Format

Send to:

Choose Destination

SLC10A4 solute carrier family 10 member 4 [ Homo sapiens (human) ]

Gene ID: 201780, updated on 11-Jun-2021

Summary

Official Symbol
SLC10A4provided by HGNC
Official Full Name
solute carrier family 10 member 4provided by HGNC
Primary source
HGNC:HGNC:22980
See related
Ensembl:ENSG00000145248 MIM:618563
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P4
Expression
Biased expression in adrenal (RPKM 2.6), brain (RPKM 1.4) and 8 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See SLC10A4 in Genome Data Viewer
Location:
4p11
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (48483343..48489526)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (48485360..48491543)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene SLAIN motif family member 2 Neighboring gene U6 snRNA-associated Sm-like protein LSm2 pseudogene Neighboring gene CRISPRi-validated cis-regulatory element chr4.1483 Neighboring gene zygote arrest 1 Neighboring gene FRY like transcription coactivator Neighboring gene RNA, U5E small nuclear 3, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC29802

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables bile acid:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in bile acid and bile salt transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sodium/bile acid cotransporter 4
Names
Na(+)/bile acid cotransporter 4
bile acid transporter SLC10A4
solute carrier family 10 (sodium/bile acid cotransporter family), member 4

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152679.4NP_689892.1  sodium/bile acid cotransporter 4

    See identical proteins and their annotated locations for NP_689892.1

    Status: VALIDATED

    Source sequence(s)
    AA776274, AC096952, AI421729, AK126542, BC019066
    Consensus CDS
    CCDS3482.1
    UniProtKB/Swiss-Prot
    Q96EP9
    Related
    ENSP00000273861.4, ENST00000273861.5
    Conserved Domains (1) summary
    cl19217
    Location:113385
    SBF; Sodium Bile acid symporter family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    48483343..48489526
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center