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TIGIT T cell immunoreceptor with Ig and ITIM domains [ Homo sapiens (human) ]

Gene ID: 201633, updated on 1-Aug-2020

Summary

Official Symbol
TIGITprovided by HGNC
Official Full Name
T cell immunoreceptor with Ig and ITIM domainsprovided by HGNC
Primary source
HGNC:HGNC:26838
See related
Ensembl:ENSG00000181847 MIM:612859
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VSIG9; VSTM3; WUCAM
Summary
This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.[provided by RefSeq, Sep 2009]
Expression
Biased expression in lymph node (RPKM 15.1), spleen (RPKM 5.9) and 7 other tissues See more
Orthologs

Genomic context

See TIGIT in Genome Data Viewer
Location:
3q13.31
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (114291102..114329747)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (114012833..114029135)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986115 Neighboring gene ZNF80-LTR promoter Neighboring gene family with sequence similarity 214 member B pseudogene Neighboring gene zinc finger protein 80 Neighboring gene ZBTB20 antisense RNA 1 Neighboring gene zinc finger and BTB domain containing 20 Neighboring gene microRNA 568 Neighboring gene ZBTB20 antisense RNA 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39873, DKFZp667A205

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of T cell activation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-12 production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of interleukin-12 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-10 production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of interleukin-10 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
T-cell immunoreceptor with Ig and ITIM domains
Names
V-set and immunoglobulin domain containing 9
V-set and immunoglobulin domain-containing protein 9
V-set and transmembrane domain containing 3
V-set and transmembrane domain-containing protein 3
VSIG9, VSTM3
Washington University cell adhesion molecule

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173799.4NP_776160.2  T-cell immunoreceptor with Ig and ITIM domains precursor

    See identical proteins and their annotated locations for NP_776160.2

    Status: VALIDATED

    Source sequence(s)
    AC093010, BC101289, BX640915, EU675310
    Consensus CDS
    CCDS2980.1
    UniProtKB/Swiss-Prot
    Q495A1
    Related
    ENSP00000373167.3, ENST00000383671.8
    Conserved Domains (1) summary
    cl11960
    Location:39127
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    114291102..114329747
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453388.1XP_024309156.1  T-cell immunoreceptor with Ig and ITIM domains isoform X1

    Related
    ENSP00000419085.1, ENST00000486257.5
    Conserved Domains (1) summary
    cl11960
    Location:39127
    Ig; Immunoglobulin domain

RNA

  1. XR_002959502.1 RNA Sequence

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