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FBXO15 F-box protein 15 [ Homo sapiens (human) ]

Gene ID: 201456, updated on 1-Jun-2020

Summary

Official Symbol
FBXO15provided by HGNC
Official Full Name
F-box protein 15provided by HGNC
Primary source
HGNC:HGNC:13617
See related
Ensembl:ENSG00000141665 MIM:609093
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBX15
Summary
Members of the F-box protein family, such as FBXO15, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in testis (RPKM 2.7), kidney (RPKM 0.4) and 3 other tissues See more
Orthologs

Genomic context

See FBXO15 in Genome Data Viewer
Location:
18q22.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (74073343..74147834, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (71740588..71815100, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372191 Neighboring gene RNA, 7SL, cytoplasmic 401, pseudogene Neighboring gene translocase of inner mitochondrial membrane 21 Neighboring gene RNA, 7SL, cytoplasmic 551, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study of sleep habits and insomnia.
NHGRI GWA Catalog
A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.
NHGRI GWA Catalog
A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.
NHGRI GWA Catalog
Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.
NHGRI GWA Catalog
Genetics of coronary artery calcification among African Americans, a meta-analysis.
NHGRI GWA Catalog
Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC39671

Gene Ontology Provided by GOA

Process Evidence Code Pubs
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein polyubiquitination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142958.2NP_001136430.1  F-box only protein 15 isoform 2

    See identical proteins and their annotated locations for NP_001136430.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region, and uses an upstream start codon, compared to variant 1. The resulting protein (isoform 2) is longer and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK094215, BU729305, DB447209
    Consensus CDS
    CCDS45884.1
    UniProtKB/Swiss-Prot
    Q8NCQ5
    Related
    ENSP00000393154.2, ENST00000419743.7
    Conserved Domains (1) summary
    pfam12937
    Location:74118
    F-box-like; F-box-like
  2. NM_152676.3NP_689889.1  F-box only protein 15 isoform 1

    See identical proteins and their annotated locations for NP_689889.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter protein (isoform 1).
    Source sequence(s)
    AC084702, BC029579, BI829755, BU729305
    UniProtKB/Swiss-Prot
    Q8NCQ5
    UniProtKB/TrEMBL
    A0A024R389
    Conserved Domains (1) summary
    pfam12937
    Location:242
    F-box-like; F-box-like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    74073343..74147834 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525856.1XP_011524158.1  F-box only protein 15 isoform X1

    Conserved Domains (1) summary
    pfam12937
    Location:74118
    F-box-like; F-box-like
  2. XM_017025603.2XP_016881092.1  F-box only protein 15 isoform X3

    UniProtKB/Swiss-Prot
    Q8NCQ5
    UniProtKB/TrEMBL
    A0A024R389
    Conserved Domains (1) summary
    pfam12937
    Location:242
    F-box-like; F-box-like
  3. XM_017025604.2XP_016881093.1  F-box only protein 15 isoform X3

    UniProtKB/Swiss-Prot
    Q8NCQ5
    UniProtKB/TrEMBL
    A0A024R389
    Conserved Domains (1) summary
    pfam12937
    Location:242
    F-box-like; F-box-like
  4. XM_011525860.1XP_011524162.1  F-box only protein 15 isoform X6

    Conserved Domains (1) summary
    pfam12937
    Location:74118
    F-box-like; F-box-like
  5. XM_024451099.1XP_024306867.1  F-box only protein 15 isoform X2

    Conserved Domains (1) summary
    pfam12937
    Location:74118
    F-box-like
  6. XM_011525859.2XP_011524161.1  F-box only protein 15 isoform X5

    Conserved Domains (1) summary
    pfam12937
    Location:74118
    F-box-like; F-box-like
  7. XM_011525858.2XP_011524160.1  F-box only protein 15 isoform X4

    Conserved Domains (1) summary
    pfam12937
    Location:74118
    F-box-like; F-box-like
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