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RANBP3L RAN binding protein 3 like [ Homo sapiens (human) ]

Gene ID: 202151, updated on 24-Nov-2020

Summary

Official Symbol
RANBP3Lprovided by HGNC
Official Full Name
RAN binding protein 3 likeprovided by HGNC
Primary source
HGNC:HGNC:26353
See related
Ensembl:ENSG00000164188 MIM:616391
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in brain (RPKM 8.6), kidney (RPKM 8.4) and 11 other tissues See more
Orthologs

Genomic context

See RANBP3L in Genome Data Viewer
Location:
5p13.2
Exon count:
15
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (36246913..36301902, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (36247950..36302011, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1305, pseudogene Neighboring gene S-phase kinase associated protein 2 Neighboring gene NAD kinase 2, mitochondrial Neighboring gene NADK2 antisense RNA 1 Neighboring gene RNA, 5S ribosomal pseudogene 181 Neighboring gene ribosomal protein L39 pseudogene 22

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Impact of four loci on serum tamsulosin hydrochloride concentration.
GeneReviews: Not available
Two-marker association tests yield new disease associations for coronary artery disease and hypertension.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25422

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SMAD binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
mesenchymal cell differentiation involved in bone development ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of myoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161429.3NP_001154901.1  ran-binding protein 3-like isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC008807, AC114277, AK302947
    Consensus CDS
    CCDS54843.1
    UniProtKB/Swiss-Prot
    Q86VV4
    Related
    ENSP00000421853.1, ENST00000502994.5
    Conserved Domains (1) summary
    cd13180
    Location:316431
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain
  2. NM_001323273.2NP_001310202.1  ran-binding protein 3-like isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC008807, BC047660
    UniProtKB/Swiss-Prot
    Q86VV4
    Conserved Domains (1) summary
    cd13180
    Location:291406
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain
  3. NM_001323274.2NP_001310203.1  ran-binding protein 3-like isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC008807, AK302947, BC047660, BQ774461
    UniProtKB/Swiss-Prot
    Q86VV4
  4. NM_001323275.2NP_001310204.1  ran-binding protein 3-like isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC008807, AK302947, BC047660
    UniProtKB/Swiss-Prot
    Q86VV4
  5. NM_001323276.2NP_001310205.1  ran-binding protein 3-like isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC008807, AK302947, BC047660, BQ774461
    UniProtKB/Swiss-Prot
    Q86VV4
  6. NM_001323277.2NP_001310206.1  ran-binding protein 3-like isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC008807, BC047660, BQ774461
    UniProtKB/Swiss-Prot
    Q86VV4
  7. NM_001323278.2NP_001310207.1  ran-binding protein 3-like isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC008807, BC047660
    UniProtKB/Swiss-Prot
    Q86VV4
  8. NM_001323279.2NP_001310208.1  ran-binding protein 3-like isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC008807, BC047660
    UniProtKB/Swiss-Prot
    Q86VV4
  9. NM_001323280.2NP_001310209.1  ran-binding protein 3-like isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC008807, BC047660, BQ774461
    UniProtKB/Swiss-Prot
    Q86VV4
  10. NM_145000.5NP_659437.3  ran-binding protein 3-like isoform 2

    See identical proteins and their annotated locations for NP_659437.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    AC008807, BC047660
    Consensus CDS
    CCDS3918.1
    UniProtKB/Swiss-Prot
    Q86VV4
    Related
    ENSP00000296604.3, ENST00000296604.7
    Conserved Domains (1) summary
    cd13180
    Location:291406
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    36246913..36301902 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714455.4XP_006714518.1  ran-binding protein 3-like isoform X3

    Conserved Domains (1) summary
    cd13180
    Location:271386
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain
  2. XM_006714453.4XP_006714516.1  ran-binding protein 3-like isoform X2

    Conserved Domains (1) summary
    cd13180
    Location:296411
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain
  3. XM_006714452.4XP_006714515.1  ran-binding protein 3-like isoform X1

    Conserved Domains (1) summary
    cd13180
    Location:316431
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain
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