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ZNF584 zinc finger protein 584 [ Homo sapiens (human) ]

Gene ID: 201514, updated on 23-Nov-2021

Summary

Official Symbol
ZNF584provided by HGNC
Official Full Name
zinc finger protein 584provided by HGNC
Primary source
HGNC:HGNC:27318
See related
Ensembl:ENSG00000171574
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in brain (RPKM 2.4), skin (RPKM 2.3) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF584 in Genome Data Viewer
Location:
19q13.43
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (58401472..58431396)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58920016..58929694)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ring finger protein 225 Neighboring gene long intergenic non-protein coding RNA 2560 Neighboring gene zinc finger protein 132 Neighboring gene zinc finger protein 250 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39899

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318002.2NP_001304931.1  zinc finger protein 584 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region and contains an alternate exon the in the 3' coding region that results in a frameshift compared to variant 1. It encodes isoform 2, which is shorter than and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC012313, AK290068, AK298929, BC033149, DB053426, DC350090
    Consensus CDS
    CCDS82414.1
    UniProtKB/Swiss-Prot
    Q8IVC4
    UniProtKB/TrEMBL
    B4DQS1, F6W0P0
    Related
    ENSP00000320731.7, ENST00000322834.7
    Conserved Domains (2) summary
    smart00349
    Location:969
    KRAB; krueppel associated box
    pfam01352
    Location:948
    KRAB; KRAB box
  2. NM_001363680.1NP_001350609.1  zinc finger protein 584 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK290068, BC033149, BX333264, DB062261
    Consensus CDS
    CCDS86814.1
    Related
    ENSP00000471105.1, ENST00000593920.5
    Conserved Domains (2) summary
    COG5048
    Location:144329
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:171191
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_173548.3NP_775819.1  zinc finger protein 584 isoform 1

    See identical proteins and their annotated locations for NP_775819.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC012313, AK290068, BC033149, DC350090
    Consensus CDS
    CCDS12979.1
    UniProtKB/Swiss-Prot
    Q8IVC4
    Related
    ENSP00000306756.3, ENST00000306910.9
    Conserved Domains (6) summary
    smart00349
    Location:1777
    KRAB; krueppel associated box
    COG5048
    Location:189374
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:216236
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:214236
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:1756
    KRAB; KRAB box
    pfam13465
    Location:229253
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_134461.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site and contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC012313, AK290068, BC017651, BC033149, BM828452, DC350090
    Related
    ENST00000599238.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    58401472..58431396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258628.5XP_005258685.1  zinc finger protein 584 isoform X1

    Conserved Domains (6) summary
    smart00349
    Location:969
    KRAB; krueppel associated box
    COG5048
    Location:181366
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:208228
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:206228
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:948
    KRAB; KRAB box
    pfam13465
    Location:221245
    zf-H2C2_2; Zinc-finger double domain
  2. XM_005258630.5XP_005258687.1  zinc finger protein 584 isoform X3

    Conserved Domains (2) summary
    smart00349
    Location:1777
    KRAB; krueppel associated box
    pfam01352
    Location:1756
    KRAB; KRAB box

RNA

  1. XR_002958283.1 RNA Sequence

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