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ARHGAP27 Rho GTPase activating protein 27 [ Homo sapiens (human) ]

Gene ID: 201176, updated on 1-Jun-2020

Summary

Official Symbol
ARHGAP27provided by HGNC
Official Full Name
Rho GTPase activating protein 27provided by HGNC
Primary source
HGNC:HGNC:31813
See related
Ensembl:ENSG00000159314 MIM:610591
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP905; SH3D20; SH3P20; CAMGAP1
Summary
This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may pay a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2013]
Expression
Ubiquitous expression in esophagus (RPKM 12.5), spleen (RPKM 12.5) and 23 other tissues See more
Orthologs

Genomic context

See ARHGAP27 in Genome Data Viewer
Location:
17q21.31
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (45393902..45432916, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (43471268..43510282, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371796 Neighboring gene Sharpr-MPRA regulatory region 455 Neighboring gene pleckstrin homology and RUN domain containing M1 Neighboring gene microRNA 4315-1 Neighboring gene uncharacterized LOC105369225 Neighboring gene leucine rich repeat containing 37 member A4, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35572, FLJ43547, FLJ76025, MGC78393, MGC120624

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
SH3 domain binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
positive regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
receptor-mediated endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
rho GTPase-activating protein 27
Names
CIN85-associated multi-domain-containing Rho GTPase-activating protein 1
SH3 domain containing 20
SH3 domain-containing protein 20
rho-type GTPase-activating protein 27

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282290.1NP_001269219.1  rho GTPase-activating protein 27 isoform d

    See identical proteins and their annotated locations for NP_001269219.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (d).
    Source sequence(s)
    AC003070, AC091132
    Consensus CDS
    CCDS74082.1
    UniProtKB/Swiss-Prot
    Q6ZUM4
    Related
    ENSP00000403323.1, ENST00000428638.5
    Conserved Domains (6) summary
    smart00456
    Location:417443
    WW; Domain with 2 conserved Trp (W) residues
    cd12069
    Location:1066
    SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27
    cd04403
    Location:695881
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:499613
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:499611
    PH; PH domain
    pfam00397
    Location:247278
    WW; WW domain
  2. NM_174919.3NP_777579.2  rho GTPase-activating protein 27 isoform c

    See identical proteins and their annotated locations for NP_777579.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) is a short variant at the 5' end of a much longer ARHGAP27 gene, and differs in the UTRs and CDS compared to variant 4. The encoded isoform (c) is shorter than isoform d.
    Source sequence(s)
    AF258593, BC067345
    Consensus CDS
    CCDS32670.1
    UniProtKB/Swiss-Prot
    Q6ZUM4
    Related
    ENSP00000290470.3, ENST00000290470.3
    Conserved Domains (1) summary
    cd12069
    Location:1066
    SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27
  3. NM_199282.3NP_954976.1  rho GTPase-activating protein 27 isoform a

    See identical proteins and their annotated locations for NP_954976.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is a short variant at the 3' end of a longer ARHGAP27 gene and differs in the 5' UTR and CDS compared to variant 4. The encoded isoform (a) is shorter than isoform d.
    Source sequence(s)
    AK125535, BC029634, BC101391, BX386761, CD675139
    Consensus CDS
    CCDS11498.1
    UniProtKB/Swiss-Prot
    Q6ZUM4
    UniProtKB/TrEMBL
    Q8N2Y9
    Related
    ENSP00000366121.2, ENST00000376922.6
    Conserved Domains (5) summary
    smart00456
    Location:76102
    WW; Domain with 2 conserved Trp (W) residues
    cd00201
    Location:5282
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:354540
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:158272
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:158270
    PH; PH domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    45393902..45432916 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524471.1XP_011522773.1  rho GTPase-activating protein 27 isoform X6

    See identical proteins and their annotated locations for XP_011522773.1

    Conserved Domains (6) summary
    smart00456
    Location:360386
    WW; Domain with 2 conserved Trp (W) residues
    cd12069
    Location:1066
    SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27
    cd04403
    Location:671857
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:442556
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:442554
    PH; PH domain
    pfam00397
    Location:247278
    WW; WW domain
  2. XM_006721747.2XP_006721810.1  rho GTPase-activating protein 27 isoform X5

    See identical proteins and their annotated locations for XP_006721810.1

    UniProtKB/TrEMBL
    E9PIR1
    Related
    ENSP00000433942.1, ENST00000532891.6
    Conserved Domains (6) summary
    smart00456
    Location:417443
    WW; Domain with 2 conserved Trp (W) residues
    cd12069
    Location:1066
    SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27
    cd04403
    Location:673859
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:477591
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:477589
    PH; PH domain
    pfam00397
    Location:247278
    WW; WW domain
  3. XM_011524469.1XP_011522771.1  rho GTPase-activating protein 27 isoform X2

    See identical proteins and their annotated locations for XP_011522771.1

    Conserved Domains (6) summary
    smart00456
    Location:417443
    WW; Domain with 2 conserved Trp (W) residues
    cd12069
    Location:1066
    SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27
    cd04403
    Location:706892
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:477591
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:477589
    PH; PH domain
    pfam00397
    Location:247278
    WW; WW domain
  4. XM_006721745.2XP_006721808.1  rho GTPase-activating protein 27 isoform X3

    See identical proteins and their annotated locations for XP_006721808.1

    UniProtKB/Swiss-Prot
    Q6ZUM4
    Conserved Domains (6) summary
    smart00456
    Location:417443
    WW; Domain with 2 conserved Trp (W) residues
    cd12069
    Location:1066
    SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27
    cd04403
    Location:695881
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:499613
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:499611
    PH; PH domain
    pfam00397
    Location:247278
    WW; WW domain
  5. XM_011524468.1XP_011522770.1  rho GTPase-activating protein 27 isoform X1

    See identical proteins and their annotated locations for XP_011522770.1

    Conserved Domains (6) summary
    smart00456
    Location:417443
    WW; Domain with 2 conserved Trp (W) residues
    cd12069
    Location:1066
    SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27
    cd04403
    Location:728914
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:499613
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:499611
    PH; PH domain
    pfam00397
    Location:247278
    WW; WW domain
  6. XM_011524470.2XP_011522772.1  rho GTPase-activating protein 27 isoform X4

    See identical proteins and their annotated locations for XP_011522772.1

    Conserved Domains (6) summary
    smart00456
    Location:417443
    WW; Domain with 2 conserved Trp (W) residues
    cd12069
    Location:1066
    SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27
    cd13233
    Location:499613
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:499611
    PH; PH domain
    pfam00397
    Location:247278
    WW; WW domain
    cl02570
    Location:728828
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
  7. XM_017024311.1XP_016879800.1  rho GTPase-activating protein 27 isoform X1

    Conserved Domains (6) summary
    smart00456
    Location:417443
    WW; Domain with 2 conserved Trp (W) residues
    cd12069
    Location:1066
    SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27
    cd04403
    Location:728914
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:499613
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:499611
    PH; PH domain
    pfam00397
    Location:247278
    WW; WW domain
  8. XM_011524474.1XP_011522776.1  rho GTPase-activating protein 27 isoform X13

    See identical proteins and their annotated locations for XP_011522776.1

    Conserved Domains (5) summary
    smart00456
    Location:76102
    WW; Domain with 2 conserved Trp (W) residues
    cd00201
    Location:5282
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:387573
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:158272
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:158270
    PH; PH domain
  9. XM_005257128.3XP_005257185.1  rho GTPase-activating protein 27 isoform X9

    See identical proteins and their annotated locations for XP_005257185.1

    UniProtKB/TrEMBL
    E9PNT2
    Related
    ENSP00000432762.1, ENST00000532038.5
    Conserved Domains (5) summary
    smart00456
    Location:217243
    WW; Domain with 2 conserved Trp (W) residues
    cd04403
    Location:473659
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:277391
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:277389
    PH; PH domain
    pfam00397
    Location:4778
    WW; WW domain
  10. XM_011524472.2XP_011522774.1  rho GTPase-activating protein 27 isoform X7

    See identical proteins and their annotated locations for XP_011522774.1

    Conserved Domains (5) summary
    smart00456
    Location:217243
    WW; Domain with 2 conserved Trp (W) residues
    cd04403
    Location:528714
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:299413
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:299411
    PH; PH domain
    pfam00397
    Location:4778
    WW; WW domain
  11. XM_017024312.1XP_016879801.1  rho GTPase-activating protein 27 isoform X8

  12. XM_017024313.1XP_016879802.1  rho GTPase-activating protein 27 isoform X10

  13. XM_006721750.4XP_006721813.1  rho GTPase-activating protein 27 isoform X11

    See identical proteins and their annotated locations for XP_006721813.1

    Conserved Domains (4) summary
    cd12069
    Location:1066
    SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27
    cd13233
    Location:499613
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:499611
    PH; PH domain
    pfam00397
    Location:247278
    WW; WW domain
  14. XM_011524473.2XP_011522775.1  rho GTPase-activating protein 27 isoform X12

    See identical proteins and their annotated locations for XP_011522775.1

    Conserved Domains (3) summary
    cd12069
    Location:1066
    SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27
    pfam00397
    Location:247278
    WW; WW domain
    cl17171
    Location:499582
    PH-like; Pleckstrin homology-like domain

RNA

  1. XR_002957982.1 RNA Sequence

  2. XR_934416.2 RNA Sequence

  3. XR_934417.3 RNA Sequence

  4. XR_001752447.1 RNA Sequence

  5. XR_001752448.1 RNA Sequence

  6. XR_429876.3 RNA Sequence

  7. XR_429873.3 RNA Sequence

  8. XR_001752446.1 RNA Sequence

  9. XR_429875.3 RNA Sequence

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_167251.2 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    84423..123414 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_187663.1 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    84405..123421 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001159330.1: Suppressed sequence

    Description
    NM_001159330.1: This RefSeq was temporarily suppressed because currently there is insufficient support for the transcript and the protein.
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