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SLC16A13 solute carrier family 16 member 13 [ Homo sapiens (human) ]

Gene ID: 201232, updated on 22-Sep-2022

Summary

Official Symbol
SLC16A13provided by HGNC
Official Full Name
solute carrier family 16 member 13provided by HGNC
Primary source
HGNC:HGNC:31037
See related
Ensembl:ENSG00000174327 AllianceGenome:HGNC:31037
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCT13
Summary
Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in monocarboxylic acid transport. Located in Golgi apparatus and cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver (RPKM 11.1), kidney (RPKM 6.1) and 17 other tissues See more
Orthologs
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Genomic context

See SLC16A13 in Genome Data Viewer
Location:
17p13.1
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (7036015..7040117)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (6936666..6940776)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (6939334..6943436)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene mir-497-195 cluster host gene Neighboring gene microRNA 497 Neighboring gene BCL6B transcription repressor Neighboring gene uncharacterized LOC124903909 Neighboring gene solute carrier family 16 member 11 Neighboring gene C-type lectin domain containing 10A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies three novel loci for type 2 diabetes.
EBI GWAS Catalog
Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables monocarboxylic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in monocarboxylic acid transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
monocarboxylate transporter 13
Names
MCT 13
monocarboxylic acid transporter 13
solute carrier family 16 (monocarboxylic acid transporters), member 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201566.3NP_963860.1  monocarboxylate transporter 13

    See identical proteins and their annotated locations for NP_963860.1

    Status: VALIDATED

    Source sequence(s)
    AC040977, BC142618
    Consensus CDS
    CCDS11085.1
    UniProtKB/Swiss-Prot
    Q2VP92, Q7RTY0
    Related
    ENSP00000309751.6, ENST00000308027.7
    Conserved Domains (3) summary
    cd06174
    Location:14392
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:21357
    MFS_1; Major Facilitator Superfamily
    pfam11371
    Location:369419
    DUF3172; Protein of unknown function (DUF3172)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    7036015..7040117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    6936666..6940776
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)