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Uimc1 ubiquitin interaction motif containing 1 [ Mus musculus (house mouse) ]

Gene ID: 20184, updated on 8-Feb-2024

Summary

Official Symbol
Uimc1provided by MGI
Official Full Name
ubiquitin interaction motif containing 1provided by MGI
Primary source
MGI:MGI:103185
See related
Ensembl:ENSMUSG00000025878 AllianceGenome:MGI:103185
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RIP110; Rxrip110; 9430016E08Rik; D330018D10Rik; D630032M02Rik
Summary
Enables retinoid X receptor binding activity. Predicted to be involved in several processes, including histone H2A K63-linked deubiquitination; mitotic G2 DNA damage checkpoint signaling; and regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of or within cellular response to DNA damage stimulus and chromatin organization. Predicted to be located in nuclear body. Predicted to be part of BRCA1-A complex. Orthologous to human UIMC1 (ubiquitin interaction motif containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 8.1), CNS E11.5 (RPKM 7.9) and 25 other tissues See more
Orthologs
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Genomic context

See Uimc1 in Genome Data Viewer
Location:
13 B1; 13 29.8 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (55175693..55248176, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (55027880..55100363, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31313 Neighboring gene unc-5 netrin receptor A Neighboring gene hexokinase 3 Neighboring gene STARR-seq mESC enhancer starr_34599 Neighboring gene ribosomal protein L29 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1877 Neighboring gene zinc finger protein 346 Neighboring gene STARR-positive B cell enhancer mm9_chr13:55226322-55226622 Neighboring gene predicted gene, 46415 Neighboring gene fibroblast growth factor receptor 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables K63-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables K63-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables histone binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear retinoid X receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin modification-dependent histone binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair-dependent chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in double-strand break repair ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic G2 DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic G2/M transition checkpoint NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA repair NAS
Non-traceable Author Statement
more info
PubMed 
involved_in response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of BRCA1-A complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of BRCA1-A complex ISO
Inferred from Sequence Orthology
more info
 
part_of BRCA1-A complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
BRCA1-A complex subunit RAP80
Names
receptor-associated protein 80
retinoid X receptor interacting protein 110
ubiquitin interaction motif-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293660.1NP_001280589.1  BRCA1-A complex subunit RAP80 isoform 2

    See identical proteins and their annotated locations for NP_001280589.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two in-frame exons in the coding region, compared to variant 1. The encoded protein (isoform 2) is shorter, compared to isoform 1.
    Source sequence(s)
    AK052704, AK160926
    Consensus CDS
    CCDS79189.1
    UniProtKB/TrEMBL
    A0A0R4J183
    Related
    ENSMUSP00000097095.4, ENSMUST00000099496.4
    Conserved Domains (1) summary
    pfam18282
    Location:72122
    RAP80_UIM; RAP80 N-terminal ubiquitin interaction motif
  2. NM_001359757.1NP_001346686.1  BRCA1-A complex subunit RAP80 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 and 4 encode the same isoform (1).
    Source sequence(s)
    AC154610
    Consensus CDS
    CCDS36671.1
    UniProtKB/Swiss-Prot
    Q3TU77, Q5U5Q9, Q60811, Q8C3Z8, Q8C719, Q8K1X7
    UniProtKB/TrEMBL
    A0A0R4J073, E9Q577
  3. NM_001359758.1NP_001346687.1  BRCA1-A complex subunit RAP80 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains multiple differences in the 5' region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC154610
  4. NM_011307.3NP_035437.1  BRCA1-A complex subunit RAP80 isoform 1

    See identical proteins and their annotated locations for NP_035437.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK052704, AK160926
    Consensus CDS
    CCDS36671.1
    UniProtKB/Swiss-Prot
    Q3TU77, Q5U5Q9, Q60811, Q8C3Z8, Q8C719, Q8K1X7
    UniProtKB/TrEMBL
    A0A0R4J073, E9Q577
    Related
    ENSMUSP00000026997.6, ENSMUST00000026997.12

RNA

  1. NR_121592.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK052704, AK160926
    Related
    ENSMUST00000148702.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    55175693..55248176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244499.3XP_011242801.1  BRCA1-A complex subunit RAP80 isoform X2

    UniProtKB/Swiss-Prot
    Q3TU77, Q5U5Q9, Q60811, Q8C3Z8, Q8C719, Q8K1X7
    UniProtKB/TrEMBL
    E9Q577
    Conserved Domains (1) summary
    pfam18282
    Location:72128
    RAP80_UIM; RAP80 N-terminal ubiquitin interaction motif
  2. XM_030247207.2XP_030103067.1  BRCA1-A complex subunit RAP80 isoform X6

    Conserved Domains (1) summary
    pfam18282
    Location:72122
    RAP80_UIM; RAP80 N-terminal ubiquitin interaction motif
  3. XM_006517167.4XP_006517230.1  BRCA1-A complex subunit RAP80 isoform X1

    UniProtKB/Swiss-Prot
    Q3TU77, Q5U5Q9, Q60811, Q8C3Z8, Q8C719, Q8K1X7
    UniProtKB/TrEMBL
    E9Q577
    Conserved Domains (1) summary
    pfam18282
    Location:72128
    RAP80_UIM; RAP80 N-terminal ubiquitin interaction motif
  4. XM_036157929.1XP_036013822.1  BRCA1-A complex subunit RAP80 isoform X4

    Conserved Domains (1) summary
    cd20912
    Location:122
    AIR_RAP80-like; ABRAXAS Interacting Region (AIR) of Receptor-Associated Protein 80 (RAP80), and related domains
  5. XM_036157930.1XP_036013823.1  BRCA1-A complex subunit RAP80 isoform X5

  6. XM_036157928.1XP_036013821.1  BRCA1-A complex subunit RAP80 isoform X3

    UniProtKB/TrEMBL
    A0A0R4J183
    Conserved Domains (1) summary
    pfam18282
    Location:72122
    RAP80_UIM; RAP80 N-terminal ubiquitin interaction motif

RNA

  1. XR_004937982.1 RNA Sequence

  2. XR_004937981.1 RNA Sequence