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MARK2 microtubule affinity regulating kinase 2 [ Homo sapiens (human) ]

Gene ID: 2011, updated on 6-Oct-2024

Summary

Official Symbol
MARK2provided by HGNC
Official Full Name
microtubule affinity regulating kinase 2provided by HGNC
Primary source
HGNC:HGNC:3332
See related
Ensembl:ENSG00000072518 MIM:600526; AllianceGenome:HGNC:3332
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EMK1; EMK-1; PAR-1; Par1b; Par-1b
Summary
This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]
Expression
Ubiquitous expression in esophagus (RPKM 11.9), colon (RPKM 10.6) and 25 other tissues See more
Orthologs
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Genomic context

See MARK2 in Genome Data Viewer
Location:
11q13.1
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (63839110..63911020)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (63828449..63900374)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63606582..63678492)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3446 Neighboring gene spindlin interactor and repressor of chromatin binding Neighboring gene ReSE screen-validated silencer GRCh37_chr11:63598793-63599010 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63599819-63600638 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63605268-63606256 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4875 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3447 Neighboring gene ATP synthase membrane subunit g pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4876 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4877 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:63642729-63643230 Neighboring gene RNA, U6 small nuclear 1306, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4878 Neighboring gene tRNA-Arg (anticodon CCT) 9-1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63670286-63671098 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63674933-63675606 Neighboring gene Sharpr-MPRA regulatory region 844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63682139-63683091 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:63683713-63684376 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3448 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3449 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3450 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63687688-63688350 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63688351-63689011 Neighboring gene REST corepressor 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63705477-63705977 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3451 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4879 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:63706395-63706580 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63712515-63713444 Neighboring gene N-alpha-acetyltransferase 40, NatD catalytic subunit

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of blood pressure response to methylphenidate treatment of attention-deficit/hyperactivity disorder.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC99619

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding HDA PubMed 
enables cadherin binding HDA PubMed 
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activator activity TAS
Traceable Author Statement
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables protein serine/threonine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables tau protein binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables tau protein binding NAS
Non-traceable Author Statement
more info
PubMed 
enables tau-protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables tau-protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables tau-protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables tau-protein kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in activation of protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
involved_in autophagy of mitochondrion NAS
Non-traceable Author Statement
more info
PubMed 
involved_in axon development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in establishment of cell polarity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in establishment of cell polarity TAS
Traceable Author Statement
more info
PubMed 
involved_in establishment or maintenance of cell polarity regulating cell shape ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in establishment or maintenance of epithelial cell apical/basal polarity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitochondrion localization NAS
Non-traceable Author Statement
more info
PubMed 
involved_in neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in peptidyl-threonine phosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in regulation of microtubule cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in actin filament IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in lateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in microtubule bundle IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase MARK2
Names
ELKL motif kinase 1
MAP/microtubule affinity-regulating kinase 2
PAR1 homolog b
Ser/Thr protein kinase PAR-1B
serine/threonine protein kinase EMK
testicular tissue protein Li 117
NP_001034558.2
NP_001156768.1
NP_001156769.1
NP_004945.4
NP_059672.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029771.1 RefSeqGene

    Range
    5183..77093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001039469.3NP_001034558.2  serine/threonine-protein kinase MARK2 isoform d

    See identical proteins and their annotated locations for NP_001034558.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (d).
    Source sequence(s)
    AB188493, AK225766, AP003780, BC008771, BM719402
    Consensus CDS
    CCDS53649.1
    UniProtKB/Swiss-Prot
    Q15449, Q15524, Q5XGA3, Q68A18, Q7KZI7, Q96HB3, Q96RG0
    UniProtKB/TrEMBL
    A8K2S4
    Related
    ENSP00000385751.2, ENST00000402010.8
    Conserved Domains (3) summary
    cd12201
    Location:689787
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    cd14406
    Location:322363
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:52304
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  2. NM_001163296.2NP_001156768.1  serine/threonine-protein kinase MARK2 isoform e

    See identical proteins and their annotated locations for NP_001156768.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two alternate in-frame exons in the 3' coding region, compared to variant 4. The resulting isoform (e) lacks two internal segments, compared to isoform d.
    Source sequence(s)
    AB188493, AK225766, AP003780, BM719402
    Consensus CDS
    CCDS53650.1
    UniProtKB/TrEMBL
    A0A0A0MRU9, A0A140VJP1
    Related
    ENSP00000355091.5, ENST00000361128.9
    Conserved Domains (3) summary
    cd12201
    Location:620718
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    cd14406
    Location:322363
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:52304
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  3. NM_001163297.2NP_001156769.1  serine/threonine-protein kinase MARK2 isoform f

    See identical proteins and their annotated locations for NP_001156769.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks three alternate in-frame exons and uses an alternate in-frame splice site, compared to variant 4. The resulting isoform (f) lacks two internal segments and 1 internal residue, compared to isoform d.
    Source sequence(s)
    AK225766, AP003780, BM719402
    Consensus CDS
    CCDS53651.1
    UniProtKB/TrEMBL
    A0A0A0MRU9
    Related
    ENSP00000294247.9, ENST00000350490.11
    Conserved Domains (3) summary
    cd12201
    Location:610708
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    cd14406
    Location:322363
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:52304
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  4. NM_004954.5NP_004945.4  serine/threonine-protein kinase MARK2 isoform c

    See identical proteins and their annotated locations for NP_004945.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 3' coding region and uses an alternate in-frame splice site in the central coding region, compared to variant 4. The resulting isoform (c) lacks two internal segments and 1 internal residue, compared to isoform d.
    Source sequence(s)
    AK225766, AP003780, BC084540, BM719402
    Consensus CDS
    CCDS8051.2
    UniProtKB/TrEMBL
    A0A0A0MRU9
    Related
    ENSP00000425765.1, ENST00000508192.5
    Conserved Domains (3) summary
    cd12201
    Location:625723
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    cd14406
    Location:322363
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:52304
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  5. NM_017490.4NP_059672.2  serine/threonine-protein kinase MARK2 isoform a

    See identical proteins and their annotated locations for NP_059672.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, lacks an in-frame exon, and uses an alternate in-frame splice site, compared to variant 4. The resulting isoform (a) has a shorter N-terminus and lacks an internal segment and 1 internal residue, compared to isoform d.
    Source sequence(s)
    AK290339, AP003780, BM719402, BT007342, DA855402
    Consensus CDS
    CCDS41665.1
    UniProtKB/TrEMBL
    A8K2S4
    Related
    ENSP00000423974.2, ENST00000509502.6
    Conserved Domains (3) summary
    cd12201
    Location:646744
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    cd14406
    Location:289330
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:19271
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    63839110..63911020
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    63828449..63900374
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)