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S100a8 S100 calcium binding protein A8 (calgranulin A) [ Mus musculus (house mouse) ]

Gene ID: 20201, updated on 11-Apr-2024

Summary

Official Symbol
S100a8provided by MGI
Official Full Name
S100 calcium binding protein A8 (calgranulin A)provided by MGI
Primary source
MGI:MGI:88244
See related
Ensembl:ENSMUSG00000056054 AllianceGenome:MGI:88244
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p8; B8Ag; CFAg; Caga; MRP8; CP-10; 60B8Ag
Summary
Predicted to enable calcium ion binding activity and calcium-dependent protein binding activity. Acts upstream of or within astrocyte development and positive regulation of peptide secretion. Predicted to be located in cytosol and intermediate filament cytoskeleton. Predicted to be active in extracellular space. Is expressed in several structures, including bone marrow; extraembryonic component; female reproductive system; and liver. Human ortholog(s) of this gene implicated in myocarditis. Orthologous to human S100A8 (S100 calcium binding protein A8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E18 (RPKM 1430.9), liver E14 (RPKM 237.0) and 1 other tissue See more
Orthologs
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Genomic context

See S100a8 in Genome Data Viewer
Location:
3 F1; 3 39.9 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (90576378..90577341)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (90669071..90670034)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57853 Neighboring gene predicted gene, 19739 Neighboring gene S100 calcium binding protein A7A Neighboring gene S100 calcium binding protein A9 (calgranulin B) Neighboring gene predicted gene 5284

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables antioxidant activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within astrocyte development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in autocrine signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in autophagy ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chemotaxis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in leukocyte migration involved in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in leukocyte migration involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in neutrophil aggregation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neutrophil aggregation ISO
Inferred from Sequence Orthology
more info
 
involved_in neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of peptide secretion IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of peptide secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-cysteine S-nitrosylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of peptide secretion IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of peptide secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of toll-like receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of calprotectin complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein S100-A8
Names
MRP-8
S100 calcium-binding protein A8
calgranulin-A
chemotactic S100 protein
chemotactic cytokine CP-10
leukocyte L1 complex light chain
migration inhibitory factor-related protein 8
pro-inflammatory S100 cytokine

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013650.2NP_038678.1  protein S100-A8

    See identical proteins and their annotated locations for NP_038678.1

    Status: VALIDATED

    Source sequence(s)
    AK157837, AV007095
    Consensus CDS
    CCDS38507.1
    UniProtKB/Swiss-Prot
    P27005, P31724
    UniProtKB/TrEMBL
    Q53X15
    Related
    ENSMUSP00000064385.9, ENSMUST00000069927.10
    Conserved Domains (2) summary
    cd05030
    Location:386
    calgranulins; Calgranulins: S-100 domain found in proteins belonging to the Calgranulin subgroup of the S100 family of EF-hand calcium-modulated proteins, including S100A8, S100A9, and S100A12 . Note that the S-100 hierarchy, to which this Calgranulin group belongs, ...
    pfam13499
    Location:5175
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    90576378..90577341
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)