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PLD6 phospholipase D family member 6 [ Homo sapiens (human) ]

Gene ID: 201164, updated on 2-Mar-2021

Summary

Official Symbol
PLD6provided by HGNC
Official Full Name
phospholipase D family member 6provided by HGNC
Primary source
HGNC:HGNC:30447
See related
Ensembl:ENSG00000179598 MIM:614960
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZUC
Expression
Broad expression in testis (RPKM 12.6), prostate (RPKM 3.8) and 25 other tissues See more
Orthologs
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Genomic context

See PLD6 in Genome Data Viewer
Location:
17p11.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (17200990..17206905, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (17104309..17109647, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene myosin phosphatase Rho interacting protein Neighboring gene RNA, U6 small nuclear 767, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 775, pseudogene Neighboring gene folliculin Neighboring gene actin gamma 1 pseudogene 24

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cardiolipin hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
DNA methylation involved in gamete generation ISS
Inferred from Sequence or Structural Similarity
more info
 
P granule organization ISS
Inferred from Sequence or Structural Similarity
more info
 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
meiotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrial fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleic acid phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
 
phosphatidic acid biosynthetic process TAS
Traceable Author Statement
more info
 
piRNA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
piRNA metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of mitochondrial fusion IDA
Inferred from Direct Assay
more info
PubMed 
spermatid development ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial outer membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
mitochondrial cardiolipin hydrolase
Names
PLD 6
choline phosphatase 6
mitoPLD
mitochondrial phospholipase
phosphatidylcholine-hydrolyzing phospholipase D6
phospholipase D6
protein zucchini homolog
NP_849158.2
XP_016879799.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178836.4NP_849158.2  mitochondrial cardiolipin hydrolase

    See identical proteins and their annotated locations for NP_849158.2

    Status: VALIDATED

    Source sequence(s)
    AC055811, AK090899, BC031263, DC326979
    Consensus CDS
    CCDS11182.1
    UniProtKB/Swiss-Prot
    Q8N2A8
    Related
    ENSP00000317177.3, ENST00000321560.4
    Conserved Domains (2) summary
    cd09171
    Location:95206
    PLDc_vPLD6_like; Catalytic domain of vertebrate phospholipase D6 and similar proteins
    pfam13091
    Location:95206
    PLDc_2; PLD-like domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    17200990..17206905 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024310.2XP_016879799.2  mitochondrial cardiolipin hydrolase isoform X1

    Conserved Domains (1) summary
    cl15239
    Location:139185
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins
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