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MARK2 microtubule affinity regulating kinase 2 [ Homo sapiens (human) ]

Gene ID: 2011, updated on 10-Jun-2018
Official Symbol
MARK2provided by HGNC
Official Full Name
microtubule affinity regulating kinase 2provided by HGNC
Primary source
HGNC:HGNC:3332
See related
Ensembl:ENSG00000072518 MIM:600526; Vega:OTTHUMG00000160504
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EMK1; EMK-1; PAR-1; Par1b; Par-1b
Summary
This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]
Expression
Ubiquitous expression in esophagus (RPKM 11.9), colon (RPKM 10.6) and 25 other tissues See more
Orthologs
See MARK2 in Genome Data Viewer
Location:
11q13.1
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (63838928..63911020)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63606400..63678492)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene spindlin interactor and repressor of chromatin binding Neighboring gene ATP synthase membrane subunit g pseudogene 1 Neighboring gene RNA, U6 small nuclear 1306, pseudogene Neighboring gene transfer RNA-Arg (CCT) 9-1 Neighboring gene REST corepressor 2 Neighboring gene N(alpha)-acetyltransferase 40, NatD catalytic subunit

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study of blood pressure response to methylphenidate treatment of attention-deficit/hyperactivity disorder.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC99619

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding HDA PubMed 
cadherin binding HDA PubMed 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activator activity TAS
Traceable Author Statement
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein serine/threonine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
tau protein binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
tau-protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tau-protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
tau-protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
activation of protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
autophagy of mitochondrion NAS
Non-traceable Author Statement
more info
PubMed 
axon development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
establishment of cell polarity IDA
Inferred from Direct Assay
more info
PubMed 
establishment of cell polarity TAS
Traceable Author Statement
more info
PubMed 
establishment or maintenance of cell polarity regulating cell shape ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
establishment or maintenance of epithelial cell apical/basal polarity IDA
Inferred from Direct Assay
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion localization NAS
Non-traceable Author Statement
more info
PubMed 
neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
peptidyl-threonine phosphorylation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
regulation of axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of microtubule cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
actin filament IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
lateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule bundle IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion NAS
Non-traceable Author Statement
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
serine/threonine-protein kinase MARK2
Names
ELKL motif kinase 1
MAP/microtubule affinity-regulating kinase 2
PAR1 homolog b
Ser/Thr protein kinase PAR-1B
serine/threonine protein kinase EMK
testicular tissue protein Li 117
NP_001034558.2
NP_001156768.1
NP_001156769.1
NP_004945.4
NP_059672.2
XP_011543091.1
XP_011543092.1
XP_011543093.1
XP_011543094.1
XP_011543095.1
XP_011543096.1
XP_011543097.1
XP_011543098.1
XP_011543099.1
XP_011543100.1
XP_016872799.1
XP_016872800.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029771.1 RefSeqGene

    Range
    5001..77093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001039469.2NP_001034558.2  serine/threonine-protein kinase MARK2 isoform d

    See identical proteins and their annotated locations for NP_001034558.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (d).
    Source sequence(s)
    AB188493, AK225766, AP003780, BC008771, BM719402
    Consensus CDS
    CCDS53649.1
    UniProtKB/Swiss-Prot
    Q7KZI7
    Related
    ENSP00000385751.2, ENST00000402010.6
    Conserved Domains (3) summary
    cd12201
    Location:689787
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    cd14406
    Location:322363
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:52304
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  2. NM_001163296.1NP_001156768.1  serine/threonine-protein kinase MARK2 isoform e

    See identical proteins and their annotated locations for NP_001156768.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two alternate in-frame exons in the 3' coding region, compared to variant 4. The resulting isoform (e) lacks two internal segments, compared to isoform d.
    Source sequence(s)
    AB188493, AK225766, AP003780, BM719402
    Consensus CDS
    CCDS53650.1
    UniProtKB/Swiss-Prot
    Q7KZI7
    UniProtKB/TrEMBL
    A0A140VJP1
    Related
    ENSP00000355091.5, OTTHUMP00000236749, ENST00000361128.9, OTTHUMT00000396087
    Conserved Domains (3) summary
    cd12201
    Location:620718
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    cd14406
    Location:322363
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:52304
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  3. NM_001163297.1NP_001156769.1  serine/threonine-protein kinase MARK2 isoform f

    See identical proteins and their annotated locations for NP_001156769.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks three alternate in-frame exons and uses an alternate in-frame splice site, compared to variant 4. The resulting isoform (f) lacks two internal segments and 1 internal residue, compared to isoform d.
    Source sequence(s)
    AB188493, AK225766, AP003780, BM719402
    Consensus CDS
    CCDS53651.1
    UniProtKB/Swiss-Prot
    Q7KZI7
    Related
    ENSP00000294247.9, OTTHUMP00000236750, ENST00000350490.11, OTTHUMT00000396088
    Conserved Domains (3) summary
    cd12201
    Location:610708
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    cd14406
    Location:322363
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:52304
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  4. NM_004954.4NP_004945.4  serine/threonine-protein kinase MARK2 isoform c

    See identical proteins and their annotated locations for NP_004945.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 3' coding region and uses an alternate in-frame splice site in the central coding region, compared to variant 4. The resulting isoform (c) lacks two internal segments and 1 internal residue, compared to isoform d.
    Source sequence(s)
    AB188493, AK225766, AP003780, BC084540, BM719402
    Consensus CDS
    CCDS8051.2
    UniProtKB/Swiss-Prot
    Q7KZI7
    Related
    ENSP00000425765.1, OTTHUMP00000218338, ENST00000508192.5, OTTHUMT00000360860
    Conserved Domains (3) summary
    cd12201
    Location:625723
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    cd14406
    Location:322363
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:52304
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  5. NM_017490.3NP_059672.2  serine/threonine-protein kinase MARK2 isoform a

    See identical proteins and their annotated locations for NP_059672.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, lacks an in-frame exon, and uses an alternate in-frame splice site, compared to variant 4. The resulting isoform (a) has a shorter N-terminus and lacks an internal segment and 1 internal residue, compared to isoform d.
    Source sequence(s)
    AK290339, AP003780, BM719402, BT007342, DA855402
    Consensus CDS
    CCDS41665.1
    UniProtKB/Swiss-Prot
    Q7KZI7
    UniProtKB/TrEMBL
    A8K2S4
    Related
    ENSP00000423974.2, OTTHUMP00000218340, ENST00000509502.6, OTTHUMT00000360862
    Conserved Domains (3) summary
    cd12201
    Location:646744
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    cd14406
    Location:289330
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:19271
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    63838928..63911020
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017310.1XP_016872799.1  serine/threonine-protein kinase MARK2 isoform X6

    Related
    ENSP00000423452.3, OTTHUMP00000218339, ENST00000502399.7, OTTHUMT00000360861
  2. XM_011544789.1XP_011543091.1  serine/threonine-protein kinase MARK2 isoform X1

    Conserved Domains (4) summary
    cd12201
    Location:709807
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    smart00220
    Location:73324
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14406
    Location:342383
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:72324
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  3. XM_011544792.1XP_011543094.1  serine/threonine-protein kinase MARK2 isoform X4

    Conserved Domains (4) summary
    cd12201
    Location:694792
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    smart00220
    Location:73324
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14406
    Location:342383
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:72324
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  4. XM_011544790.1XP_011543092.1  serine/threonine-protein kinase MARK2 isoform X2

    Conserved Domains (4) summary
    cd12201
    Location:700798
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    smart00220
    Location:73324
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14406
    Location:342383
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:72324
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  5. XM_011544793.1XP_011543095.1  serine/threonine-protein kinase MARK2 isoform X5

    Conserved Domains (4) summary
    cd12201
    Location:685783
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    smart00220
    Location:73324
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14406
    Location:342383
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:72324
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  6. XM_011544797.1XP_011543099.1  serine/threonine-protein kinase MARK2 isoform X10

    Conserved Domains (4) summary
    cd12201
    Location:640738
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    smart00220
    Location:73324
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14406
    Location:342383
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:72324
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  7. XM_011544795.1XP_011543097.1  serine/threonine-protein kinase MARK2 isoform X8

    Conserved Domains (4) summary
    cd12201
    Location:646744
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    smart00220
    Location:73324
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14406
    Location:342383
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:72324
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  8. XM_011544791.1XP_011543093.1  serine/threonine-protein kinase MARK2 isoform X3

    Conserved Domains (4) summary
    cd12201
    Location:699797
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    smart00220
    Location:73324
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14406
    Location:342383
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:72324
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  9. XM_011544794.1XP_011543096.1  serine/threonine-protein kinase MARK2 isoform X7

    Conserved Domains (4) summary
    cd12201
    Location:654752
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    smart00220
    Location:73324
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14406
    Location:342383
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:72324
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  10. XM_017017311.1XP_016872800.1  serine/threonine-protein kinase MARK2 isoform X11

  11. XM_011544796.1XP_011543098.1  serine/threonine-protein kinase MARK2 isoform X9

    Conserved Domains (4) summary
    cd12201
    Location:645743
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    smart00220
    Location:73324
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14406
    Location:342383
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:72324
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  12. XM_011544798.1XP_011543100.1  serine/threonine-protein kinase MARK2 isoform X12

    Conserved Domains (4) summary
    cd12201
    Location:630728
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    smart00220
    Location:73324
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14406
    Location:342383
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:72324
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

RNA

  1. XR_949802.2 RNA Sequence

  2. XR_002957128.1 RNA Sequence

  3. XR_949801.2 RNA Sequence

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