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Ruvbl2 RuvB-like AAA ATPase 2 [ Mus musculus (house mouse) ]

Gene ID: 20174, updated on 27-Feb-2024

Summary

Official Symbol
Ruvbl2provided by MGI
Official Full Name
RuvB-like AAA ATPase 2provided by MGI
Primary source
MGI:MGI:1342299
See related
Ensembl:ENSMUSG00000003868 AllianceGenome:MGI:1342299
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p47; mp47
Summary
Enables several functions, including ATPase binding activity; TFIID-class transcription factor complex binding activity; and adenyl ribonucleotide binding activity. Predicted to be involved in several processes, including box C/D snoRNP assembly; histone acetylation; and positive regulation of nitrogen compound metabolic process. Predicted to act upstream of or within DNA recombination; DNA repair; and chromatin organization. Part of ribonucleoprotein complex. Is expressed in several structures, including axial musculature; branchial arch; limb; sensory organ; and viscerocranium. Orthologous to human RUVBL2 (RuvB like AAA ATPase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 61.6), CNS E11.5 (RPKM 48.3) and 28 other tissues See more
Orthologs
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Genomic context

See Ruvbl2 in Genome Data Viewer
Location:
7 B3; 7 29.3 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45071320..45084817, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45421896..45436171, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene stabilizer of axonemal microtubules 3 Neighboring gene luteinizing hormone beta Neighboring gene STARR-positive B cell enhancer ABC_E349 Neighboring gene glycogen synthase 1, muscle Neighboring gene STARR-seq mESC enhancer starr_18840 Neighboring gene ferritin light polypeptide 1 Neighboring gene STARR-seq mESC enhancer starr_18841 Neighboring gene BCL2-associated X protein

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC144733, MGC144734

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ADP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
 
enables ATP-dependent activity, acting on DNA IEA
Inferred from Electronic Annotation
more info
 
enables ATPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables TBP-class protein binding ISO
Inferred from Sequence Orthology
more info
 
enables TFIID-class transcription factor complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables promoter-enhancer loop anchoring activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA recombination IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in box C/D snoRNP assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to UV ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to estradiol stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of protein localization to chromatin ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA repair IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of telomere maintenance in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA repair IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA strand elongation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of chromosome organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of double-strand break repair NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of Ino80 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Ino80 complex ISO
Inferred from Sequence Orthology
more info
 
part_of MLL1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of NuA4 histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
 
part_of R2TP complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of R2TP complex ISO
Inferred from Sequence Orthology
more info
 
part_of RPAP3/R2TP/prefoldin-like complex ISO
Inferred from Sequence Orthology
more info
 
part_of Swr1 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Swr1 complex ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of euchromatin ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
 
part_of nucleosome NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein folding chaperone complex ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ruvB-like 2
Names
RuvB-like protein 2
reptin
NP_001404172.1
NP_001404173.1
NP_001404174.1
NP_001404175.1
NP_035434.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417243.1NP_001404172.1  ruvB-like 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC151602
    UniProtKB/Swiss-Prot
    Q9WTM5
    UniProtKB/TrEMBL
    Q3TXT7, Q3UXP2
    Related
    ENSMUSP00000147502.2, ENSMUST00000211214.2
  2. NM_001417244.1NP_001404173.1  ruvB-like 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC151602
    UniProtKB/Swiss-Prot
    Q9WTM5
    UniProtKB/TrEMBL
    Q3TXT7, Q3UXP2
  3. NM_001417245.1NP_001404174.1  ruvB-like 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC151602
    UniProtKB/TrEMBL
    Q3UXP2
  4. NM_001417246.1NP_001404175.1  ruvB-like 2 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC151602
    UniProtKB/TrEMBL
    Q3UXP2
  5. NM_011304.4NP_035434.1  ruvB-like 2 isoform a

    See identical proteins and their annotated locations for NP_035434.1

    Status: VALIDATED

    Source sequence(s)
    AC151602
    Consensus CDS
    CCDS21243.1
    UniProtKB/Swiss-Prot
    Q9WTM5
    UniProtKB/TrEMBL
    Q3TXT7, Q3UXP2
    Related
    ENSMUSP00000103400.4, ENSMUST00000107771.12
    Conserved Domains (1) summary
    COG1224
    Location:15451
    TIP49; DNA helicase TIP49, TBP-interacting protein [Transcription]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    45071320..45084817 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)