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DHRS7C dehydrogenase/reductase 7C [ Homo sapiens (human) ]

Gene ID: 201140, updated on 5-Aug-2022

Summary

Official Symbol
DHRS7Cprovided by HGNC
Official Full Name
dehydrogenase/reductase 7Cprovided by HGNC
Primary source
HGNC:HGNC:32423
See related
Ensembl:ENSG00000184544 MIM:616161; AllianceGenome:HGNC:32423
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SDR32C2
Summary
Predicted to enable NAD-retinol dehydrogenase activity. Predicted to be involved in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum. Predicted to be located in extracellular region and longitudinal sarcoplasmic reticulum. Predicted to be active in sarcoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward heart (RPKM 31.7) See more
Orthologs
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Genomic context

See DHRS7C in Genome Data Viewer
Location:
17p13.1
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (9771438..9791592, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (9679162..9699310, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (9674755..9694909, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 52 Neighboring gene uncharacterized LOC124903924 Neighboring gene uncharacterized LOC107985011 Neighboring gene ubiquitin specific peptidase 43 Neighboring gene DHRS7C intron CAGE-defined high expression enhancer Neighboring gene uncharacterized LOC124903925 Neighboring gene GSG1 like 2 Neighboring gene glucagon like peptide 2 receptor Neighboring gene nucleophosmin 1 pseudogene 45

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: GSG1L2

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NAD-retinol dehydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular calcium ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in glucose import ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in longitudinal sarcoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in sarcoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
dehydrogenase/reductase SDR family member 7C
Names
dehydrogenase/reductase (SDR family) member 7C
sarcoplasmic reticulum protein of 35 kDa
short-chain dehydrogenase/reductase family 32C member 2
NP_001099041.1
NP_001207422.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105571.3NP_001099041.1  dehydrogenase/reductase SDR family member 7C isoform 2 precursor

    See identical proteins and their annotated locations for NP_001099041.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC027045, AI091419, AI168267, BC147024
    Consensus CDS
    CCDS58517.1
    UniProtKB/Swiss-Prot
    A6NNS2
    Related
    ENSP00000459579.1, ENST00000571134.2
    Conserved Domains (1) summary
    cd05332
    Location:35296
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
  2. NM_001220493.2NP_001207422.1  dehydrogenase/reductase SDR family member 7C isoform 1 precursor

    See identical proteins and their annotated locations for NP_001207422.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC027045, AI091419, AI168267, BC171909
    Consensus CDS
    CCDS56020.1
    UniProtKB/Swiss-Prot
    A6NNS2, B9EJH3
    Related
    ENSP00000327975.4, ENST00000330255.9
    Conserved Domains (1) summary
    cd05332
    Location:35297
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    9771438..9791592 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    9679162..9699310 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)