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TRIM65 tripartite motif containing 65 [ Homo sapiens (human) ]

Gene ID: 201292, updated on 6-Sep-2022

Summary

Official Symbol
TRIM65provided by HGNC
Official Full Name
tripartite motif containing 65provided by HGNC
Primary source
HGNC:HGNC:27316
See related
Ensembl:ENSG00000141569 MIM:619408; AllianceGenome:HGNC:27316
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
4732463G12Rik
Summary
Predicted to enable zinc ion binding activity. Involved in positive regulation of autophagy. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen (RPKM 5.1), lung (RPKM 4.3) and 25 other tissues See more
Orthologs
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Genomic context

See TRIM65 in Genome Data Viewer
Location:
17q25.1
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (75879537..75896951, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (76782114..76790102, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (73885044..73893032, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12387 Neighboring gene tripartite motif containing 47 Neighboring gene mitochondrial ribosomal protein L38 Neighboring gene Sharpr-MPRA regulatory region 10813 Neighboring gene Fas binding factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in positive regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
tripartite motif-containing protein 65

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256124.2NP_001243053.1  tripartite motif-containing protein 65 isoform 2

    See identical proteins and their annotated locations for NP_001243053.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC087289, BC021259, BG701649, BG753016, DR002345
    UniProtKB/Swiss-Prot
    Q6PJ69
    Conserved Domains (4) summary
    cd00021
    Location:94130
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd00162
    Location:1154
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam15898
    Location:123173
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    cd12896
    Location:307479
    SPRY_PRY_TRIM65; PRY/SPRY domain in tripartite motif-containing domain 65 (TRIM65)
  2. NM_173547.4NP_775818.2  tripartite motif-containing protein 65 isoform 1

    See identical proteins and their annotated locations for NP_775818.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC087289, AI242308, BC021259
    Consensus CDS
    CCDS11732.1
    UniProtKB/Swiss-Prot
    Q6PJ69, Q9BRP6
    Related
    ENSP00000269383.3, ENST00000269383.8
    Conserved Domains (4) summary
    cd00021
    Location:94130
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd00162
    Location:1154
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam15898
    Location:123173
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    cd12896
    Location:322501
    SPRY_PRY_TRIM65; PRY/SPRY domain in tripartite motif-containing domain 65 (TRIM65)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    75879537..75896951 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047435584.1XP_047291540.1  tripartite motif-containing protein 65 isoform X10

  2. XM_047435583.1XP_047291539.1  tripartite motif-containing protein 65 isoform X7

  3. XM_011524501.3XP_011522803.1  tripartite motif-containing protein 65 isoform X8

    Conserved Domains (3) summary
    cd00021
    Location:94130
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd00162
    Location:1154
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl02614
    Location:320362
    SPRY; SPRY domain
  4. XM_011524499.3XP_011522801.1  tripartite motif-containing protein 65 isoform X5

    Conserved Domains (3) summary
    cd00021
    Location:94130
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd00162
    Location:1154
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl02614
    Location:335384
    SPRY; SPRY domain
  5. XM_011524502.3XP_011522804.1  tripartite motif-containing protein 65 isoform X9

    Conserved Domains (3) summary
    cd00021
    Location:94130
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd00162
    Location:1154
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl02614
    Location:320353
    SPRY; SPRY domain
  6. XM_011524500.3XP_011522802.1  tripartite motif-containing protein 65 isoform X6

    Conserved Domains (3) summary
    cd00021
    Location:94130
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd00162
    Location:1154
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl02614
    Location:335375
    SPRY; SPRY domain
  7. XM_047435585.1XP_047291541.1  tripartite motif-containing protein 65 isoform X11

  8. XM_017024344.2XP_016879833.1  tripartite motif-containing protein 65 isoform X13

    Related
    ENSP00000444607.1, ENST00000540128.1
    Conserved Domains (2) summary
    cd00021
    Location:94130
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd00162
    Location:1154
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  9. XM_047435581.1XP_047291537.1  tripartite motif-containing protein 65 isoform X2

  10. XM_011524503.3XP_011522805.1  tripartite motif-containing protein 65 isoform X12

    Conserved Domains (2) summary
    cd00021
    Location:94130
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd00162
    Location:1154
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  11. XM_006721761.4XP_006721824.1  tripartite motif-containing protein 65 isoform X4

    Conserved Domains (3) summary
    cd00021
    Location:94130
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd00162
    Location:1154
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd12896
    Location:320492
    SPRY_PRY_TRIM65; PRY/SPRY domain in tripartite motif-containing domain 65 (TRIM65)
  12. XM_006721760.4XP_006721823.1  tripartite motif-containing protein 65 isoform X3

    Conserved Domains (3) summary
    cd00021
    Location:94130
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd00162
    Location:1154
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd12896
    Location:335514
    SPRY_PRY_TRIM65; PRY/SPRY domain in tripartite motif-containing domain 65 (TRIM65)
  13. XM_047435580.1XP_047291536.1  tripartite motif-containing protein 65 isoform X1

RNA

  1. XR_934419.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    76782114..76790102 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)