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Ryr3 ryanodine receptor 3 [ Mus musculus (house mouse) ]

Gene ID: 20192, updated on 9-Mar-2023

Summary

Official Symbol
Ryr3provided by MGI
Official Full Name
ryanodine receptor 3provided by MGI
Primary source
MGI:MGI:99684
See related
Ensembl:ENSMUSG00000057378 AllianceGenome:MGI:99684
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RYR-3; C230090H21
Summary
Predicted to enable calcium ion binding activity; calcium-induced calcium release activity; and ryanodine-sensitive calcium-release channel activity. Acts upstream of or within cellular calcium ion homeostasis and striated muscle contraction. Located in sarcoplasmic reticulum membrane. Part of junctional membrane complex. Is expressed in several structures, including central nervous system; diaphragm; hemolymphoid system; liver; and musculature. Orthologous to human RYR3 (ryanodine receptor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 3.5), bladder adult (RPKM 2.8) and 12 other tissues See more
Orthologs
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Genomic context

See Ryr3 in Genome Data Viewer
Location:
2; 2 E3- E4
Exon count:
106
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (112461699..113047755, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (112631354..113217405, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 22676 Neighboring gene ER membrane protein complex subunit 7 Neighboring gene cholinergic receptor, muscarinic 5 Neighboring gene apoptosis, caspase activation inhibitor Neighboring gene predicted gene, 26505 Neighboring gene transmembrane and coiled-coil domains 5B Neighboring gene formin 1 Neighboring gene predicted gene, 54142

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium-induced calcium release activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-induced calcium release activity ISO
Inferred from Sequence Orthology
more info
 
enables calcium-release channel activity ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables ryanodine-sensitive calcium-release channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ryanodine-sensitive calcium-release channel activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Z disc IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of calcium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
part_of junctional membrane complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in sarcolemma IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in sarcoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in sarcoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in sarcoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in smooth endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ryanodine receptor 3
Names
brain ryanodine receptor-calcium release channel
brain-type ryanodine receptor
calcium release channel
type 3 ryanodine receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319156.1NP_001306085.1  ryanodine receptor 3

    Status: VALIDATED

    Source sequence(s)
    AI851294, AK082701, AL672250, AL691423, AL732316, CJ060048
    Consensus CDS
    CCDS50661.2
    UniProtKB/TrEMBL
    A0A140LJK7
    Related
    ENSMUSP00000147250.2, ENSMUST00000208290.2
    Conserved Domains (12) summary
    smart00472
    Location:275368
    MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
    cd12877
    Location:641792
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:10721204
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    pfam00520
    Location:46194779
    Ion_trans; Ion transport protein
    pfam01365
    Location:442621
    RYDR_ITPR; RIH domain
    pfam02026
    Location:849937
    RyR; RyR domain
    pfam02815
    Location:216397
    MIR; MIR domain
    pfam06459
    Location:42324502
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:37293842
    RIH_assoc; RyR and IP3R Homology associated
    pfam13833
    Location:39333981
    EF-hand_8; EF-hand domain pair
    cd12879
    Location:13241462
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    cl19745
    Location:10207
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    112461699..113047755 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316702.3XP_017172191.1  ryanodine receptor 3 isoform X2

    Conserved Domains (11) summary
    cd12877
    Location:667818
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:10991231
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:13511489
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:46414801
    Ion_trans; Ion transport protein
    pfam01365
    Location:451632
    RYDR_ITPR; RIH domain
    pfam02026
    Location:875963
    RyR; RyR domain
    pfam02815
    Location:227408
    MIR; MIR domain
    pfam06459
    Location:42544524
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:37513864
    RIH_assoc; RyR and IP3R Homology associated
    pfam13833
    Location:39554003
    EF-hand_8; EF-hand domain pair
    cl19745
    Location:14218
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
  2. XM_017316700.3XP_017172189.1  ryanodine receptor 3 isoform X1

    Conserved Domains (11) summary
    cd12877
    Location:667818
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:10991231
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:13511489
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:46464806
    Ion_trans; Ion transport protein
    pfam01365
    Location:451632
    RYDR_ITPR; RIH domain
    pfam02026
    Location:875963
    RyR; RyR domain
    pfam02815
    Location:227408
    MIR; MIR domain
    pfam06459
    Location:42594529
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:37563869
    RIH_assoc; RyR and IP3R Homology associated
    pfam13833
    Location:39604008
    EF-hand_8; EF-hand domain pair
    cl19745
    Location:14218
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
  3. XM_017316705.3XP_017172194.1  ryanodine receptor 3 isoform X3

    UniProtKB/Swiss-Prot
    A2AGL3, Q9QY91
    Related
    ENSMUSP00000079503.6, ENSMUST00000080673.13
    Conserved Domains (11) summary
    cd12877
    Location:641792
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:10721204
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:13241462
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:46144774
    Ion_trans; Ion transport protein
    pfam01365
    Location:440621
    RYDR_ITPR; RIH domain
    pfam02026
    Location:849937
    RyR; RyR domain
    pfam02815
    Location:216397
    MIR; MIR domain
    pfam06459
    Location:42274497
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:37243837
    RIH_assoc; RyR and IP3R Homology associated
    pfam13833
    Location:39283976
    EF-hand_8; EF-hand domain pair
    cl19745
    Location:14207
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
  4. XM_017316709.3XP_017172198.1  ryanodine receptor 3 isoform X4

    Conserved Domains (7) summary
    cd12877
    Location:667818
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:10991231
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:13511489
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam01365
    Location:451632
    RYDR_ITPR; RIH domain
    pfam02026
    Location:875963
    RyR; RyR domain
    pfam02815
    Location:227408
    MIR; MIR domain
    cl19745
    Location:14218
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

RNA

  1. XR_004939164.1 RNA Sequence

  2. XR_004939166.1 RNA Sequence

  3. XR_003951556.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177652.2: Suppressed sequence

    Description
    NM_177652.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.