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STK32A serine/threonine kinase 32A [ Homo sapiens (human) ]

Gene ID: 202374, updated on 7-Jun-2020

Summary

Official Symbol
STK32Aprovided by HGNC
Official Full Name
serine/threonine kinase 32Aprovided by HGNC
Primary source
HGNC:HGNC:28317
See related
Ensembl:ENSG00000169302
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
YANK1
Expression
Broad expression in adrenal (RPKM 5.1), thyroid (RPKM 4.8) and 21 other tissues See more
Orthologs

Genomic context

See STK32A in Genome Data Viewer
Location:
5q32
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (147234963..147401996)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (146614526..146767418)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene protein phosphatase 2 regulatory subunit Bbeta Neighboring gene uncharacterized LOC105378214 Neighboring gene PPP2R2B intronic transcript 1 Neighboring gene STK32A antisense RNA 1 Neighboring gene dihydropyrimidinase like 3 Neighboring gene JAKMIP2 antisense RNA 1 Neighboring gene uncharacterized LOC101927012 Neighboring gene janus kinase and microtubule interacting protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC22688

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase 32A
Names
A930015B13Rik
CTB-108O6.2
yet another novel kinase 1
NP_001106195.1
NP_001274669.1
NP_659438.1
XP_011535878.1
XP_011535879.1
XP_011535881.1
XP_016864702.1
XP_016864703.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001112724.2NP_001106195.1  serine/threonine-protein kinase 32A isoform 1

    See identical proteins and their annotated locations for NP_001106195.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 3' UTR and coding sequence compared to variant 3. The resulting isoform (1) has a shorter and distinct C-terminus compared to isoform 3.
    Source sequence(s)
    AC009189, BC021666, DA110948, DA231845, DR006392, EB386256
    Consensus CDS
    CCDS47299.1
    UniProtKB/Swiss-Prot
    Q8WU08
    Related
    ENSP00000381030.3, ENST00000397936.8
    Conserved Domains (2) summary
    smart00220
    Location:23270
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05578
    Location:22281
    STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1
  2. NM_001287740.2NP_001274669.1  serine/threonine-protein kinase 32A isoform 3

    See identical proteins and their annotated locations for NP_001274669.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AC009189, AK315942
    Consensus CDS
    CCDS75351.1
    UniProtKB/TrEMBL
    B7Z9H7
    Related
    ENSP00000381535.3, ENST00000398523.3
    Conserved Domains (1) summary
    cd05578
    Location:22281
    STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1
  3. NM_145001.4NP_659438.1  serine/threonine-protein kinase 32A isoform 2

    See identical proteins and their annotated locations for NP_659438.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 3. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 3.
    Source sequence(s)
    AC009189, AC011338
    Consensus CDS
    CCDS54931.1
    UniProtKB/Swiss-Prot
    Q8WU08
    Related
    ENSP00000487441.1, ENST00000626951.2
    Conserved Domains (1) summary
    cl21453
    Location:22157
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    147234963..147401996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537577.2XP_011535879.1  serine/threonine-protein kinase 32A isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:23270
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05578
    Location:22281
    STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1
  2. XM_017009213.1XP_016864702.1  serine/threonine-protein kinase 32A isoform X3

    Related
    ENSP00000497167.1, ENST00000648628.1
  3. XM_011537579.2XP_011535881.1  serine/threonine-protein kinase 32A isoform X5

    See identical proteins and their annotated locations for XP_011535881.1

    Conserved Domains (2) summary
    smart00220
    Location:23220
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05578
    Location:22221
    STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1
  4. XM_011537576.1XP_011535878.1  serine/threonine-protein kinase 32A isoform X1

    Conserved Domains (2) summary
    smart00220
    Location:21268
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05578
    Location:20279
    STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1
  5. XM_017009214.1XP_016864703.1  serine/threonine-protein kinase 32A isoform X4

RNA

  1. XR_001742037.1 RNA Sequence

  2. XR_001742038.1 RNA Sequence

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