rhythmicity of locomotor activity, but the level of PER1 and PER2 IR in the SCN did not differ between genotypes.
    Title: Impact of Ataxin-2 knock out on circadian locomotor behavior and PER immunoreaction in the SCN of mice.
  8. Findings provide evidence that the physiological functions and protein interactions of ATXN2 are relevant for calcium-mediated excitation of Purkinje cells as well as for ATXN2-triggered neurotoxicity.
    Title: Atxn2 Knockout and CAG42-Knock-in Cerebellum Shows Similarly Dysregulated Expression in Calcium Homeostasis Pathway.
  9. Results from global proteome and metabolome profiling of Atxn2-KO mouse liver and cerebellum indicates that ATXN2 modulates nutrition and basal metabolism.
    Title: Ataxin-2 (Atxn2)-Knock-Out Mice Show Branched Chain Amino Acids and Fatty Acids Pathway Alterations.
  10. work suggests that in Machado-Joseph disease, mutant ataxin-3 drives an abnormal reduction of ataxin-2 levels, which overactivates poly(A)-binding protein, increases translation of mutant ataxin-3 and other proteins and aggravates Machado-Joseph disease.
    Title: Re-establishing ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables DNA binding domain binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables epidermal growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
involved_in P-body assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cerebellar Purkinje cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within homeostasis of number of cells IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuromuscular process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuron projection morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in stress granule assembly IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in stress granule assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of polysome ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ataxin-2
Names
spinocerebellar ataxia 2 (olivopontocerebellar ataxia 2, autosomal dominant, ataxin 2)
spinocerebellar ataxia 2 homolog
spinocerebellar ataxia type 2 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359153.1 → NP_001346082.1  ataxin-2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AC113302, AC116104
    Conserved Domains (5) summary
    pfam06741
    Location:141 → 202
    LsmAD; LsmAD domain
    pfam14438
    Location:1 → 74
    SM-ATX; Ataxin 2 SM domain
    cl26386
    Location:267 → 436
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    cl26464
    Location:593 → 911
    Atrophin-1; Atrophin-1 family
    cl28087
    Location:524 → 654
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

  2. NM_009125.2 → NP_033151.2  ataxin-2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AA178023, AC116104, AF041472, AK135976
    Consensus CDS
    CCDS39250.1
    UniProtKB/Swiss-Prot
    O70305
    UniProtKB/TrEMBL
    E9QM77, Q3UX07
    Related
    ENSMUSP00000056715.8, ENSMUST00000051950.14
    Conserved Domains (3) summary
    pfam06741
    Location:378 → 439
    LsmAD; LsmAD domain
    pfam07145
    Location:880 → 896
    PAM2; Ataxin-2 C-terminal region
    pfam14438
    Location:237 → 306
    SM-ATX; Ataxin 2 SM domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    121849672..121954372
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254244.2 → XP_030110104.1  ataxin-2 isoform X12

    Conserved Domains (6) summary
    PHA03247
    Location:680 → 998
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174 → 318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK07003
    Location:354 → 523
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam07145
    Location:661 → 676
    PAM2; Ataxin-2 C-terminal region
    pfam06741
    Location:228 → 289
    LsmAD; LsmAD domain
    pfam14438
    Location:85 → 161
    SM-ATX; Ataxin 2 SM domain

  2. XM_030254262.1 → XP_030110122.1  ataxin-2 isoform X31

    Conserved Domains (6) summary
    PHA03247
    Location:680 → 998
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174 → 318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK07003
    Location:354 → 523
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam07145
    Location:661 → 676
    PAM2; Ataxin-2 C-terminal region
    pfam06741
    Location:228 → 289
    LsmAD; LsmAD domain
    pfam14438
    Location:85 → 161
    SM-ATX; Ataxin 2 SM domain

  3. XM_030254265.2 → XP_030110125.1  ataxin-2 isoform X34

    Conserved Domains (6) summary
    PHA03247
    Location:680 → 998
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174 → 318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK07003
    Location:354 → 523
    PRK07003; DNA polymerase III subunit gamma/tau
    PRK10263
    Location:611 → 741
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:228 → 289
    LsmAD; LsmAD domain
    pfam14438
    Location:85 → 161
    SM-ATX; Ataxin 2 SM domain

  4. XM_030254263.2 → XP_030110123.1  ataxin-2 isoform X32

    Conserved Domains (6) summary
    PHA03247
    Location:386 → 992
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174 → 318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam03154
    Location:743 → 1116
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:228 → 289
    LsmAD; LsmAD domain
    pfam09770
    Location:751 → 923
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:85 → 161
    SM-ATX; Ataxin 2 SM domain

  5. XM_030254234.2 → XP_030110094.1  ataxin-2 isoform X1

    Conserved Domains (6) summary
    PHA03247
    Location:762 → 1080
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174 → 318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK12323
    Location:399 → 606
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam07145
    Location:743 → 758
    PAM2; Ataxin-2 C-terminal region
    pfam06741
    Location:228 → 289
    LsmAD; LsmAD domain
    pfam14438
    Location:85 → 161
    SM-ATX; Ataxin 2 SM domain

  6. XM_030254251.2 → XP_030110111.1  ataxin-2 isoform X18

    Conserved Domains (6) summary
    PHA03247
    Location:762 → 1080
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174 → 318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:693 → 823
    PRK10263; DNA translocase FtsK; Provisional
    PRK12323
    Location:399 → 606
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam06741
    Location:228 → 289
    LsmAD; LsmAD domain
    pfam14438
    Location:85 → 161
    SM-ATX; Ataxin 2 SM domain

  7. XM_030254235.2 → XP_030110095.1  ataxin-2 isoform X2

    Conserved Domains (6) summary
    COG5180
    Location:174 → 318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK12323
    Location:399 → 606
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam07145
    Location:743 → 758
    PAM2; Ataxin-2 C-terminal region
    pfam03154
    Location:755 → 1142
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:228 → 289
    LsmAD; LsmAD domain
    pfam14438
    Location:85 → 161
    SM-ATX; Ataxin 2 SM domain

  8. XM_030254240.2 → XP_030110100.1  ataxin-2 isoform X8

    Conserved Domains (6) summary
    PHA03247
    Location:701 → 1019
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174 → 318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam07145
    Location:682 → 697
    PAM2; Ataxin-2 C-terminal region
    pfam06741
    Location:228 → 289
    LsmAD; LsmAD domain
    pfam11489
    Location:452 → 761
    Aim21; Altered inheritance of mitochondria protein 21
    pfam14438
    Location:85 → 161
    SM-ATX; Ataxin 2 SM domain

  9. XM_030254242.2 → XP_030110102.1  ataxin-2 isoform X10

    Conserved Domains (5) summary
    PHA03247
    Location:689 → 1007
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174 → 318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam07145
    Location:670 → 685
    PAM2; Ataxin-2 C-terminal region
    pfam06741
    Location:228 → 289
    LsmAD; LsmAD domain
    pfam14438
    Location:85 → 161
    SM-ATX; Ataxin 2 SM domain

  10. XM_030254243.1 → XP_030110103.1  ataxin-2 isoform X11

    Conserved Domains (5) summary
    COG5180
    Location:174 → 318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK12323
    Location:399 → 606
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam06741
    Location:228 → 289
    LsmAD; LsmAD domain
    pfam09770
    Location:740 → 1009
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:85 → 161
    SM-ATX; Ataxin 2 SM domain

  11. XM_030254258.2 → XP_030110118.1  ataxin-2 isoform X27

    Conserved Domains (5) summary
    PHA03247
    Location:483 → 1062
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174 → 318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam06741
    Location:228 → 289
    LsmAD; LsmAD domain
    pfam09770
    Location:740 → 1009
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:85 → 161
    SM-ATX; Ataxin 2 SM domain

  12. XM_030254241.2 → XP_030110101.1  ataxin-2 isoform X9

    Conserved Domains (6) summary
    COG5180
    Location:174 → 318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK12323
    Location:399 → 606
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam07145
    Location:743 → 758
    PAM2; Ataxin-2 C-terminal region
    pfam03154
    Location:755 → 1138
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:228 → 289
    LsmAD; LsmAD domain
    pfam14438
    Location:85 → 161
    SM-ATX; Ataxin 2 SM domain

  13. XM_030254252.2 → XP_030110112.1  ataxin-2 isoform X20

    Conserved Domains (6) summary
    COG5180
    Location:174 → 318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK12323
    Location:399 → 606
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam03154
    Location:691 → 1067
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:228 → 289
    LsmAD; LsmAD domain
    pfam09770
    Location:763 → 935
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:85 → 161
    SM-ATX; Ataxin 2 SM domain

  14. XM_030254245.1 → XP_030110105.1  ataxin-2 isoform X13

    Conserved Domains (6) summary
    COG5180
    Location:174 → 318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK12323
    Location:399 → 606
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam07145
    Location:743 → 758
    PAM2; Ataxin-2 C-terminal region
    pfam03154
    Location:755 → 1120
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:228 → 289
    LsmAD; LsmAD domain
    pfam14438
    Location:85 → 161
    SM-ATX; Ataxin 2 SM domain

  15. XM_030254259.1 → XP_030110119.1  ataxin-2 isoform X28

    Conserved Domains (6) summary
    PHA03247
    Location:485 → 940
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174 → 318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:899 → 1066
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:228 → 289
    LsmAD; LsmAD domain
    pfam09770
    Location:763 → 951
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:85 → 161
    SM-ATX; Ataxin 2 SM domain

  16. XM_017320749.2 → XP_017176238.1  ataxin-2 isoform X19

    Conserved Domains (5) summary
    PHA03247
    Location:386 → 928
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174 → 318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam03154
    Location:743 → 1098
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:228 → 289
    LsmAD; LsmAD domain
    pfam14438
    Location:85 → 161
    SM-ATX; Ataxin 2 SM domain

  17. XM_030254261.1 → XP_030110121.1  ataxin-2 isoform X30

    Conserved Domains (6) summary
    PHA03247
    Location:473 → 928
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174 → 318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:887 → 1054
    PRK10263; DNA translocase FtsK; Provisional
    pfam06741
    Location:228 → 289
    LsmAD; LsmAD domain
    pfam09770
    Location:751 → 939
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:85 → 161
    SM-ATX; Ataxin 2 SM domain

  18. XM_030254236.1 → XP_030110096.1  ataxin-2 isoform X4

    Conserved Domains (6) summary
    COG5180
    Location:174 → 318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK12323
    Location:399 → 606
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam07145
    Location:743 → 758
    PAM2; Ataxin-2 C-terminal region
    pfam03154
    Location:755 → 1126
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:228 → 289
    LsmAD; LsmAD domain
    pfam14438
    Location:85 → 161
    SM-ATX; Ataxin 2 SM domain

  19. XM_030254237.1 → XP_030110097.1  ataxin-2 isoform X5

    Conserved Domains (6) summary
    COG5180
    Location:174 → 318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK12323
    Location:399 → 606
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam07145
    Location:743 → 758
    PAM2; Ataxin-2 C-terminal region
    pfam03154
    Location:755 → 1124
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:228 → 289
    LsmAD; LsmAD domain
    pfam14438
    Location:85 → 161
    SM-ATX; Ataxin 2 SM domain

  20. XM_030254239.1 → XP_030110099.1  ataxin-2 isoform X7

    Conserved Domains (5) summary
    PHA03247
    Location:386 → 928
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174 → 318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam03154
    Location:743 → 1112
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:228 → 289
    LsmAD; LsmAD domain
    pfam14438
    Location:85 → 161
    SM-ATX; Ataxin 2 SM domain

  21. XM_030254249.1 → XP_030110109.1  ataxin-2 isoform X16

    Conserved Domains (5) summary
    PHA03247
    Location:439 → 869
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174 → 318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam03154
    Location:682 → 1053
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:228 → 289
    LsmAD; LsmAD domain
    pfam14438
    Location:85 → 161
    SM-ATX; Ataxin 2 SM domain

  22. XM_017320748.3 → XP_017176237.1  ataxin-2 isoform X3

    Conserved Domains (5) summary
    PHA03247
    Location:386 → 992
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174 → 318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam03154
    Location:743 → 1130
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:228 → 289
    LsmAD; LsmAD domain
    pfam14438
    Location:85 → 161
    SM-ATX; Ataxin 2 SM domain

  23. XM_030254246.2 → XP_030110106.1  ataxin-2 isoform X14

    Conserved Domains (6) summary
    COG5180
    Location:174 → 318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK07003
    Location:354 → 523
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam07145
    Location:661 → 676
    PAM2; Ataxin-2 C-terminal region
    pfam03154
    Location:673 → 1060
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:228 → 289
    LsmAD; LsmAD domain
    pfam14438
    Location:85 → 161
    SM-ATX; Ataxin 2 SM domain

  24. XM_036164934.1 → XP_036020827.1  ataxin-2 isoform X25

    Conserved Domains (6) summary
    PHA03247
    Location:750 → 1068
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174 → 318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK10263
    Location:681 → 811
    PRK10263; DNA translocase FtsK; Provisional
    PRK12323
    Location:387 → 569
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam06741
    Location:228 → 289
    LsmAD; LsmAD domain
    pfam14438
    Location:88 → 161
    SM-ATX; Ataxin 2 SM domain

  25. XM_030254250.2 → XP_030110110.1  ataxin-2 isoform X17

    Conserved Domains (5) summary
    PHA03247
    Location:386 → 1022
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174 → 318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam06741
    Location:228 → 289
    LsmAD; LsmAD domain
    pfam09770
    Location:728 → 997
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:85 → 161
    SM-ATX; Ataxin 2 SM domain

  26. XM_030254260.2 → XP_030110120.1  ataxin-2 isoform X29

    Related
    ENSMUSP00000124070.2, ENSMUST00000161064.8
    Conserved Domains (5) summary
    PHA03247
    Location:473 → 930
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174 → 318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam06741
    Location:228 → 289
    LsmAD; LsmAD domain
    pfam09770
    Location:728 → 997
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:85 → 161
    SM-ATX; Ataxin 2 SM domain

  27. XM_017320750.3 → XP_017176239.1  ataxin-2 isoform X26

    Conserved Domains (5) summary
    PHA03247
    Location:386 → 992
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174 → 318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam06741
    Location:228 → 289
    LsmAD; LsmAD domain
    pfam09770
    Location:751 → 923
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:85 → 161
    SM-ATX; Ataxin 2 SM domain

  28. XM_030254266.2 → XP_030110126.1  ataxin-2 isoform X35

    Conserved Domains (6) summary
    COG5180
    Location:174 → 318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK07003
    Location:354 → 523
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam03154
    Location:609 → 985
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:228 → 289
    LsmAD; LsmAD domain
    pfam09770
    Location:681 → 853
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:85 → 161
    SM-ATX; Ataxin 2 SM domain

  29. XM_030254238.2 → XP_030110098.1  ataxin-2 isoform X6

    Conserved Domains (5) summary
    PHA03247
    Location:386 → 1022
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:174 → 318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam06741
    Location:228 → 289
    LsmAD; LsmAD domain
    pfam09770
    Location:728 → 997
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:85 → 161
    SM-ATX; Ataxin 2 SM domain

  30. XM_030254255.2 → XP_030110115.1  ataxin-2 isoform X22

    Conserved Domains (6) summary
    COG5180
    Location:174 → 318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK07003
    Location:354 → 523
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam07145
    Location:661 → 676
    PAM2; Ataxin-2 C-terminal region
    pfam03154
    Location:673 → 1044
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:228 → 289
    LsmAD; LsmAD domain
    pfam14438
    Location:85 → 161
    SM-ATX; Ataxin 2 SM domain

  31. XM_030254257.2 → XP_030110117.1  ataxin-2 isoform X24

    Conserved Domains (6) summary
    COG5180
    Location:174 → 318
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK07003
    Location:354 → 523
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam07145
    Location:661 → 676
    PAM2; Ataxin-2 C-terminal region
    pfam03154
    Location:673 → 1042
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:228 → 289
    LsmAD; LsmAD domain
    pfam14438
    Location:85 → 161
    SM-ATX; Ataxin 2 SM domain

  32. XM_030254247.2 → XP_030110107.1  ataxin-2 isoform X15

    Conserved Domains (6) summary
    PHA03247
    Location:675 → 993
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:87 → 231
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK12323
    Location:312 → 519
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam07145
    Location:656 → 671
    PAM2; Ataxin-2 C-terminal region
    pfam06741
    Location:141 → 202
    LsmAD; LsmAD domain
    pfam14438
    Location:1 → 74
    SM-ATX; Ataxin 2 SM domain

  33. XM_030254253.2 → XP_030110113.1  ataxin-2 isoform X21

    Conserved Domains (6) summary
    PHA03247
    Location:663 → 981
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:87 → 231
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK12323
    Location:300 → 482
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam06741
    Location:141 → 202
    LsmAD; LsmAD domain
    pfam07145
    Location:645 → 659
    PAM2; Ataxin-2 C-terminal region
    pfam14438
    Location:1 → 74
    SM-ATX; Ataxin 2 SM domain

  34. XM_030254256.2 → XP_030110116.1  ataxin-2 isoform X23

    Conserved Domains (5) summary
    PHA03247
    Location:299 → 905
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:87 → 231
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam03154
    Location:656 → 1043
    Atrophin-1; Atrophin-1 family
    pfam06741
    Location:141 → 202
    LsmAD; LsmAD domain
    pfam14438
    Location:1 → 74
    SM-ATX; Ataxin 2 SM domain

  35. XM_030254264.2 → XP_030110124.1  ataxin-2 isoform X33

    Conserved Domains (6) summary
    PHA03247
    Location:593 → 911
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:87 → 231
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK07003
    Location:267 → 436
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam07145
    Location:574 → 589
    PAM2; Ataxin-2 C-terminal region
    pfam06741
    Location:141 → 202
    LsmAD; LsmAD domain
    pfam14438
    Location:1 → 74
    SM-ATX; Ataxin 2 SM domain

  36. XM_036164933.1 → XP_036020826.1  ataxin-2 isoform X21

    Conserved Domains (6) summary
    PHA03247
    Location:663 → 981
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:87 → 231
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK12323
    Location:300 → 482
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam06741
    Location:141 → 202
    LsmAD; LsmAD domain
    pfam07145
    Location:645 → 659
    PAM2; Ataxin-2 C-terminal region
    pfam14438
    Location:1 → 74
    SM-ATX; Ataxin 2 SM domain

  37. XM_006530228.4 → XP_006530291.1  ataxin-2 isoform X15

    Conserved Domains (6) summary
    PHA03247
    Location:675 → 993
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:87 → 231
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK12323
    Location:312 → 519
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam07145
    Location:656 → 671
    PAM2; Ataxin-2 C-terminal region
    pfam06741
    Location:141 → 202
    LsmAD; LsmAD domain
    pfam14438
    Location:1 → 74
    SM-ATX; Ataxin 2 SM domain

  38. XM_030254248.2 → XP_030110108.1  ataxin-2 isoform X15

    Conserved Domains (6) summary
    PHA03247
    Location:675 → 993
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:87 → 231
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK12323
    Location:312 → 519
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam07145
    Location:656 → 671
    PAM2; Ataxin-2 C-terminal region
    pfam06741
    Location:141 → 202
    LsmAD; LsmAD domain
    pfam14438
    Location:1 → 74
    SM-ATX; Ataxin 2 SM domain

  39. XM_030254254.2 → XP_030110114.1  ataxin-2 isoform X21

    Conserved Domains (6) summary
    PHA03247
    Location:663 → 981
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:87 → 231
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    PRK12323
    Location:300 → 482
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam06741
    Location:141 → 202
    LsmAD; LsmAD domain
    pfam07145
    Location:645 → 659
    PAM2; Ataxin-2 C-terminal region
    pfam14438
    Location:1 → 74
    SM-ATX; Ataxin 2 SM domain

RNA

  1. XR_003955602.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70305.1 GenPept UniProtKB/Swiss-Prot:O70305

Gene LinkOut

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