Format

Send to:

Choose Destination

SPNS3 sphingolipid transporter 3 (putative) [ Homo sapiens (human) ]

Gene ID: 201305, updated on 1-Jun-2020

Summary

Official Symbol
SPNS3provided by HGNC
Official Full Name
sphingolipid transporter 3 (putative)provided by HGNC
Primary source
HGNC:HGNC:28433
See related
Ensembl:ENSG00000182557 MIM:611701
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLC62A3
Expression
Biased expression in bone marrow (RPKM 8.7), spleen (RPKM 1.4) and 4 other tissues See more
Orthologs

Genomic context

See SPNS3 in Genome Data Viewer
Location:
17p13.2
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (4433940..4488204)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (4337219..4391499)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ubiquitin conjugating enzyme E2 G1 Neighboring gene major facilitator superfamily domain containing 1 pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 774, pseudogene Neighboring gene uncharacterized LOC107985053 Neighboring gene sphingolipid transporter 2 Neighboring gene MYB binding protein 1a

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC29671

Gene Ontology Provided by GOA

Function Evidence Code Pubs
transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
lipid transport IEA
Inferred from Electronic Annotation
more info
 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein spinster homolog 3
Names
SPNS sphingolipid transporter 3 (putative)
spinster homolog 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320449.2NP_001307378.1  protein spinster homolog 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC116910, AK172832, BC023646
    UniProtKB/Swiss-Prot
    Q6ZMD2
    Conserved Domains (2) summary
    cd06174
    Location:10339
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:9287
    MFS_1; Major Facilitator Superfamily
  2. NM_182538.5NP_872344.3  protein spinster homolog 3 isoform 1

    See identical proteins and their annotated locations for NP_872344.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC116910, AC127521, AK172832
    Consensus CDS
    CCDS11045.1
    UniProtKB/Swiss-Prot
    Q6ZMD2
    Related
    ENSP00000347721.2, ENST00000355530.7
    Conserved Domains (2) summary
    cd06174
    Location:49466
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:51414
    MFS_1; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    4433940..4488204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523724.1XP_011522026.1  protein spinster homolog 3 isoform X2

    Conserved Domains (2) summary
    cd06174
    Location:49393
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:51389
    MFS_1; Major Facilitator Superfamily
  2. XM_011523723.1XP_011522025.1  protein spinster homolog 3 isoform X1

    Conserved Domains (2) summary
    cd06174
    Location:49374
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:51374
    MFS_1; Major Facilitator Superfamily
  3. XM_011523725.1XP_011522027.1  protein spinster homolog 3 isoform X3

    Conserved Domains (2) summary
    cd06174
    Location:49415
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:51363
    MFS_1; Major Facilitator Superfamily
  4. XM_011523726.2XP_011522028.1  protein spinster homolog 3 isoform X4

    Conserved Domains (2) summary
    cd06174
    Location:1353
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:1301
    MFS_1; Major Facilitator Superfamily
  5. XM_011523728.2XP_011522030.1  protein spinster homolog 3 isoform X5

    Conserved Domains (1) summary
    pfam07690
    Location:4218
    MFS_1; Major Facilitator Superfamily
  6. XM_017024345.2XP_016879834.1  protein spinster homolog 3 isoform X6

RNA

  1. XR_934008.1 RNA Sequence

Support Center