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LRRC45 leucine rich repeat containing 45 [ Homo sapiens (human) ]

Gene ID: 201255, updated on 26-Nov-2021

Summary

Official Symbol
LRRC45provided by HGNC
Official Full Name
leucine rich repeat containing 45provided by HGNC
Primary source
HGNC:HGNC:28302
See related
Ensembl:ENSG00000169683
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in colon (RPKM 3.3), bone marrow (RPKM 3.0) and 25 other tissues See more
Orthologs
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Genomic context

See LRRC45 in Genome Data Viewer
Location:
17q25.3
Exon count:
17
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (82023252..82031151)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79981181..79989027)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ASPSCR1 tether for SLC2A4, UBX domain containing Neighboring gene centromere protein X Neighboring gene Rac family small GTPase 3 Neighboring gene dicarbonyl and L-xylulose reductase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC20806

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
leucine-rich repeat-containing protein 45

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144999.4NP_659436.1  leucine-rich repeat-containing protein 45

    See identical proteins and their annotated locations for NP_659436.1

    Status: VALIDATED

    Source sequence(s)
    AC137723, BC014109, BI837975
    Consensus CDS
    CCDS11797.1
    UniProtKB/Swiss-Prot
    Q96CN5
    Related
    ENSP00000306760.3, ENST00000306688.8
    Conserved Domains (3) summary
    sd00033
    Location:6184
    LRR_RI; leucine-rich repeat [structural motif]
    cl25732
    Location:267634
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26161
    Location:34224
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    82023252..82031151
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_933932.2 RNA Sequence

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