Rsu1 Ras suppressor protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rsu1provided by MGI
Official Full Name: Ras suppressor protein 1provided by MGI
Primary source: MGI:MGI:103040
See related: Ensembl:ENSMUSG00000026727 AllianceGenome:MGI:103040
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RsuI; rsp-1
Summary: Acts upstream of or within Ras protein signal transduction and positive regulation of neural precursor cell proliferation. Predicted to be located in focal adhesion. Is expressed in brain and telencephalon. Orthologous to human RSU1 (Ras suppressor protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 59.3), subcutaneous fat pad adult (RPKM 30.5) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2; 2 A1

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (13081778..13276255, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (13076967..13271438, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rsu-1 interacts with the LIM 5 domain of PINCH1 in mammalian cells and functions, in part, by altering cell adhesion.
Title: The Ras suppressor Rsu-1 binds to the LIM 5 domain of the adaptor protein PINCH1 and participates in adhesion-related functions.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2Mit427 (e-PCR), detects polymorphism
- UniSTS:129335

26.MMHAP64FRA11.seq (e-PCR)
- UniSTS:123747

d17mit8 (e-PCR)
- UniSTS:121194

Homology

Homologs of the Rsu1 gene: The Rsu1 gene is conserved in human, chimpanzee, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, and frog.
Orthologs from Annotation Pipeline: 498 organisms have orthologs with human gene Rsu1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Ras protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neural precursor cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of neural precursor cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in focal adhesion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ras suppressor protein 1

Names: rsu-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.