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RAB12 RAB12, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 201475, updated on 17-Jun-2019

Summary

Official Symbol
RAB12provided by HGNC
Official Full Name
RAB12, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:31332
See related
Ensembl:ENSG00000206418 MIM:616448
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in heart (RPKM 8.8), fat (RPKM 6.8) and 25 other tissues See more
Orthologs

Genomic context

See RAB12 in Genome Data Viewer
Location:
18p11.22
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (8609428..8639383)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (8609443..8639380)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene thymocyte selection associated family member 3, pseudogene Neighboring gene aldo-keto reductase family 1 member B1 pseudogene 6 Neighboring gene TOMM20 pseudogene 3 Neighboring gene gastric cancer associated transcript 2 Neighboring gene microtubule crosslinking factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • RAB GEFs exchange GTP for GDP on RABs, organism-specific biosystem (from REACTOME)
    RAB GEFs exchange GTP for GDP on RABs, organism-specific biosystemHuman cells have more than 60 RAB proteins that are key regulators of intracellular membrane trafficking. These small GTPases contribute to trafficking specificity by localizing to the membranes of d...
  • RAB geranylgeranylation, organism-specific biosystem (from REACTOME)
    RAB geranylgeranylation, organism-specific biosystemHuman cells have more than 60 RAB proteins that are involved in trafficking of proteins in the endolysosomal system. These small GTPases contribute to trafficking specificity by localizing to the mem...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ45927, MGC104724

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GDP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Rab protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagy IEA
Inferred from Electronic Annotation
more info
 
cellular protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to interferon-gamma IEA
Inferred from Electronic Annotation
more info
 
endosome to lysosome transport ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of macroautophagy IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagosome IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
lysosome ISS
Inferred from Sequence or Structural Similarity
more info
 
phagocytic vesicle IEA
Inferred from Electronic Annotation
more info
 
recycling endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
recycling endosome membrane TAS
Traceable Author Statement
more info
 
trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ras-related protein Rab-12
Names
putative Ras-related protein Rab-12

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025300.2NP_001020471.2  ras-related protein Rab-12

    See identical proteins and their annotated locations for NP_001020471.2

    Status: VALIDATED

    Source sequence(s)
    AK127824, AP001793, BC050338
    Consensus CDS
    CCDS42410.1
    UniProtKB/Swiss-Prot
    Q6IQ22
    Related
    ENSP00000331748.6, ENST00000329286.7
    Conserved Domains (1) summary
    cd04120
    Location:43244
    Rab12; Rab GTPase family 12 (Rab12)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    8609428..8639383
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006722300.3XP_006722363.1  ras-related protein Rab-12 isoform X1

    Conserved Domains (1) summary
    cl21455
    Location:14212
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RNA

  1. XR_001753165.1 RNA Sequence

  2. XR_001753166.1 RNA Sequence

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