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Prrx2 paired related homeobox 2 [ Mus musculus (house mouse) ]

Gene ID: 20204, updated on 5-Mar-2024

Summary

Official Symbol
Prrx2provided by MGI
Official Full Name
paired related homeobox 2provided by MGI
Primary source
MGI:MGI:98218
See related
Ensembl:ENSMUSG00000039476 AllianceGenome:MGI:98218
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
S8; Prx2
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; HMG box domain binding activity; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including embryonic morphogenesis; positive regulation of mesenchymal cell proliferation; and positive regulation of smoothened signaling pathway. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; branchial arch; embryo mesenchyme; and genitourinary system. Orthologous to human PRRX2 (paired related homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in limb E14.5 (RPKM 44.2), ovary adult (RPKM 19.6) and 9 other tissues See more
Orthologs
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Genomic context

See Prrx2 in Genome Data Viewer
Location:
2 B; 2 21.74 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (30735076..30771263)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30845064..30881251)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 54110 Neighboring gene N-terminal Xaa-Pro-Lys N-methyltransferase 1 Neighboring gene STARR-positive B cell enhancer ABC_E10091 Neighboring gene ankyrin repeat and SOCS box-containing 6 Neighboring gene prostaglandin E synthase Neighboring gene predicted gene, 52550 Neighboring gene predicted gene, 57831 Neighboring gene peptidylprolyl isomerase A pseudogene 2_387.1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within artery morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cartilage development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic limb morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic skeletal system morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within inner ear morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of mesenchymal cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within middle ear morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of smoothened signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of stem cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of smoothened signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of stem cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
paired mesoderm homeobox protein 2
Names
PRX-2
homeo box of paired rule
homeobox protein S8
surface antigen, homeo box of paired rule

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009116.3NP_033142.2  paired mesoderm homeobox protein 2

    See identical proteins and their annotated locations for NP_033142.2

    Status: VALIDATED

    Source sequence(s)
    AL844532
    Consensus CDS
    CCDS15888.1
    UniProtKB/Swiss-Prot
    Q06348, Q61651
    UniProtKB/TrEMBL
    A2APZ7
    Related
    ENSMUSP00000040332.5, ENSMUST00000041659.7
    Conserved Domains (3) summary
    COG5576
    Location:109213
    COG5576; Homeodomain-containing transcription factor [Transcription]
    pfam00046
    Location:103154
    Homeobox; Homeobox domain
    pfam03826
    Location:220237
    OAR; OAR domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    30735076..30771263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497806.1XP_006497869.1  paired mesoderm homeobox protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q06348, Q61651
    Conserved Domains (2) summary
    pfam00046
    Location:103167
    Homeobox; Homeobox domain
    pfam03826
    Location:232249
    OAR; OAR domain