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STT3B STT3 oligosaccharyltransferase complex catalytic subunit B [ Homo sapiens (human) ]

Gene ID: 201595, updated on 7-Jun-2020

Summary

Official Symbol
STT3Bprovided by HGNC
Official Full Name
STT3 oligosaccharyltransferase complex catalytic subunit Bprovided by HGNC
Primary source
HGNC:HGNC:30611
See related
Ensembl:ENSG00000163527 MIM:608605
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIMP; CDG1X; STT3-B
Summary
The protein encoded by this gene is a catalytic subunit of a protein complex that transfers oligosaccharides onto asparagine residues. Defects in this gene are a cause of congenital disorder of glycosylation Ix (CDG1X). [provided by RefSeq, Jun 2014]
Expression
Ubiquitous expression in testis (RPKM 42.8), thyroid (RPKM 37.3) and 25 other tissues See more
Orthologs

Genomic context

See STT3B in Genome Data Viewer
Location:
3p23
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (31532638..31637621)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (31574130..31677556)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377019 Neighboring gene THRAP3 pseudogene 1 Neighboring gene oxysterol binding protein like 10 Neighboring gene OSBPL10 antisense RNA 1 Neighboring gene zinc finger protein 587 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Congenital disorder of glycosylation type 1x
MedGen: C2931007 OMIM: 615597 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association study of periodontal health measured by probing depth in adults ages 18-49 years.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ90106

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dolichyl-diphosphooligosaccharide-protein glycotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dolichyl-diphosphooligosaccharide-protein glycotransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
dolichyl-diphosphooligosaccharide-protein glycotransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
co-translational protein modification IMP
Inferred from Mutant Phenotype
more info
PubMed 
glycoprotein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
post-translational protein modification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
post-translational protein modification IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein N-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein N-linked glycosylation via asparagine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein N-linked glycosylation via asparagine IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein N-linked glycosylation via asparagine ISS
Inferred from Sequence or Structural Similarity
more info
 
response to unfolded protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin-dependent ERAD pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
oligosaccharyltransferase I complex ISS
Inferred from Sequence or Structural Similarity
more info
 
oligosaccharyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
oligosaccharyltransferase complex TAS
Traceable Author Statement
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B
Names
STT3, subunit of the oligosaccharyltransferase complex, homolog B
STT3B, catalytic subunit of the oligosaccharyltransferase complex
STT3B, subunit of the oligosaccharyltransferase complex (catalytic)
dolichyl-diphosphooligosaccharide protein glycotransferase
homolog of yeast STT3
oligosaccharyl transferase subunit STT3B
source of immunodominant MHC-associated peptides homolog
NP_849193.1
XP_011531767.1
XP_016861346.1
XP_016861347.1
XP_016861348.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034164.1 RefSeqGene

    Range
    5425..110116
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_178862.3NP_849193.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

    See identical proteins and their annotated locations for NP_849193.1

    Status: REVIEWED

    Source sequence(s)
    AC104643, AI914841, AK075380, AY074880, HY015137, HY039873
    Consensus CDS
    CCDS2650.1
    UniProtKB/Swiss-Prot
    Q8TCJ2
    Related
    ENSP00000295770.2, ENST00000295770.4
    Conserved Domains (1) summary
    pfam02516
    Location:71563
    STT3; Oligosaccharyl transferase STT3 subunit

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    31532638..31637621
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005857.2XP_016861346.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B isoform X1

    Conserved Domains (2) summary
    COG1287
    Location:70789
    Stt3; Asparagine N-glycosylation enzyme, membrane subunit Stt3 [Posttranslational modification, protein turnover, chaperones]
    pfam02516
    Location:71563
    STT3; Oligosaccharyl transferase STT3 subunit
  2. XM_011533465.1XP_011531767.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B isoform X4

    See identical proteins and their annotated locations for XP_011531767.1

    Conserved Domains (1) summary
    pfam02516
    Location:71442
    STT3; Oligosaccharyl transferase STT3 subunit
  3. XM_017005859.2XP_016861348.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B isoform X3

  4. XM_017005858.1XP_016861347.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B isoform X2

    Conserved Domains (1) summary
    pfam02516
    Location:1417
    STT3; Oligosaccharyl transferase STT3 subunit
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