Format

Send to:

Choose Destination

PDE12 phosphodiesterase 12 [ Homo sapiens (human) ]

Gene ID: 201626, updated on 4-Oct-2020

Summary

Official Symbol
PDE12provided by HGNC
Official Full Name
phosphodiesterase 12provided by HGNC
Primary source
HGNC:HGNC:25386
See related
Ensembl:ENSG00000174840 MIM:616519
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
2-PDE; 2'-PDE
Expression
Ubiquitous expression in adrenal (RPKM 3.9), thyroid (RPKM 3.9) and 25 other tissues See more
Orthologs

Genomic context

See PDE12 in Genome Data Viewer
Location:
3p14.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (57556274..57656495)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (57541882..57640704)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene dynein axonemal heavy chain 12 Neighboring gene RNA, U6 small nuclear 108, pseudogene Neighboring gene RNA, U6 small nuclear 483, pseudogene Neighboring gene RNA, U6atac small nuclear 26, pseudogene Neighboring gene ARF4 antisense RNA 1 Neighboring gene ADP ribosylation factor 4 Neighboring gene DENN domain containing 6A Neighboring gene DENND6A divergent transcript Neighboring gene sarcolemma associated protein Neighboring gene PDHA1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3'-5'-exoribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
3'-5'-exoribonuclease activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
exonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
exonuclease activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
oligoribonucleotidase activity TAS
Traceable Author Statement
more info
 
poly(A)-specific ribonuclease activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
2',5'-phosphodiesterase 12
Names
2'-phosphodiesterase
mitochondrial deadenylase
NP_001309105.1
NP_001309106.1
NP_808881.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001322176.2NP_001309105.1  2',5'-phosphodiesterase 12 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. These differences result in a shorter protein (isoform 2) with a distinct C-terminus, compared to isoform 1. Isoform 2 may lack phospodiesterase or deadenylase activty.
    Source sequence(s)
    AC092418, AC114480, BM713922
    Conserved Domains (1) summary
    cl00490
    Location:299462
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  2. NM_001322177.2NP_001309106.1  2',5'-phosphodiesterase 12 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR, compared to variant 1. These differences result in a shorter protein (isoform 3) with a distinct C-terminus, compared to isoform 1. Isoform 3 may lack phospodiesterase or deadenylase activty.
    Source sequence(s)
    AC092418, BC034978, U79276
    Consensus CDS
    CCDS82792.1
    UniProtKB/TrEMBL
    F6T1Q0
    Related
    ENSP00000420626.1, ENST00000487257.1
    Conserved Domains (1) summary
    cl00490
    Location:299462
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  3. NM_177966.7NP_808881.3  2',5'-phosphodiesterase 12 isoform 1 precursor

    See identical proteins and their annotated locations for NP_808881.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the canonical protein (isoform 1).
    Source sequence(s)
    AC092418, AL831824, U79276
    Consensus CDS
    CCDS33772.1
    UniProtKB/Swiss-Prot
    Q6L8Q7
    Related
    ENSP00000309142.7, ENST00000311180.9
    Conserved Domains (1) summary
    cl00490
    Location:299608
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    57556274..57656495
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center