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TMEM154 transmembrane protein 154 [ Homo sapiens (human) ]

Gene ID: 201799, updated on 25-Oct-2022

Summary

Official Symbol
TMEM154provided by HGNC
Official Full Name
transmembrane protein 154provided by HGNC
Primary source
HGNC:HGNC:26489
See related
Ensembl:ENSG00000170006 AllianceGenome:HGNC:26489
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in skin (RPKM 20.4), esophagus (RPKM 13.6) and 11 other tissues See more
Orthologs
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Genomic context

See TMEM154 in Genome Data Viewer
Location:
4q31.3
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (152618628..152679997, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (155941796..156003145, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (153539780..153601149, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RPS3A pseudogene 18 Neighboring gene ribosomal protein S14 pseudogene 6 Neighboring gene uncharacterized LOC105377495 Neighboring gene tigger transposable element derived 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32028

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152680.3NP_689893.1  transmembrane protein 154 precursor

    See identical proteins and their annotated locations for NP_689893.1

    Status: VALIDATED

    Source sequence(s)
    AC023424, AC106882
    Consensus CDS
    CCDS3779.1
    UniProtKB/Swiss-Prot
    Q6P9G4, Q96MQ8
    Related
    ENSP00000302144.3, ENST00000304385.8
    Conserved Domains (1) summary
    pfam15102
    Location:24165
    TMEM154; TMEM154 protein family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    152618628..152679997 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531716.4XP_011530018.1  transmembrane protein 154 isoform X1

    UniProtKB/TrEMBL
    D6R923
    Related
    ENSP00000516115.1, ENST00000705347.1
    Conserved Domains (1) summary
    pfam15102
    Location:24124
    TMEM154; TMEM154 protein family

RNA

  1. XR_001741158.3 RNA Sequence

  2. XR_007096383.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    155941796..156003145 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)