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CENPV centromere protein V [ Homo sapiens (human) ]

Gene ID: 201161, updated on 5-Sep-2021

Summary

Official Symbol
CENPVprovided by HGNC
Official Full Name
centromere protein Vprovided by HGNC
Primary source
HGNC:HGNC:29920
See related
Ensembl:ENSG00000166582 MIM:608139
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p30; PRR6; CENP-V; 3110013H01Rik
Expression
Broad expression in small intestine (RPKM 17.0), duodenum (RPKM 16.5) and 25 other tissues See more
Orthologs
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Genomic context

See CENPV in Genome Data Viewer
Location:
17p11.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (16342537..16353469, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (16245851..16256783, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol glycan anchor biosynthesis class L Neighboring gene Sharpr-MPRA regulatory region 12459 Neighboring gene microRNA 1288 Neighboring gene ubiquitin B Neighboring gene ferritin light chain pseudogene 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbon-sulfur lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within ameboidal-type cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in centromere complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pericentric heterochromatin assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in pericentric heterochromatin assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of chromosome organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of chromosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in spindle midzone IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
centromere protein V
Names
nuclear protein p30
proline rich 6
proline-rich protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181716.3NP_859067.2  centromere protein V

    See identical proteins and their annotated locations for NP_859067.2

    Status: VALIDATED

    Source sequence(s)
    AF514992, BQ052702, BU618545
    Consensus CDS
    CCDS32575.1
    UniProtKB/Swiss-Prot
    Q7Z7K6
    Related
    ENSP00000299736.4, ENST00000299736.5
    Conserved Domains (1) summary
    COG3791
    Location:144240
    COG3791; Uncharacterized conserved protein [Function unknown]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    16342537..16353469 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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