U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rtkn rhotekin [ Mus musculus (house mouse) ]

Gene ID: 20166, updated on 5-Mar-2024

Summary

Official Symbol
Rtknprovided by MGI
Official Full Name
rhotekinprovided by MGI
Primary source
MGI:MGI:107371
See related
Ensembl:ENSMUSG00000034930 AllianceGenome:MGI:107371
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables GTPase inhibitor activity and small GTPase binding activity. Predicted to be involved in several processes, including Rho protein signal transduction; cytoskeleton-dependent cytokinesis; and septin ring organization. Predicted to act upstream of or within apoptotic process. Predicted to be located in cytosol. Predicted to be active in actomyosin contractile ring. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; liver and biliary system; and reproductive system. Orthologous to human RTKN (rhotekin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 11.3), duodenum adult (RPKM 8.2) and 27 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Rtkn in Genome Data Viewer
Location:
6 C3; 6 35.94 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (83112485..83129560)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (83135505..83152579)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E344 Neighboring gene WW domain binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E9669 Neighboring gene INO80 complex subunit B Neighboring gene RIKEN cDNA 1700003E16 gene Neighboring gene WD repeat domain 54

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in actomyosin contractile ring assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in septin ring organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in actomyosin contractile ring IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136227.2NP_001129699.1  rhotekin isoform a

    See identical proteins and their annotated locations for NP_001129699.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes isoform a.
    Source sequence(s)
    AC104324
    Consensus CDS
    CCDS51817.1
    UniProtKB/Swiss-Prot
    E9QM24, Q61192, Q8C6B2, Q8VIG7
    Related
    ENSMUSP00000065571.5, ENSMUST00000065512.11
    Conserved Domains (4) summary
    smart00742
    Location:3791
    Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
    pfam00169
    Location:333411
    PH; PH domain
    pfam08174
    Location:117270
    Anillin; Cell division protein anillin
    cl17171
    Location:309419
    PH-like; Pleckstrin homology-like domain
  2. NM_001355524.2NP_001342453.2  rhotekin isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (c) is longer and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AC104324
  3. NM_001355525.2NP_001342454.2  rhotekin isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, 5' coding region, 3' coding region, and 3' UTR, compared to variant 1. The resulting isoform (d) is shorter and has distinct N- and C-termini, compared to isoform a.
    Source sequence(s)
    AC104324
  4. NM_001410312.1NP_001397241.1  rhotekin isoform e

    Status: VALIDATED

    Source sequence(s)
    AC104324
  5. NM_001410313.1NP_001397242.1  rhotekin isoform e

    Status: VALIDATED

    Source sequence(s)
    AC104324
  6. NM_001410314.1NP_001397243.1  rhotekin isoform f

    Status: VALIDATED

    Source sequence(s)
    AC104324
  7. NM_001410315.1NP_001397244.1  rhotekin isoform g

    Status: VALIDATED

    Source sequence(s)
    AC104324
  8. NM_001410316.1NP_001397245.1  rhotekin isoform h

    Status: VALIDATED

    Source sequence(s)
    AC104324
  9. NM_009106.3NP_033132.2  rhotekin isoform b

    See identical proteins and their annotated locations for NP_033132.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (b) is shorter and has a distinct N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AC104324
    Consensus CDS
    CCDS20274.1
    UniProtKB/Swiss-Prot
    Q8C6B2
    Related
    ENSMUSP00000112501.2, ENSMUST00000121093.8
    Conserved Domains (4) summary
    smart00742
    Location:2378
    Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
    pfam00169
    Location:320398
    PH; PH domain
    pfam08174
    Location:104257
    Anillin; Cell division protein anillin
    cl17171
    Location:296406
    PH-like; Pleckstrin homology-like domain
  10. NM_133641.3NP_598396.2  rhotekin isoform b

    See identical proteins and their annotated locations for NP_598396.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (b) is shorter and has a distinct N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AC104324
    Consensus CDS
    CCDS20274.1
    UniProtKB/Swiss-Prot
    Q8C6B2
    Related
    ENSMUSP00000085249.5, ENSMUST00000087938.11
    Conserved Domains (4) summary
    smart00742
    Location:2378
    Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
    pfam00169
    Location:320398
    PH; PH domain
    pfam08174
    Location:104257
    Anillin; Cell division protein anillin
    cl17171
    Location:296406
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    83112485..83129560
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505810.5XP_006505873.1  rhotekin isoform X4

    See identical proteins and their annotated locations for XP_006505873.1

    Conserved Domains (3) summary
    pfam08174
    Location:67220
    Anillin; Cell division protein anillin
    cl00087
    Location:141
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    cl17171
    Location:259314
    PH-like; Pleckstrin homology-like domain
  2. XM_006505807.3XP_006505870.1  rhotekin isoform X2

    Conserved Domains (3) summary
    smart00742
    Location:3791
    Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
    pfam08174
    Location:117270
    Anillin; Cell division protein anillin
    cl17171
    Location:309364
    PH-like; Pleckstrin homology-like domain
  3. XM_006505808.3XP_006505871.1  rhotekin isoform X3

    See identical proteins and their annotated locations for XP_006505871.1

    Conserved Domains (3) summary
    smart00742
    Location:2378
    Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
    pfam08174
    Location:104257
    Anillin; Cell division protein anillin
    cl17171
    Location:296351
    PH-like; Pleckstrin homology-like domain
  4. XM_006505809.3XP_006505872.1  rhotekin isoform X3

    See identical proteins and their annotated locations for XP_006505872.1

    Conserved Domains (3) summary
    smart00742
    Location:2378
    Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
    pfam08174
    Location:104257
    Anillin; Cell division protein anillin
    cl17171
    Location:296351
    PH-like; Pleckstrin homology-like domain
  5. XM_006505811.3XP_006505874.1  rhotekin isoform X4

    See identical proteins and their annotated locations for XP_006505874.1

    Conserved Domains (3) summary
    pfam08174
    Location:67220
    Anillin; Cell division protein anillin
    cl00087
    Location:141
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    cl17171
    Location:259314
    PH-like; Pleckstrin homology-like domain
  6. XM_030255274.2XP_030111134.1  rhotekin isoform X7

    Conserved Domains (3) summary
    smart00742
    Location:2378
    Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
    pfam08174
    Location:104257
    Anillin; Cell division protein anillin
    cl17171
    Location:296406
    PH-like; Pleckstrin homology-like domain
  7. XM_006505805.4XP_006505868.1  rhotekin isoform X1

    Conserved Domains (3) summary
    smart00742
    Location:82135
    Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
    pfam08174
    Location:161314
    Anillin; Cell division protein anillin
    cl17171
    Location:353408
    PH-like; Pleckstrin homology-like domain
  8. XM_006505812.2XP_006505875.1  rhotekin isoform X4

    See identical proteins and their annotated locations for XP_006505875.1

    Conserved Domains (3) summary
    pfam08174
    Location:67220
    Anillin; Cell division protein anillin
    cl00087
    Location:141
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    cl17171
    Location:259314
    PH-like; Pleckstrin homology-like domain